Sentences with phrase «tumour microenvironment»
The phrase "tumour microenvironment" refers to the surrounding area or space in and around a tumour where it grows. It includes various types of cells, blood vessels, and molecules that are present in this region. The interactions and conditions within this microenvironment can influence the growth and behavior of the tumour. Full definition
An anticancer agent, pyrvinium pamoate inhibits the NADH - fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments.
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Zebrafish provide a similar tumour microenvironment to humans, meaning fewer tests need to be carried out in mice and any future experiments in mice will have been optimised to have minimal toxicity.
«Stromal Function in the Evolving Tumour Microenvironment: A Role in Immune Modulation?»
These mice models allowed me to study the importance of STAT3 within the tumour and the overall tumour microenvironment.
An engineered tumour microenvironment provides new insights into cancer progression and drug responses.
Moreover, we have shown that lymph nodes draining a tumour (TDLNs) form part of the extended tumour microenvironment, adapting to tumour - derived signals.
From the tolerogenic tumour microenvironment, to the immune cells» intrinsic regulatory mechanisms, many hurdles stand in the way.
Although tumour microenvironment and inter-cellular communication between different cancer cells and other cell types, such as fibroblasts are important in carcinogenesis, most of the available molecular interaction data is intracellular.
· Cancer Growth and Spread — Healing Angiogenesis and Metastasis, discussing blood vessel development and growth factors, dysregulation including hypoxia and other blood supply stress responses in cancer and other diseases and how cancer cells travel and invade — metastasis via the complex tumour microenvironment — TME — comprised of immune cells, cytokines, growth factors, reactive oxygen species (ROS) and cancer - associated fibroblast (CAF);
«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»
The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.
The method was effective at making the tumour microenvironments susceptible to treatment.
Mimicking the tumour microenvironment (TME): Angiogenesis in tumour progression.
Since the myeloid cell kinase Hck is highly abundant in the tumour microenvironment and aberrant Hck activation results in spontaneous inflammation of the lung, we are now exploring whether this kinase also supports the growth of tumours.
These drugs can be targeted to interfere with signalling within the tumour microenvironment or activate other processes which will kill the cancer cells.
The cellular composition of the tumour microenvironment affects how well a tumour can grow and the extent to which it responds to targeted and immune - modulatory therapy.
We take a multidisciplinary approach to explore the mechanisms and evolution of stromal - mediated immune dysfunction in the tumour microenvironment and uncouple the immunoregulatory systems governing their suppressive function.
Her main fields of interest are angiogenesis, anti-angiogeneic gene therapy, chemoprevention, immunopathogenesis, invasion and metastasis, nanoparticles, nanotoxicology, the tumour microenvironment, and vascular biology.
The tumour microenvironment contains rapidly dividing rogue cells that compete for limited resources.