Sentences with phrase «tumour cells from»

The team is currently working on genome sequencing of individual circulating tumour cells from patients at the Vancouver Prostate Centre.

By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing.

One method is to remove some tumour cells from the patient at the time of surgery, insert a gene for an immune - stimulating protein into them, and return them to the body.

Geneva, Switzerland, 26 March 2014 — A new era of lung cancer therapy is close to dawning, using drugs that can prevent tumour cells from evading the immune system, experts have said at the 4th European Lung Cancer Congress.

Initially, the Geneva researchers observed the vascularisation processes of human tumour cells from different cell lines.

A new era of lung cancer therapy is close to dawning, using drugs that can prevent tumour cells from evading the immune system, experts have said at the 4th European Lung Cancer Congress.

To carry out the study, the team has analysed how different carbohydrates act on the surface of silver nanoparticles (Ag - NP) of around 50 nanometres, which have been introduced into cultures of liver cells and tumour cells from the nervous system of mice.

For the first time ever, we could make a really comprehensive comparison of individual normal and tumour cells from the exact same type of tissue, taken at the same time, from the same person, and see how the cancer had developed.»

Anne Goriely of the University of Oxford and her colleagues took tumour cells from men with benign testicular tumours and looked for specific mutations in the FGFR3 and HRAS genes.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

Not exact matches

Injections of killed stem cells, designed to help the immune system recognise cancers, have been found to protect mice from developing tumours

Because such cells are derived from adult cells, not pluripotent cells — which have the potential to form a kind of tumour called a teratoma — they might be safer than iPS cells.

They found 60 per cent fewer blood vessels surrounding tumour - like tissue grown from Down's stem cells than those from other volunteers.

«Myeloid - derived suppressor cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the tumour to hide it from cytotoxic lymphocytes that kill tumour cells.

That drug stops the tumour from reprogramming immune cells.

These were released into tumour cells that had been taken from glioblastoma patients and grown in the lab.

He suggests, instead, that the team take T cells from the site of the tumour, because they would already be specialized for attacking cancer.

The real test will be to inject these cells into mice and see if they form teratomas — tumours containing tissue or structures derived from all three germ layers.

Like a cruel form of mind control, some cancerous tumours can reprogram some immune cells to «block» other immune cells from attacking, leaving the tumour free to grow.

Devil Facial Tumour Disease (DFTD) is a rare contagious facial tumour, which emerged from a neural (Schwann) cell in a single Tasmanian devil more than 18 yearTumour Disease (DFTD) is a rare contagious facial tumour, which emerged from a neural (Schwann) cell in a single Tasmanian devil more than 18 yeartumour, which emerged from a neural (Schwann) cell in a single Tasmanian devil more than 18 years ago.

High levels of the protein were also found in cultures of metastatic cells from tumours of the colon, breast, head and neck.

A DEVICE that filters cancer cells from human blood using sound could help to identify tumour cells that have spread.

We are looking for the proteins that make the tumour cells different to the host devils that they infect and then use these «tumour specific» proteins to design a vaccine that will save the devil from extinction.

The researchers hope that ultimately human trials will prove the efficacy of the OH14 compound in sensitising tumour cells and cancer stem cells to existing drug - based therapies thus disabling tumours from seeding new growth after treatment.

But studies from recent years suggest that tumours harbour drug - resistant cells long before they encounter therapy.

«In most cases we think the body's growth control mechanisms eventually stop the cells from proliferating further, but in occasional cases where additional mutations occur in the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the work.

This is important as one of the reasons tumour cells are so pernicious is that they are able to hide from the body's immune system, by hijacking macrophages.

Cell lines from human tumours did exist, but were considered unsafe: what if cancerous cells were transferred along with the vaccine?

Ironically, TRAIL normally delivers a signal for cells to die, but the Trinity scientists found that this molecule can also send a wound - healing message from tumour cells.

These cells pick up antigens from tumour cells and «introduce» them to T cells in the lymph nodes, spurring them into action against the tumour.

«Although relatively rare, childhood germ cell tumours need to be diagnosed accurately and followed up carefully to give us the best chances of treating them,» says Professor Nick Coleman from the Department of Pathology, University of Cambridge.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

Growing mini tumours in the lab from a patient's own cells could help doctors discover the best way to treat each person, homing in on the right drugs to use

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

Dr Sophie Roerink, joint first author from the Wellcome Sanger Institute, said: «We found mutational processes in these cancer cells that are just not seen in normal cells, leading to a huge increase in mutation rate for tumours compared with normal cells.

«Brain metastases are a secondary brain tumour, which means they are caused by cancer cells that escape from primary tumours like lung, breast or melanoma, and travel to the brain,» said Mohini Singh, the study's primary author and a PhD candidate in biochemistry at the Michael G. DeGroote School of Medicine at McMaster.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

The team worked on tissue from three patients with colorectal cancer, taking normal bowel stem cells and cells from four different areas of the tumours.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

Samples of tumours from bowel cancer patients given different doses of resveratrol showed that even lower doses can get into cancer cells and potentially affect processes involved in tumour growth.

To do this, they switched from using dead tumour cell samples to patient - derived tumour cell lines, in which fresh samples of a person's tumour are grafted onto mice and grown to the required volumes.

Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Goethe University Frankfurt have now shown that tumour cells kill specific cells in the vascular wall.

Such secondary tumours are formed when individual cells break away from the main tumour and travel through the bloodstream to distant areas of the body.

Researchers from the University of Portsmouth's Brain Tumour Research Centre of Excellence have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the brain.

In lab experiments, the research team used cell lines derived from 40 patient tumour samples to identify that CD151 contributes to the survival of cells of high - grade serous ovarian cancer origin.

In collaboration with Dr Gabriele Bonatz from the Augusta clinics in Bochum (Brustzentrum), Hatt's team confirmed the existence of TRPV1 in tumour cells in nine different samples from patients suffering from breast cancer.

While it is present on a number of different types of cells in the body, it is expressed at higher levels on metastatic tumour cells, including those which have spread from the lung.

When cancer cells from eg breast or lung tumours invade the bones through metastasis, the bone tissue is degraded.

Therefore, researchers from the CNIO's Experimental Oncology Group have focused their work on identifying a stromal cell population that fosters tumour growth, to later discover why they have this capacity and reverse it.