Sentences with phrase «type mice used»

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.

Not exact matches

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diet.

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

McCaffrey and his colleagues were trying to shut down the activity of a gene in living mice, using a completely new type of drug.

Hoping to develop a more potent approach, medical oncologist Ron Levy of Stanford University in Palo Alto, California, and colleagues used mice to test the cancer - fighting capabilities of some 20 molecules, including several types of antibodies that activate immune cells.

Different types of studies use different stand - ins: Flies for genetics; zebrafish for early development; rats and mice and monkeys for cancer, neuroscience and more.

In this study, the researchers used two groups of mice with different types of colitis, chronic and acute.

Hur added, «To investigate whether Cpf1 had off - target effects, we performed whole genome sequencing using genomic DNA isolated from one Foxn1 mutant mouse and its wild - type sibling.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver cells, which are more likely than other cell types to take up the AAV vector.

Researchers at Stanford University in Palo Alto, California, have used a type of gene therapy to treat mice with a disease that mimics multiple sclerosis (MS).

Researchers developed a new type of cell transplantation to treat mice mimicking a rare lung disease that one day could be used to treat this and other human lung diseases caused by dysfunctional immune cells.

To determine the most common type of age - related segregation errors, the researchers first used a novel high resolution imaging technique to visualize chromosomes in live mouse egg cells throughout the whole first stage of meiosis.

Next, the team used other mouse models in which part of the lung was removed and single cell culture to study the plasticity of cell types during lung regrowth.

It was used to immunize mice which were then infected by the wild - type Chikungunya virus.

Using juvenile and adolescent mice, Jeffrey Edwards and colleagues investigated the effects of tetrahydrocannabinol (THC), the chemical in marijuana responsible for its effects on cognition and behavior, on VTA GABA cells, an understudied inhibitory cell type in the reward system that regulates dopamine levels.

For prevention studies, they injected mouse α - syn synthetic preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).

Morgan Fullerton, lead author of the study, added: «Unlike the majority of studies using genetic mouse models, we haven't deleted an entire protein; we have only made a very minor genetic mutation, equivalent to what might be seen in humans, thus highlighting the very precise way metformin lowers blood sugar in Type 2 Diabetes»

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

They used genetic knockout mice to look for the cells, silencing different types of TRCs, then flushing the rodents» mouths with water to see which cells responded.

In the study, the scientists used a type of mouse, called CVN - AD, that they had created several years ago by swapping out a handful of important genes to make the animal's immune system more similar to a human's.

In addition, the researchers conducted an experiment in the Type I diabetic mice using modified insulin and nanoparticles that had been coated with red blood cell membranes.

Using genetic tools to activate these two neuron types with light, the scientists found that stimulating one neuron type caused mice to stop breathing completely, trapping them in a state of exhalation.

To determine whether normal food prompts mucosal immunity in the intestines, the research team generated a special type of mice, dubbed «antigen - free» mice that were not used in research since the 1980's.

BI-1206 showed remarkable success in mice in overcoming resistance to monoclonal antibodies like rituximab, currently used to treat different types of lymphoma and leukemia.

But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in other animals, and using other and less controversial types of cells — such as stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.

In total, the researchers identified 16 different types of FAHFAs in the mice using a technique called mass spectrometry.

Researchers at the University of Texas (U.T.) Southwestern Medical Center at Dallas noticed that mice used two primary methods to cope with defeat after being repeatedly pummeled by larger, more aggressive foes: Some of the weaker members withdrew, avoiding all types of social interaction for more than a month, whereas others rolled with the punches, so to speak, quickly bouncing back to their normal behavior.

But so far, silencing genes using RNAi has not worked well in mammalian cells; although the approach has been successful in mouse embryos, double - stranded RNA shuts down synthesis of all proteins, not just the target gene, in other types of mammalian cells.

Using mice bred to lack some types of lymphoid cells, among other features, researchers were able to show that those mice still had high levels of suPAR and proteinuria, indicating that lymphoid cells were not the perpetrators of kidney disease.

Crystal hopes to improve on his team's results by using a different type of viral vector that worked much better in mice in his latest studies.

The researchers also used advanced DNA analysis techniques that allowed them to detect the types and amounts of bacteria in mouse guts.

To verify these results, the researchers also used mice with APC deleted by traditional methods, and found the same types of tumors.

To determine whether treatment with Osteolectin could reverse bone loss after the onset of osteoporosis, the CRI research team used mice that had their ovaries removed to model the type of osteoporosis that develops in postmenopausal women.

The participants were asked to «point and click» on letters — similar to using a normal computer mouse — to type specific sentences, and their typing rate in words per minute was measured.

One of the common types that infect people, Salmonella Typhimurium, doesn't usually get mice sick, so Adkins and colleagues used mice uniquely sensitive to Salmonella infection.

C57BL / 6 wild - type mice (The Jackson Laboratory, 000664; n = 8) were used as an additional control for comparison purposes, but were not included in any statistical analyses.

Now we want to extend this technology to animal models, such as cancer bearing mice, to verify its practical use in different types of tumors,» explains Park.

To identify false - positives and estimate the type 1 error rate, we used the genomic positions of a set of known lineage - specific repeat families in human and mouse, since lineage - specific repeat insertions should not overlap ancestral elements.

It should be straightforward to apply the new library for use in various cell types and in live mice.

The present findings are derived from studies using CD4KO mice and thus, raise the question as to whether the CD4 + T cell - independent immune mechanisms in CD4 KO mice differ from those involved in corneal allograft rejection in wild - type mice whose CD4 + T cells population have been depleted with monoclonal antibodies.

Kissler and his research team are using a mouse model of type 1 diabetes to see what the genes do in a living animal.

In the current study, researchers used a mouse model of congenital elastin insufficiency — the rare condition of being born with abnormally low levels of elastin — to determine how minoxidil, a type of potassium channel opener, improves vascular health.

Working in mice, Norbury's team used several methods to deplete different types of innate immune cells — collectively known as myeloid cells — at the three checkpoints before infecting the rodents with poxvirus.

Using high - throughput DNA sequencing techniques, the research team looked at these functional elements in more than 1,000 data sets produced from over 100 mouse cell types and tissues.

Such techniques have the potential to enhance research into the origins of neurodevelopmental and neuropsychiatric disorders such as microcephaly, lissencephaly, autism and schizophrenia, which are thought to affect cell types not found in the mouse models that are often used to study such diseases.

Ng2 - Cre is known to be expressed in the male germline, which needs to be considered in using Ng2 - Cre mice for cell type - specific conditional mutagenesis experiments, but the germline expression of Pdgfrb - Cre in both sexes limits the use of Pdgfrb - Cre as deleter for pericyte - related experiments.

We have gone on to show that the sensitivity of the germ line genome instability differs across inbred strains of mice, offering a unique opportunity to use systems genetics approaches to discover the underlying pathways governing cell division and survival across a variety of cell types.

We exposed BALB / c mice to mutant strains and the wild - type strain in an aerosol challenge model using lethal B. mallei doses.