Sentences with phrase «type immunopathology»

While increased titers of serum antibody were induced and no virus was detected day two after challenge in most animals, the Th2 - type immunopathology occurred after challenge, and the immunopathology seen earlier after vaccination with the DI whole virus vaccine was seen again.

Histopathology seen in animals given one of the SARS - CoV vaccines was uniformly a Th2 - type immunopathology with prominent eosinophil infiltration, confirmed with special eosinophil stains.

To be certain the Th2 type immunopathology was elicited by the S protein vaccine in our studies and in hopes a greater immune response would result from higher dosages of the vaccine and induce greater protection against infection as well as reduce or prevent the immunopathology, our experiment 2 used up to 9 µg of the S protein for immunization.

In contrast to our results, those studies did not find clear evidence of the Th2 type immunopathology on challenge of mice given a vector vaccine for the S protein.

As indicated, strong animal model evidence indicates expression of the N protein by SARS - CoV vector vaccines can induce sensitization leading to a Th2 — type immunopathology with infection.

Nevertheless, the Th2 - type immunopathology pattern was seen only in animals given an inactivated vaccine earlier.

Those challenged animals exhibited infection similar to unvaccinated animals as well as Th2 - type immunopathology.

That lung disease exhibited the characteristics of a Th2 - type immunopathology with eosinophils in the lung sections suggesting hypersensitivity that was reminiscent of the descriptions of the Th2 - type immunopathologic reaction in young children given an inactivated RSV vaccine and subsequently infected with naturally - occurring RSV [32]--[33].

However, challenge of mice given any of the vaccines led to occurrence of Th2 - type immunopathology suggesting hypersensitivity to SARS - CoV components was induced.

Not exact matches

In an effort to determine whether an adjuvant that induced a bias for a Th1 - type response would protect and prevent the immunopathology, we initiated an experiment where the DI PBS suspended vaccine was adjuvanted with Freund's complete adjuvant, a Th1 - type adjuvant.

The vaccines were evaluated for immunogenicity and efficacy; however, because of the previous report of immunopathology on challenge of ferrets and nonhuman primates that had been vaccinated with a whole virus adjuvanted vaccine and mice that had been vaccinated with a VLP vaccine, the primary orientation was to assess for immunopathology among animals in relation to type of vaccine, dosage, serum antibody responses, and virus infection.