Sentences with phrase «tumour development»

In contrast, no Slc6a14 − / − female with PyMT transgene developed tumours at 3 months of age; however, at 4 months of age, small tumour nodules became detectable (Figure 2B), indicating a marked delay in mammary tumour development in PyMT - Tg mice as a consequence of Slc6a14 deletion.

Their experiments in pre-clinical models proved to be successful, confirming lower tumour development with the regulation of the proteins that affect production of VLDL (precursors of LDL) and uptake of LDL by receptors from the liver.

The Pan-Cancer consortium has included the tool in order to gain a more global view of the causes of tumour development.

Cancer cells feed preferentially on sugar (glucose) Glucose (from sugary and starchy foods) provides the prime fuel for cancer cells, so a diet lower in carbohydrate may therefore reduce tumour development or progression.

Lund University cancer researchers have discovered the path used by exosomes to enter cancer cells, where they stimulate malignant tumour development.

«We now know which cellular signalling pathways are involved in liver tumour development,» explains Heikenwälder.

The largest - ever study to sequence the whole genomes of breast cancers has uncovered five new genes associated with the disease and 13 new mutational signatures that influence tumour development.

Researchers have provided the first comprehensive compendium of mutational processes that drive tumour development.

Heparanase dysfunction is linked to the spread of cancers both through the breakdown of this matrix and via the subsequent release of «growth factors» — chemicals that promote tumour development.

Jessica Zucman - Rossi and her colleagues have shown that AAV2 leads to excessive expression of these genes which, according to the researchers, may favour tumour development.

Funded by the Medical Research Council, the team's work investigates tumour development in primary sclerosing cholangitis (PSC), a chronic liver disease where bile ducts inside and outside the liver shrink.

Mutations in p53, BRCA1 and chromosome instability are frequently associated with ovarian tumour development, but little is know about the cytoskeleton organisation in this type of tumours.

Consistent with the fact that cancer is one obvious pathology observed in elderly, we discover that persistent ROS increase tumour development and metastatic spread, by deeply modifying tumour micro-environment.

PyMT - Tg female mice on Slc6a14 + / + and Slc6a14 − / − backgrounds were monitored for breast tumour development.

The research is the 1st to make a comparison between the cancer - fighting potency of marine versus plant - derived omega - 3s on cancer tumour development.

In neoplastic cells butyrate inhibits proliferation at the crypt surface, the site of potential tumour development.

Low - carbohydrate and «ketogenic» diets «starve» cancer Low - carbohydrate diets mimic caloric restriction and ketogenic diets mimic starvation — and caloric restriction / starvation is linked to reduce tumour development and progression.

Now, free radicals and toxins are responsible for cancer and tumour development in most people.

«We've created a simple method to use chemotherapy while leveraging the biology of the tumour and our natural defence against foreign invaders to beat back tumour development with limited side effects,» said senior author Zhen Gu, PhD, associate professor in the joint UNC / NCSU Biomedical Engineering Department.

This could be due mostly to the hypoglycemia stalling the rate of tumour development.

The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.

«With this breakthrough it is possible to generate cell models with the same alterations as observed in tumour cells from patients, which will allow us to study their role in tumour development,» says CNIO researcher Sandra Rodríguez - Perales.

The alterations leading to tumour development are due to multiple changes in cell physiology and specifically in the cell genome.

When monocytes provide the wrong response, this could lead to severe outcomes ranging from inflammatory disorders to tumour development.»

The result is increased cell growth, also referred to as compensatory proliferation, which can lead to tumour development.

«We think there must be some external trigger that causes the tumour development,» she says.

In the context of cancer, a high level of ROS is a major player in tumour development and growth.

For example, researchers map genetic factors and study various genetic mutations in tumour development.

Marco Milán adds that, adds that there is a link not only between embryonic development and regeneration but also between the latter and tumour development.

Apigenin stopped formation of new blood vessels, thus delaying, and at times blocking, tumour development.