Sentences with phrase «turn on cancer»

When activated by progesterone, progesterone receptors bind to and «reprogram» estrogen receptors, transforming them from agents that turn on cancer - promoting genes to ones that turn on genes which slow down or even reverse the growth of cancer cells.

So, what we did in this experiment here, we gave 4, 6, 8, 10, 12, 14, 16, and so forth and we learned something really interesting which turned out to be really quite a momentous idea later because in terms of this application to humans, in terms of this application to nutrition and health in general, what you can see in this particular presentation is that protein fed up to a level about 10 % of the calories, it..., it doesn't..., it doesn't turn on the cancer, but where..., when AS SOON AS THE PROTEIN BEGINS TO EXCEED 10 % THEN IT TURNS ON THE CANCER

Similar to the problem of traditional gene therapy hitting the wrong spot, ZFNs could make cuts in places where they weren't supposed to and turn on a cancer gene.

The same seems to be true of the gene switches that turn on cancer cells.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Cancer can happen if a genetic modification accidentally turns on a cancer gene or turns off a cancer - suppressing gene.

I mean, we knew up until this point that 20 % of the diet is protein, it turned on cancer, 5 % did not.

When I think of helpful ways nutrients can affect cancer, I think of nutrients triggering gene expression, turning on cancer supressor genes or turning off cancer promoter genes.

Not exact matches

Talk about turning the tables on cancer!

«I hope that someday all of you on the advisory committee can tell your families for generations that you were part of the process that ended the use of toxic treatments like chemotherapy and radiation as standard treatment, and turned blood cancers into a treatable disease that even after relapse most people survive.»

Basically, CAR - T therapy involves taking a patient's own immune «killer» T - cells, inserting new genetic code into those cells which turn them into cancer - hunters that can home in on malignant B - cells (another kind of immune cell), and then pumping these specialized leukemia - busting cells back into the patient.

He was an American original, in a way only an immigrant can be — a thick - accented, scientist - turned - businessman who spoke forcefully and wrote gracefully in English on topics as varied as his management philosophy, his battle with prostate cancer, and his story of coming to the U.S. Grove was famously profane, harsh, driven, and driving.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

Their advertising openly traded on the cancer survivor's inspirational message, and in turn, yellow Livestrong bracelets became a trendy fashion accessory that raised millions for charity.

How many Newts pervade the GOP who disgustingly take the moral high ground by campaigning on «family values» then turn around and abandon a wife with cancer?

I invoke the air in rage, am like a cancer in a cage» only myself to burn, to burn; mere glass and sun on an empty stage.Pick and spade, curse and yearn» agatefulls are struck and turned, one by one and year by year, until the hollow has been earned.Now the reckoning is near, now the....

As it turns out, health problems such as childhood diabetes, obesity, bowel disease, osteoporosis, heart disease, cataracts, colic, ear infections, hyperactivity, and cancer, on the rise in both children and adults, can be strongly linked to infant feeding choices.

Disgraced former state Senate majority leader Malcolm Smith was scheduled to turn himself in last week so he could begin his seven - year jail sentence on corruption charges, but he got his surrender date pushed back more than six weeks by claiming that he must be checked for prostate cancer by his own doctor before prison, court papers show.

Chronic cigarette smoke exposure, as noted in many human cancers, tends to block these cell maturation genes from properly turning on, says Baylin.

The findings, published in Proceedings of the National Academy of Sciences (PNAS), define a mechanism in which the oncogenes turn on a protein called RSK2 that is required for cancer cells to move.

They show that turning on this signaling hub activates the movement of the cancer cells.

«In addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.»

Fostamatinib's effect on microtubules seems to increase the stabilizing effect of paclitaxel, even in resistant cells, which in turn may prevent cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School of Medicine and co-author of the study.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

Although serrated polyps usually are associated with colorectal cancer, it turns out that such polyps are themselves not dangerous, according to a Norwegian study released this week in BMJ Gut, a journal on gastroenterology & hepatology.

«We can use different approaches to reverse methylation,» she says, «turning silenced genes back on, and seeing whether we can prevent the tumours from occurring or treat the cancer after it has appeared.»

Mariela Jaskelioff and her colleagues at the Dana Farber Cancer Institute in Boston, Massachusetts, engineered mice with short telomeres and inactive telomerase to see what would happen when they turned the enzyme back on.

When the cancer microRNAs were present and able to turn the DNA circuit on, cells were unable to grow.

«We also know that this RhoB pathway, once turned on, can stimulate the expression of two proteins: p21, which prevents cells from replicating, and BIM, which induces cell death — both of which can help stop cancer growth.»

Pigments that turn caustic on exposure to light can fight cancer, blindness and heart disease.

An estimated 90 percent of all malignant tumors use telomerase to achieve immortality, and various proposed cancer therapies focus on turning down the production of telomerase in tumors.

siRNAs are very small molecules that carry genetic information to cells, but unlike DNA that can turn genes on, siRNA interferes with the production of particular proteins and can turn cancer genes off.

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

By switching Apc on, researchers turned swelling mobs of mouse cancer cells (above) back into normal intestinal tissue (below).

«In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine.

«What he showed us is turning the immune system on isn't enough; the crucial step is to make sure it doesn't turn itself off,» says Antoni Ribas, director of the tumor immunology program at UCLA's Jonsson Comprehensive Cancer Center.

On the flip side, turning up expression of these genes or their pathways could help researchers grow new intestinal tissue to replace tissue destroyed by diseases such as inflammatory bowel disease or radiation treatment for cancer.

Commenting on the findings, Professor Martin said: «Understanding how cancers turn on the wound - healing response has been mysterious, so we are very excited to find that certain cancers exploit TRAIL for that purpose.»

Some chemicals may leave people vulnerable to diseases like cancer and diabetes, not by mutating genes but by turning them off or on at the wrong time

Horvath and Tell observed that there are many clearly visible patterns of common gene expression — where certain genes are turned on and certain genes are turned off — in the basal - like cancers.

In four tumors, the vector mapped to a section of chromosome 12 and turned on several genes implicated in cancer, the team reports tomorrow in Science.

Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

But in some cancers — prostate, pancreatic, ovarian and lung in particular — the hedgehogs somehow turn back on, and force uncontrolled cell growth: cancer.

«The NanoFlare turns on a light in the cancer cells you are looking for,» said Thaxton, an assistant professor of urology at Feinberg.

Galectin - 9 turns on dectin - 1, shifting macrophages to the M2 pathway and preventing them from fighting cancer, say the researchers.

«There is increased interest in enhancers and eRNAs in the cancer biology world because defective enhancers can cause too much or too little of a protein to be made, or can cause the coding region to be turned off or on, or can make a protein at the wrong time,» Berger said.

Around the turn of the century, though, researchers noticed that women on HRT had an increased risk of heart disease, uterine and breast cancers, and strokes, and doctors generally stopped prescribing the drugs.

Toone first got turned on to the value of research administration during his postdoc at the Imperial Cancer Research Fund (ICRF; currently Cancer Research UK) in London, UK.

The light - activated genetic switch could be used to turn genes on and off in gene therapies; to turn off gene expression in future cancer therapies; and to help track and understand gene function in specific locations in the human body.