Sentences with phrase «tumour cells with»

Jeffrey Settleman of the Massachusetts General Hospital Cancer Center in Charlestown and his colleagues treated tumour cells with cancer drugs.

The researchers concluded that patients with circulating tumour cells with more N - terminals than C - terminals had the androgen receptor variants.

Not exact matches

When placed at the site of a cancerous tumour in a rodent and «activated» by a scope with a light source, the compounds eradicated up to 100 % of cancer cells.

«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.

After 16 days, mice injected with the tumour - specific Th17 cells had barely detectable tumours, compared with mice injected with tumour cells alone.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.

These results were facilitated by the permanent cultivation of circulating tumour cells of patients with advanced SCLC in Vienna.

Cancer stem - like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).

The Lund University research team has looked at how cancer cells communicate with surrounding cells and how this encourages the development of malignant tumours.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - PeraWith this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perawith the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

«Patients with stage 1 non-seminomatous germ cell tumours have to make a difficult choice of whether to be watched or to receive chemotherapy to reduce the risk of relapse.

When chlorotoxin is tagged with a fluorescent dye, it will illuminate a tumour — a trick that makes the surgeon's job easier by helping to pinpoint cancerous growth and ensure that all the cancerous cells are removed and healthy tissue spared.

«The study of this type of tumours has been problematic up to now due to the lack of cell models and the appropriate animal models,» says CNIC researcher Juan Carlos Ramírez, who adds that the difficulty of generating these chromosomal translocations had limited the availability of cells with this mark of the disease.

Around 15 per cent of women with breast cancer have this form of the disease, in which tumour cells lack the three receptors that most drugs target.

According to Eckmann, «The special thing about these processes is that they involve known molecules with very long evolutionary histories, previously receiving attention as suppressors of tumour formation within the context of normal cell division.

Anne Goriely of the University of Oxford and her colleagues took tumour cells from men with benign testicular tumours and looked for specific mutations in the FGFR3 and HRAS genes.

«We could get some shrinkage of the tumours with other types of treatment we tried before, but we never got a complete cell kill,» he says.

Cell lines from human tumours did exist, but were considered unsafe: what if cancerous cells were transferred along with the vaccine?

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

The five year disease - free and overall survival rates for patients with high - risk malignant germ cell tumours remains less than 50 %, and so accurate diagnosis and monitoring is crucial to improving outcomes for patients.

The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS).

Tumours spread with the help of enzymes called matrix metalloproteinases (MMPs), which destroy the connective tissue between cells and organs, allowing tumour cells to break out of the original site and enter new ones.

Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strategy.

Cancer stem cells are strongly associated with the growth and recurrence of all cancers and are especially difficult to eradicate with normal treatment, which also leads to tumours developing resistance to other types of therapy.

KEYNOTE - 024 investigated the efficacy of pembrolizumab compared to standard of care with platinum - based chemotherapy in untreated patients with advanced NSCLC and high PD - L1 expression (defined as expression in at least 50 % of tumour cells).

Patients with TILs do much better because they already have cancer - fighting cells in their tumours.

Dr Sophie Roerink, joint first author from the Wellcome Sanger Institute, said: «We found mutational processes in these cancer cells that are just not seen in normal cells, leading to a huge increase in mutation rate for tumours compared with normal cells.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

The team worked on tissue from three patients with colorectal cancer, taking normal bowel stem cells and cells from four different areas of the tumours.

The discovery could pave the way for new treatments that are able to block cell signals switched on in tumours with low levels of PTEN.

This unfortunate and rare side effect of the biopsy provided Nicola Valeri at the Institute of Cancer Research in London and his colleagues with a kind of stopwatch — an exact point in time when a few cells left as the needle was withdrawn began their two year evolution into a tumour.

The researchers, working with cell cultures, first observed how individual tumour cells kill specific cells in the vascular wall, called endothelial cells.

Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brain.

In collaboration with Dr Gabriele Bonatz from the Augusta clinics in Bochum (Brustzentrum), Hatt's team confirmed the existence of TRPV1 in tumour cells in nine different samples from patients suffering from breast cancer.

It could have implications for HIV patients, both with and without cancer, as it can work on HIV reservoirs and tumour cells independently.

Therefore, «this finding may represent a future therapeutic strategic to combine with other strategies, such as immunotherapy, chemotherapy or inhibitors against specific signalling routes of the tumour cells.»

A team working at the Institute of Cancer Research and the Royal Marsden Hospital in London, in collaboration with scientists at the National Cancer Institute in Bethesda, Maryland, has found that tamoxifen also works by encouraging the cells surrounding a tumour to produce a «growth factor».

When tumours are treated with drugs, some resistant cancer cells can survive and continue to grow, leading to disease relapse.

«The high efficiency of the materials along with cheap, scalable synthesis makes them very attractive as next generation emitters for fluorescent lamps, LEDs and for biological imaging, for example for highlighting tumours or cell division.»

In the mice, the neuron - like cells did not grow as quickly as the original cancer cells, and analyses of the tumour tissue from patients show that those with a high level of the estrogen receptor have a better survival rate that those with a low.

When they loaded sperm cells with doxorubicin, a common chemo agent, and released them in a dish containing mini cervical cancer tumours, the sperm swam towards the tumours, killing 87 per cent of their cells within three days.

This has always been a worry with tissues produced from embryonic stem cells, as these have the capability to form tumours if any are left in their original state in the transplanted tissue.

When cancer cells interact with the walls of the blood vessels, EPHA2 is activated and the tumour cells remain inside the blood vessels.

When they injected the soil bacterium Clostridium [ck] novyi into the bloodstream of mice with tumours, it spread throughout the necrotic region, consuming living tumour cells as well as dead tissue.

Directly derived from patient tumours without any genetic manipulation, these new products provide the assurance of primary cells with long - term reproducibility and scalability

Discovery of synonymous cancer driver mutations in human tumours associated with changes in the splicing of oncogenes (Lehner group, Cell 2014).

She has worked in prestigious Institutions like the NIH - NCI, Bethesda, Md and the MIT, Cambridge, MA and developed an internationally recognised research profile in tumour cell migration and invasion with over 65 publications and 2 patents to her name.

These drugs can be targeted to interfere with signalling within the tumour microenvironment or activate other processes which will kill the cancer cells.

Combining a cancer therapy with a second drug therapy that helps suppress tumour blood vessels found in cancer cells can help to significantly reduce the spread of breast cancer tumours while also causing cancer cell death.