The researchers, working with cell cultures, first observed how individual
tumour cells kill specific cells in the vascular wall, called endothelial cells.
Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Goethe University Frankfurt have now shown that
tumour cells kill specific cells in the vascular wall.
This allows for potent
tumour cell killing, and an overall decreased metastatic burden.
Not exact matches
Injections of
killed stem
cells, designed to help the immune system recognise cancers, have been found to protect mice from developing
tumours
That now appears to be because they prompt the growth of the very
tumour cells they are meant to
kill.
TO
KILL a
tumour, go after its neighbours: it seems to be the
tumour - free tissue surrounding colon
tumours that fosters the cancer's most pernicious
cells.
«Myeloid - derived suppressor
cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the
tumour to hide it from cytotoxic lymphocytes that
kill tumour cells.
A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to
kill tumour cells, has been successfully tested by scientists.
«Pancreatic cancer is extremely hard to treat by chemotherapy, so this finding is important because vitamin A targets the non-cancerous tissue and makes the existing chemotherapy more effective,
killing the cancer
cells and shrinking
tumours.
«We could get some shrinkage of the
tumours with other types of treatment we tried before, but we never got a complete
cell kill,» he says.
Most researchers assumed that this is because a few rogue cancer
cells find ways to circumvent the drugs before the whole
tumour has been
killed off.
Saurabh Saha of BioMed Valley Discoveries in Kansas City, Missouri, and his colleagues wondered whether they could use the bacteria to selectively
kill mammalian
cells within cancerous
tumours, which often have a poor blood supply and therefore low oxygen levels.
The new device will allow for more accurate medical procedures that involve the use of ultrasound to
kill tumours, loosen blood clots and deliver drugs into targeted
cells.
Moving forward, the team is looking into ways to assess the feasibility of enhancing RUNX
tumour suppression or inhibiting RUNX mitotic function to
kill rapidly proliferating cancer
cells,» said Prof Ito.
After injecting them into the bloodstream, we are able to gather them around the
tumour using magnets and ensure that they don't
kill the healthy
cells,» explains Asst Prof Xu, who has been working on cancer diagnosis and drug delivery systems since 2004.
When they loaded sperm
cells with doxorubicin, a common chemo agent, and released them in a dish containing mini cervical cancer
tumours, the sperm swam towards the
tumours,
killing 87 per cent of their
cells within three days.
For cancer, he hopes to adopt a similar approach in which the transplanted nodes will contain T
cells trained to hunt down the antigens produced by
tumour cells and
kill them off.
Studies have shown that lymphocytes isolated from a patient's
tumour are often specifically programmed to
kill that patient's cancer
cells.
My research is working towards developing ways to kick - start this metabolic engine in patients» Natural Killer
cells in order to restore their capacity to
kill tumours.
They can detect and directly
kill tumour cells.
The
tumour killing functions of Natural Killer
cells require energy and to meet this demand NK
cells take on more fuel, which they burn within a metabolic engine to drive energy production.
«The cytotoxic chemotherapy can first
kill some cancer
cells and enhance the sensitivity of the
tumour toward ICB therapy, which then stimulates the effectiveness of the ICB therapy,» said co-author Gianpietro Dotti, PhD, professor of microbiology and immunology at the UNC School of Medicine and member of the UNC Lineberger Comprehensive Cancer Center.
These drugs can be targeted to interfere with signalling within the
tumour microenvironment or activate other processes which will
kill the cancer
cells.
As seen with pseudo-coloured scanning electron microscopy, two
cell -
killing T -
cells (red) attack a squamous mouth cancer
cell (white) after a patient received a vaccine containing antigens identified on the
tumour.
We target
tumours by exploring how the proteins found on the cancer
cell surface can be utilised to inhibit growth or
kill tumours.
We develop antibodies that may help us detect cancer
cells through highly sensitive medical imaging technologies, as well as antibodies that directly trigger
cell -
killing mechanisms in the
tumour.
T -
cells can also recognize and
kill tumour cells, but there aren't enough of them normally to carry out the task.
Chemotherapy uses systemic medications that
kill all fast - growing
cells in the dog's body, including
cells in dog
tumours.