Sentences with phrase «tumour suppressor»

Mutations of the VHL tumour suppressor gene in renal carcinoma.

(2017) Tudor - domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.

Our work suggests that studying PI (3,4) P2 - regulated processes may reveal why PTEN is such a powerful tumour suppressor and may also help us to identify new therapeutic targets in PTEN - mutated cancers.»

Researchers at A * STAR's Singapore Immunology Network (SIgN) have discovered a new mechanism involving p53, the famous tumour suppressor, to fight against aggressive cancers.

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

Scuoppo, C. and Miething, C. and Lindqvist, L. and Reyes, J. and Ruse, C. and Appelmann, I. and Yoon, S. and Krasnitz, A. and Teruya - Feldstein, J. and Pappin, D. and Pelletier, J. and Lowe, S. W. (2012) A tumour suppressor network relying on the polyamine - hypusine axis.

The task is large but not insurmountable, says Rebecca: «One of the big problems with this cancer is that it doesn't have a recurrent driver gene — it's a disease dominated much more by multiple tumour suppressor genes being lost.

Tumour suppressor RNF43 is a stem - cell E3 ligase that induces endocytosis of Wnt receptors.

For example, whereas the p53 / p63 / p73 tumour suppressor family is holozoan - specific31, the HIPK kinase that phosphorylates p53 in the presence of DNA breaks is metazoan - specific, and the MDM2 ubiquitin ligase that regulates p53 appears as a eumetazoan feature.

BRCA2 tumour suppressor protein has a recognized role in the repair of DNA double strand breaks by homologous recombination.

Non-functional tumour suppressors or activated oncogenes can cause the development of cancer.

Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant - negative isoform, and loss of expression of the potential tumour suppressor p51.

Numb - negative breast cancers display enhanced Notch signalling and an overall poorer prognosis when compared with Numb - positive cancers; hence, we have suggested that Numb is a novel tumour suppressor.

PTEN is known as a tumour suppressor gene meaning that it typically slows the growth of cells and its loss can lead to cancer.

«Over 40 % of prostate cancers lose PTEN and some lose both PTEN and another tumour suppressor gene, INPP4B, but we didn't previously have a clear picture of how this affects tumour growth,» says IMED Biotech Unit scientist Sabina Cosulich, at AstraZeneca.

«Previous studies stated that LKB1 was a tumour suppressor in ovarian cancer, meaning that tumour cells need to get rid of LKB1 to cause cancer,» says Dr. Shepherd «but our work is in direct conflict with these studies, because we definitively show that ovarian cancer cells still have LKB1 and that this molecule allows ovarian cancer spheroids to change their metabolism, promote tumour cell survival and make them more resistant to chemotherapy.»

Inherited mutations of the tumour suppressor gene CDKN2A are the strongest known risk factors for familial melanoma and mutations in this gene also increase the risk of other cancers.

So in 1994 she started a 3 - year postdoc in the lab of Carol Prives at Columbia University in New York City, working on the tumour suppressor p53.

RUNX3 is a tumour suppressor gene that prevents the formation of tumours by binding to DNA.

These molecules have caused controversy due to the possible side effects of blocking Cdh1, which is considered a tumour suppressor.

Intriguingly, previous research found that RASAL2 was lost in some of the luminal type of breast tumours, where it acts as a tumour suppressor.

Rather than a tumour suppressor, we show here that RASAL2 actually acts as a cancer promoting molecule in TNBC.

BRCA1 is a tumour suppressor gene involved in DNA repair through homologous recombination and in preserving the integrity of the genome.

Tumour suppressors — whose protein products have a repressive effect on cell proliferation or promote apoptosis (programmed cell death), or both.

The adenomatous polyposis coli (APC) gene is a tumour suppressor gene, i.e. a gene preventing uncontrolled cell growth that could lead to the formation of a cancer tumour.

Ongoing projects aim to define the involvement of these two signalling axes in cancer and to investigate whether the endocytic function of Numb is relevant to its tumour suppressor function.

Therefore, Numb controls both an oncogenic pathway (the Numb: Notch axis) and a tumour suppressor pathway (the Numb: p53 axis).

More recently, our studies on the endocytic protein, Numb, have revealed that it is a tumour suppressor in breast cancer (2).