Sentences with phrase «tumour type in»

Researchers from SciLifeLab / Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumour type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients.

An early sign that this might be the case came from a small clinical trial testing a new drug that has been developed without a particular tumour type in mind.

Researchers from Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumour type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients.

Not exact matches

A doctor exams mammograms, a special type of X-ray of the breasts, which is used to detect tumours as part of a regular cancer prevention medical check - up at a clinic in Nice, south eastern France January 4, 2008.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

«However, many patients do not respond because myeloid derived suppressor cells (MDSCs), a type of inhibitory cell, are present in the tumour microenvironment.»

The experimental drug nintedanib, combined with standard chemotherapy with paclitaxel, causes a total remission of tumours in 50 % of patients suffering from early HER - 2 - negative breast cancer, the most common type of breast cancer.

In future, levels of a modified protein present in many types of tumour may help predict whether it is likely to spreaIn future, levels of a modified protein present in many types of tumour may help predict whether it is likely to spreain many types of tumour may help predict whether it is likely to spread.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.

Decitabine is approved by the U.S. Food and Drug Administration to treat myelodysplastic syndromes and leukemia, and for use in clinical trials for several types of solid - tumour cancers including colorectal.

Tumours which carry mutations in KRAS genes (40 % of CCR) or BRAF genes (between 5 and 15 % of these types of cancers) are ineffectively treated and have poor prognosis.

Seen in this light, a variety of tumour types can originate from the same organ.

The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS).

NGS was possible in 117 (76.5 %) patients and revealed that 66 patients had «all RAS» wild - type tumours with no mutations in KRAS; NRAS; BRAF; or PIK3CA genes and 51 patients had tumours harbouring a mutation in at least one of these genes.

KRAS exon 2 mutations were found in approximately 15 % of the tumours that were originally identified as wild - type.

The team used five types of antibiotics — including one used to treat acne (doxycycline)-- on cell lines of eight different types of tumour and found that four of them eradicated the cancer stem cells in every test.

«Some of these genes were either increased or decreased in the area of the tumour, no matter the type of breast cancer, and this is important because within the patterns we identified were predictable alterations.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

The same approach may be useful for boosting the effects of chemotherapy in other types of solid tumour with high levels of stroma, Ganss says.

The CNIO researchers show that cell defects caused by the inhibition of Cdh1 are independent of the presence of the p53 molecule, which is mutated in different types of tumours.

The team also found that there were also cases of other cancer types in families with these hereditary mutations such as leukemias and brain tumours.

While it is present on a number of different types of cells in the body, it is expressed at higher levels on metastatic tumour cells, including those which have spread from the lung.

Although most of the work has been carried out using in vivo studies, Asst Prof Gasser has been collaborating with Dr Joanne Ngeow at the National Cancer Centre Singapore to characterise the process in different types of human tumours.

It is known that a diet rich in fat can increase the risk of developing prostate cancer, and that obese people are more prone to develop this type of tumour.

They analysed about a million different cell mutations in more than 7,000 tumours from the Cancer Genome Atlas covering 24 types of cancer.

IBM's Watson, the supercomputer that famously won the TV quiz Jeopardy! in 2011, is analysing gene sequences from the most aggressive types of brain tumours.

The DNA of BKV has been discovered in several types of human cancers including prostate tumours, and mouse studies suggest the virus can trigger cancer.

Intriguingly, previous research found that RASAL2 was lost in some of the luminal type of breast tumours, where it acts as a tumour suppressor.

In recent years, researchers have discovered several ways of using genome sequencing of tumours to predict whether an individual cancer patient will benefit from a specific type of medicine.

In future, other switches could be identified in other types of tumour celIn future, other switches could be identified in other types of tumour celin other types of tumour cell.

So they then went on to study the genomes of a type of paediatric brain cancer characterised not only by a mutated polymerase — like in the tumours previously examined — but also by an inactivated repair system.

It recognises the four most common types of cancer — prostate, lung, colon and breast cancer — at a very early stage, namely when the level of calcium in the blood is elevated due to the developing tumour.

In the genome of tumour cells of 11 patients, the scientists observed the insertion of a viral DNA segment from adeno - associated virus type 2, known as AAV2.

Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, Glover T, Collins FS, Weslon A, Modali R, Harris CC, Vogelstein B. Mutations in the p53 gene occur in diverse human tumour types.

We see extensive variability in genomes among tumours of different tissue types, among different patients within a tissue type and among subclones within a given patient's cancer.

Perfusion of microvessels in Tie2PEKO mice was further confirmed by similar extent of hypoxic areas as compared to tumours growth in wild - type mice (Supplementary Fig. 12b).

Dr Steve Pollard and his team are developing potential new treatments for the most common type of brain tumour in adults, known as glioblastoma multiforme.

Breast and ovarian tumours lacking one of these two genes are more sensitive to a new - generation chemotherapy, the PARP inhibitors, which is revolutionising drug treatments in this type of cancer.

And Dr Sara Erridge is running a clinical trial in Edinburgh to find the best way to treat a type of brain tumour called glioma.

To help plug this diagnostic hole, Rebecca is leading the OCCAMS trial, a CRUK - funded multicentre study which is part of the International Cancer Genome Consortium (ICGC) global project to generate a comprehensive catalogue of genomic abnormalities in 50 tumour types.

The team looked into whether NKG2D's roles in chronic inflammation and cancer could help tumours to grow in these types of cancer.

«It tells you about the ecosystem of the tumour», Simona says, «using fluorescent markers, we can label many specific cell types and structures within the brain in the vicinity of the tumour, and look not just at the tumour cells but how they interact with their surroundings.

«We showed that there are markers on these stomach tumour cells that indicate they would be responsive to a type of immunotherapy called immune checkpoint inhibitors, in particular anti-PDL1 immunotherapy, which is already used with great success in the treatment of melanoma and certain other cancers.

We found 1,098 genes in the sequence, of which 99 encode proteins expressed in testis and in various tumour types.

«It's fascinating that it's so complicated», says Gerard, «there is a code we don't yet understand that differs from tissue to tissue — the number of chemokines and cytokines is distinct in each tissue type and the types of cells that enter and exit the tumour also differ».

Mutations in p53, BRCA1 and chromosome instability are frequently associated with ovarian tumour development, but little is know about the cytoskeleton organisation in this type of tumours.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criteria

(A) Demonstration of Slc6a14 mRNA up - regulation in PyMT - driven mammary tumours in mice; N, mammary tissue from wild - type mice; T, mammary tumour tissue from PyMT - Tg mice.

By comparing the conversations, the researchers made the surprising discovery that similar reactions were taking place in different tumour types.

Analysis of transcriptomes in tumour tissues from wild - type mice and Slc6a14 - null mice indicated no compensatory changes in the expression of any other amino acid transporter mRNA.