Not exact matches
To trace the source of the problem, the scientists analyzed what genes in the
glia from people with schizophrenia were
turned on and off.
Glia - making cells from people with schizophrenia also mostly failed to
turned into astrocytes, which help neurons connect and determine when those connections, or synapses, fire.
A study in the International Society for Stem Cell Research's journal Stem Cell Reports, published by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2
glia, to
turn into neurons in the injured cerebral cortex of adult mice.
Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as
glia to
turn into neurons.
They
turn into another kind of
glia, called astrocytes.
They release more and more neurotoxic chemicals, and those, in
turn, excite neurons, creating a feedback loop: overstimulated
glia cause more and more inflammation, which activates stronger pain signals from neurons and amplifies pain.
He still was not a neural engineer, but he was getting closer, because as it
turns out, there is another really important thing to know about
glia — they protect the brain from foreign intruders.