Not exact matches
Researchers at the University of Gothenburg are focusing on how HAMLET can be
taken up into
tumour cells.
These were released into
tumour cells that had been
taken from glioblastoma patients and grown in the lab.
He suggests, instead, that the team
take T
cells from the site of the
tumour, because they would already be specialized for attacking cancer.
Anne Goriely of the University of Oxford and her colleagues
took tumour cells from men with benign testicular
tumours and looked for specific mutations in the FGFR3 and HRAS genes.
«
Tumour cells often
take advantage of existing mechanisms, such as the one we have described, to cause havoc.
But at the time, they thought it might
take years to pinpoint the precise position of the gene, sequence it, and understand how it causes mutations to accumulate in
tumour cells (This Week, 15 May).
For the first time ever, we could make a really comprehensive comparison of individual normal and
tumour cells from the exact same type of tissue,
taken at the same time, from the same person, and see how the cancer had developed.»
The team worked on tissue from three patients with colorectal cancer,
taking normal bowel stem
cells and
cells from four different areas of the
tumours.
First, the researchers inhibited the
tumour cell mitochondria, by restricting the cancer
cells only to glucose as a fuel source; then, they
took away their glucose, effectively starving the cancer
cells to death.
The
tumour killing functions of Natural Killer
cells require energy and to meet this demand NK
cells take on more fuel, which they burn within a metabolic engine to drive energy production.