Sentences with phrase «turn other genes»

TBX5 produces a protein of the same name that acts as a critical switch, helping to turn other genes involved in heart development on or off.

The three factors, Gata4, Mef2c, and Tbx5 (GMT), work together to turn heart genes on in these cells and turn other genes off, effectively regenerating a damaged heart with its own cells.

The ATF6 protein is a transcription factor, meaning it helps turn other genes «off» or «on,» depending on what's needed by the cell.

However, in the presentations, speakers for both teams said that two stretches of the gene code for so - called zinc fingers — protein structures that insert themselves into the grooves of DNA — suggesting that the encoded protein probably turns other genes on and off.

In most cases, the genes responsible for these processes are known as «transcription factors» — meaning that they are responsible for turning other genes on and off.

Ko first cloned the human GT198 gene while a postdoctoral fellow at Harvard Medical School, and subsequent studies by her and others have shown it has multiple roles that also include regulating stem cells, cell suicide and turning other genes off and on.

Not exact matches

Using the gene - editing tool CRISPR - Cas9 to turn off certain genes in a mouse zygote as well as other new techniques to enrich the pluripotent stem cells of a rat, the group managed to grow various rat organs (a pancreas, heart, and eyes) in a mouse embryo.

However, if I was an ancient Israelite, and I saw things like the Red Sea parting, staff turned into snakes, and the Shekinah glory, and prophets predicting specific future events with 100 % accuracy, and other nations setting their face against Israel to destroy her and / or engaged in human sacrifice, and they weren't typical humans but were actually a group of hybrids like the Nephalim or the Rephaim that were polluting the gene pool to try to foil God's plan of ultimately bringing a Messiah to save all mankind one day, and God wanted them to repent and sent them warning after warning, and they refused, and God commanded me thus....

For a very small number of genes, though, people inherit only one working copy; the other copy is turned off, forever silenced.

In other words, the big pig centers in the midwestern parts of the country become pools of various strains of the virus, giving it more opportunities to swap genes and potentially turn into more harmful, more easily transmitted varieties that could go pandemic in people.

The researchers are now investigating whether the guide RNA turns on each of these genes individually or whether it activates one or more regulatory genes that then turn the others on.

«In addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.»

Further genetic screening revealed that many of the genes turned on by this guide RNA strand are chaperone proteins, which help other proteins fold into the correct shape.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

There's no way to cram the dystrophin gene into a virus to do traditional replacement gene therapy, but researchers have found that turning on other genes can compensate and bulk up muscles.

He had shown in previous work that a certain gene turns off limb development in snakes — making snakes essentially limbless four - legged animals — and he wanted to compare that finding in other species.

In addition, they also found a second — and possibly more important — role that they hadn't expected, Maniatis says: IKKε was actively involved in turning on other antiviral genes within a cell.

Only a decade later was it confirmed to bind to DNA and turn on the expression of other genes aimed at healing cell damage.

If epimutations can happen, the same effect should turn up in other genes.

He's optimistic that the gene will work in other plants as well, such as broccoli, which ethylene turns soft and yellow.

Since even the DNA for photosynthesis is missing, Davis and his colleagues turned to mitochondrial and other slowly evolving genes.

Other genes can prompt skin cells to turn directly into neurons or blood cells.

But the team cautions against screening for the gene and others like it to identify potentially violent and impulsive individuals, because only a fraction of carriers turn to violence.

Aiolos is a member of a class of proteins called transcription factors — proteins that control which genes are turned on or off by binding to DNA and other proteins.

The results, which focus on two choices near the start of embryo formation, show that, when cells are making decisions about what to become, there is greater variation in the activity of the genes in different cells — the same genes may be turned on in some cells and off in others.

They homed in on one gene that was expressed in the brain and significantly turned down in the PTSD - like mice when compared to other mice.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

As with all of our other genes, the DNA that encodes the telomerase enzyme is present in all of our cells — but because it's needed only after quite a few cell divisions have occurred, it's not needed in most cells for most or all of the time, so it's turned off.

That in turn could help determine when humans interbred with archaic hominids on other continents — such as Neandertals in Europe and Denisovans in Asia — whose genes linger in the DNA of some modern people (SN: 6/13/15, p. 11).

Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.

The IL - 15R - alpha gene is expressed in tissues other than muscle, and no one knows the full consequences of turning the gene off.

Activation of NOTCH1 by blood flow causes a domino effect, triggering numerous other genes in the network to turn on or off, resulting in suppression of inflammation and calcification.

Banfi says that the related genes expressed in a variety of tissues suggest that reactive oxygen species will turn up in other surprising roles.

What we were surprised to find out was that the real differences we could detect in terms of when we did the swap experiments to say which yeast could outperform the other — what we learned was that the GAL1 gene, that the part [of] that, the DNA sequence is outside of the GAL1 gene, it acts as a switch to turn up or turn down GAL1 expression, that had evolved considerably from the ancestral situation; and same for the GAL3.And then what had happened was that each function had been optimized, that GAL3 had sort have been tuned to be sort of a loosely regulated kind of available anytime sensor of galactose and GAL1 had evolved to be an incredibly tightly regulated, in fact, it's the most tightly regulated gene you know of in yeast.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

This program normally shuts off after embryonic development, but occasionally — for reasons not yet known — crestin and other genes in the program turn back on in certain cells.

«Small alterations on these histones act as a molecular switch to turn certain genes on and others off,» Thomas said.

But as you said, as an individual eats a high - fat diet or is exposed to other types of environmental exposures, the ability of the liver to adapt involves turning on and turning off certain liver genes to control the liver's activity, and that's mediated through these epigenetic mechanisms that modify the activity of established liver genes.

The gene, they reported last March, turns out to be an organizer gene: it switches other genes on and off, and in so doing tells cells at the front end of the embryo to become a head.

Steve: The changes were in those other sequences that determine how those genes get expressed, when they get turned on and off and in what numbers.

How many other genes congregate like this when they get turned off?

The protein, called XBP - 1s, turns on genes that direct the assembly of other proteins that keep insulin function working correctly in the cells.

(Because of the strong sequence similarities between the two genes, the scientists have not yet been able to turn off one without the other, so differences between their functions are still unclear.)

Some binding proteins work by turning on the Short - root gene and others by shutting it down.

The team's results suggest that, even though there is no SRY gene in T. osimensis, the regulatory genes that normally turns on are present and operate as they do in other placental mammals.

One strain may show likenesses in the appearance of tumors, while others may have similarities in genes that are turned on.

Harmful chemicals, stress and other influences can permanently alter which genes are turned on without changing any of the genes» code.

Chimp Coordinators, on the other hand, easily turn on chimp genes but don't work as well for human genes.

Gene therapy has come a long way since, and Nina's case, along with others, mark a turning point: researchers seem to have found a safer way of manipulating our genes.

(The markers include genes and other DNA components, such as parts of the DNA that turn proteins on or off, and cellular components that play a role in regulating genes.)