Sentences with phrase «turning on genes»

Controls gene expression by turning on some genes while turning off the expression of other genes.

These proteins, called transcription factors, work by changing which genes are expressed in the cell, turning off genes associated with skin cells and turning on genes associated with stem cells.

For GR - targeting drugs, the side effects are thought to come from turning on genes involved in processes such as metabolism and bone growth, while the desired anti-inflammatory effects result mainly from turning inflammatory and immune system genes off.

In an earlier study, Wahl and his team discovered that Mdm2 and Mdmx cooperate to prevent p53 from being activated, with Mdm2 being primarily responsible for degrading p53, while Mdmx is more effective at preventing p53 from turning on genes.

Then, the researchers compared that RNA, looking for differences in the ways the lizards were turning on genes.

Roving parts of the genomic machine can better access the open sections, and so have a better chance of turning on the genes located there.

In addition, the analysis provided some hints about how chemotaxis evolved from a simple signaling network that responds slowly to environmental cues — primarily by turning on genes — to a multiprotein system that can quickly alter a cell's course.

The artificial cells showed that they «heard» the natural cells by turning on genes that made them glow.

They found that the more efficient a mutant was at turning on genes, the more time it spent flipped into the active shape, they report in the 23 March issue of Science.

Experiments with these mice suggest TREM2 is important for steering microglia toward amyloid and turning on genes that rev up their cleanup capabilities.

The special type of phytonutrients found in cinnamon have an amazing ability to stabilize blood sugar levels, prevent fat - storing insulin spikes, protect the body from damaging free - radicals, and, most amazingly, actually have the ability to «turn on genes» within our body that produce highly protective anti-inflammatory substances.

PER and TIM block the ability of CLOCK to turn on these genes at the same time as they are producing the oscillations of the central feedback loop — setting up extended patterns of cycling gene activity.

«Could turning on a gene prevent diabetes?.»

They also attached an inducible promoter, which enabled them to turn on the gene to make more GLP1, as needed, by exposing it to the antibiotic doxycycline.

Being able to precisely turn on genes within an animal and influence the animal's health is a «great advance,» Gersbach says.

Researchers called them induced pluripotent cells, which are created by enticing cells to turn on genes normally found in embryonic stem cells.

Deisseroth has also refined methods for delivering the opsin genes, typically by inserting into a virus both opsin genes and DNA to turn on those genes.

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

This «demethylation» turns on genes that direct stem cells to mature, and to start a count - down toward self - destruction as part of normal turnover.

Exposure to the light makes the bacteria turn on a gene that kicks off a chemical reaction, producing a corresponding red, green, or blue pigment.

«We may need to focus on drugs that modify chromatin in a way that decreases methylation,» Grayson says, to «turn on genes that are missing in the schizophrenia.»

«In this current study, we've shown that by opening the TRPV1 channel to allow calcium ions to enter the cell, we can turn on a gene.

There, a protein turns on genes that help bile acids break down the cholesterol.

Zeroing in on NANOG, the scientists found that low oxygen conditions increased NANOG's mRNA levels through the action of HIF proteins, which turned on the gene for ALKBH5, which decreased the methylation and subsequent destruction of NANOG's mRNA.

Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.

But the researchers discovered that after an overdose, liver cells turn on a gene that shuttles desperately - needed cysteine into the cell but pumps glutamate out, until eventually glutamate levels start to run low, too.

They found evidence that the drug turns on the gene that produces the protein «FOXO,» a master regulator of stress resistance in many organisms that is often central in longevity studies.

Biologists are learning how to turn on the genes that make our cells young.

Hong - Zhong Zhang and colleagues at the University of California at San Francisco deciphered the signaling system between a protein in a resistant staph cell that keeps watch for beta - lactams and a second protein that it tells to turn on the gene for beta - lactamase when the drugs are present.

The fat, they found, was required to turn on genes that protected the animals and cells from Huntington's disease, revealing a new pathway that could be harnessed to treat the disease.

The protein, called XBP - 1s, turns on genes that direct the assembly of other proteins that keep insulin function working correctly in the cells.

By adding acetyl groups to the histones that package DNA, they help turn on genes.

It's a marriage of two technologies, one that uses bursts of light to turn on genes, and one that enables people to control external devices, such as computer cursors or robot arms, with their minds using «brain - computer interfaces.»

Specifically, when RXR was stimulated by Bex, it turned on genes needed to produce brown fat and turned off genes linked to white fat or muscle.

The sulforaphane induced both types of cells to increase their levels of a protein that turns on genes that promote detoxification of carcinogens, like those found in cigarettes, and protect cells from cancer.

«We're looking for multiple mutations across tumors, mutations that turn on genes and promote cell growth,» Dias - Santagata says.

In turn, hyper - activated TLR3 turns off genes that stem cells need to specialize into brain cells and turns on genes that trigger cell suicide.

In 2003, Sun and colleagues had discovered a so - called transcription factor, which turns on genes involved in making starch.

The senior researchers of the study, Martin Eilers and Juha Klefström are excited about the concept that Myc's ability to turn off rather than turn on genes is a key to cell death: «It is much easier to bring cellular activities down than up with the existing drugs.

Katrin Wiese explains, «Our mutant Myc turned on genes without a hitch but it had difficulties to turn genes off.

Two enzymes in the neurons activate proteins called transcription factors that turn on genes.

The work involves using an engineered chunk of DNA instead of a virus to introduce factors into a cell that will turn on genes needed for pluripotency.

Microglia surround TDP -43-filled neurons and turned on genes to make proteins that help them attach to the sick cells and induce a process called phagocytosis that envelops the mutant proteins for disposal.

HNF - 4α is found mostly in liver and pancreatic cells, where it turns on genes needed by those organs and keeps other, unnecessary genes off.

NF - κB is transcription factor that, among other functions, turns on genes involved in inflammation and immune response, and can be activated in the presence of pro-inflammatory cytokines.

Previously, Semenza's team generated a virus that carries the gene encoding an active form of the HIF - 1 protein, which turns on genes necessary for building new blood vessels.

The reprogramming factors turn off or turn on gene expression at these spots accordingly.

As a powerful tumor suppressor, p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of cancer.

Typically, a common DNA virus enters the cell's nucleus and turns on genes to replicate its own DNA.

That allows the two other genes, Sox2 and Oct3 / 4, to bind more easily to the DNA and turn on genes that return the cell to a pluripotent state.