Sentences with phrase «type mice developed»

After intracerebral injection of the recombinant prion, wild - type mice developed neurological signs in ~ 130 days and reached the terminal stage of disease in ~ 150 days.

Not exact matches

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

Hoping to develop a more potent approach, medical oncologist Ron Levy of Stanford University in Palo Alto, California, and colleagues used mice to test the cancer - fighting capabilities of some 20 molecules, including several types of antibodies that activate immune cells.

At about 24 weeks, however, seventy percent of them developed spontaneous colitis, while none of the wild - type mice did.

Coussens and her U.C.S.F. colleagues Douglas Hanahan and Zena Werb reported in 1999 that mice engineered with activated cancer genes but without mast cells (another type of innate immune cell) developed premalignant tissue that did not progress to full malignancy.

Researchers developed a new type of cell transplantation to treat mice mimicking a rare lung disease that one day could be used to treat this and other human lung diseases caused by dysfunctional immune cells.

Knocking out a particular gene in muscle lets mice run twice as far as normal; knocking out the same gene in fat cells allows the animals to put on weight without developing type - 2 diabetes.

When the scientists blocked Treg cells from accumulating in the fat by targeting a molecule that the immune cells require, mice no longer developed type 4 diabetes in old age.

In the new study, the researchers found that the offspring of pregnant mice that consumed a high - fat diet developed liver fibrosis, a type of tissue scarring that is a sign that more serious disease will develop.

The researchers found that Zika targeted two specific cell types in mice: spermatogonia, which make sperm, and Sertoli cells, which are involved in helping sperm develop and sheltering them from the blood and immune system, building what's called the blood - testis barrier.

The wild - type mice didn't develop colitis, but showed low - grade inflammation in their intestines and several features of metabolic syndrome: slight weight gain, increased body fat and food intake, and higher blood sugar levels, which indicate poor glucose regulation associated with diabetes.

Additionally, when the same type of mice on the same diet for 45 weeks, at which point they would have already developed HCC, showed no signs of HCC after treatment with AIM, indicating that cancerous cells were being destroyed.

When the deformed pancreas proteins were injected into mice without type 2 diabetes, the animals developed symptoms of the disease, including overly high blood sugar levels, the researchers report online August 1 in the Journal of Experimental Medicine.

The mouse version of the IAPP protein can not clump — and mice don't develop type 2 diabetes, a sign that the accumulation of IAPP is important in the development of the disease, says Soto.

Haruko Obokata of the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan, and colleagues at other Japanese institutions and at Harvard Medical School in Boston reported that simply subjecting blood cells from newborn mice to a moderately acidic environment for 25 minutes and then tweaking culture conditions could generate pluripotent stem cells capable of developing into nearly all of a body's cell types.

The researchers developed mice that did not have SOD1 in their muscles, though it was still present in other types of cells.

Acute alcohol - treated FOXO3 - deficient mice developed more severe liver injury than that of wild - type mice, and this was attributed to decreased expression of autophagy - related genes.

While mice that received ISO - 1 remained healthy, the control group developed high blood sugar — a key marker for Type 1 diabetes.

To determine whether treatment with Osteolectin could reverse bone loss after the onset of osteoporosis, the CRI research team used mice that had their ovaries removed to model the type of osteoporosis that develops in postmenopausal women.

The lab mice in the study that had Type I diabetes demonstrated an impressive level of control over their blood sugar for more than two days following the injection of the newly developed insulin / glucosamine compound.

Mice have two types of BAT: constitutive BAT (cBAT), which develops before birth; and recruitable BAT (rBAT), which is found in WAT and skeletal muscle.

Their research, the scientists suggest, indicates that the adult mouse pituitary includes two similar — but not identical — types of hormone - producing cells: some that grew in the developing embryo, and some that appeared later.

In this image, a novel type of human stem cell is shown in green integrating and developing into the surrounding cells of a nonviable mouse embryo.

In contrast, irradiated p21 - deficient mice survived longer than irradiated wild - type mice, and only one - third (32 %) of them developed tumors (Table 3 ⇓; Fig. 3 ⇓).

We have also examined the constitutive levels of apoptosis in the thymic lymphomas developed in p21 - null mice and in wild - type mice after irradiation (Fig. 4) ⇓.

Interestingly, p21 - deficient mice did not develop T - cell lymphomas, which is one of the most common tumor types in p53 - null mice (36, 37, 38).

Scientist Shomyseh Sanjabi, PhD, joined the Gladstone Institutes 7 years ago, and she brought with her a special type of mice that develop inflammatory bowel disease (IBD).

To circumvent this delay, scientists inject cattle tissue into «wild - type,» or normal, mice to see if they develop the disease.

It is interesting to note that p21 - deficient mice did not develop T - cell lymphomas, which is one of the most common tumor types in p53 - null and p19ARF - null mice (36, 37, 38, 42, 43).

Using her mouse model, Stromnes watched as pancreatic tumors developed and noticed that one type of regulatory immune cell stood out.

They found that when an MS - like disease was induced in mice genetically engineered to be deficient in Tob1, the mice had significantly earlier onset compared with wild - type mice, and developed a more aggressive form of the disease.

Interestingly, when parental d42m1 sarcoma cells were transplanted into wild - type mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).

In an apparent world first, Japanese researchers have succeeded in producing intestine from induced pluripotent stem (iPS) cells in mice, which can develop into various types of cells in the body.

SAN FRANCISCO, CA — Scientist Shomyseh Sanjabi, PhD, joined the Gladstone Institutes seven years ago, and she brought with her a special type of mice that develop inflammatory bowel disease (IBD).

Given that there are millions of cells in a typical skin biopsy (researchers used skin from either the end of the tail or from the ear of the mouse), that translates into thousands of stem cells, each one capable of developing into any cell type of the body.

To define the relationship between neuropeptide signaling and aging, we are developing novel approaches for cell - type - specific analysis of neuropeptide signaling in the worm and the mouse.

We also have developed methods to visual cell type - specific de novo translation ex vivo in brain slices and in vivo in mice.

They were then transplanted into mice where they developed further into insulin - producing cells, curing the mice of type 1 diabetes.

For her dissertation, Prerana developed several bacTRAP transgenic mouse lines to characterize molecularly distinct cortical pyramidal cell types, and focused on layer 2/3 pyramidal cell population in the prefrontal cortex that moderate stress induced depression related behavior.

When transplanted into mice, the neural stem cells spontaneously developed into the three basic types of brain cells: neurons, oligodendrocytes, and astrocytes.

Wild type mice, such as the C57BL / 6 mouse, are relatively resistant to atherosclerosis, but have the capacity to develop mild atherosclerosis under certain conditions.

LaFerla, Mathew Blurton - Jones and Tritia Yamasaki performed their experiments using a new type of genetically engineered mouse that develops brain lesions in areas designated by the scientists.

-- NOD mice develop type 1 diabetes.

If the energy boost, delicious taste, and link to a longer life aren't enough for you, consider this: A new study conducted on mice found that substances in coffee can help reduce your risk of developing Type 2 diabetes.

The researchers did experiments with a type of lab mouse that easily puts on weight and develops diabetes [TSOD].

The mice given the Nobiletin flavonoid avoided these issues, while those that did not became obese, developed type 2 diabetes, and had atherosclerosis and fatty liver issues.

Duke University Medical Center researchers led by Kyle Allen found that collagen deficient mice prematurely developed common and chronic musculoskeletal disorders while the wild - type mice did not.