Sentences with phrase «type mouse liver»

Isolated wild - type mouse liver mitochondria efficiently imported those constructs that included the appended RP sequence, and cleaved their transcript terminus sequences in line with normal mRNA maturation.

Not exact matches

As a result, the intestinal wall becomes infected and inflamed, leaving the mice susceptible to conditions as diverse as inflammatory bowel diseases, colon cancer, Type 2 diabetes, obesity, and fatty liver disease.

The tumors in Sand's lab might be explained by the high dose, the fact that the mice were newborns, and the type of mouse, suggests Kay, who was involved with a past clinical trial administering AAV to the liver to treat hemophilia.

Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver cells, which are more likely than other cell types to take up the AAV vector.

In the new study, the researchers found that the offspring of pregnant mice that consumed a high - fat diet developed liver fibrosis, a type of tissue scarring that is a sign that more serious disease will develop.

However, chronic liver inflammation in both mice and humans also led to the accumulation of immunosuppressive lymphocytes, a type of immune cell Karin and Shalapour first described two years ago.

A cocktail of human cell types mixed in a dish (inset, left) spontaneously forms a three dimensional liver bud (inset, right) which is transplanted into a mouse for final development into a

Researchers at University of California San Diego School of Medicine have discovered evidence in mice and humans that stomach (gastric) acid suppression alters specific gut bacteria in a way that promotes liver injury and progression of three types of chronic liver disease.

These changes promoted liver inflammation and liver injury, increasing the progression of all three types of liver disease in the mice: alcohol - induced liver disease, NAFLD and NASH.

Compared with normal chow diet - fed mice, the high - fat diet mice showed worsened blood sugar, increased triglycerides, a type of fat (lipid) in the blood, and a substantial increase in the numbers of CD8 + T cells in the liver.

To test the effectiveness of the novel contrast agent, the team conducted imaging of mice livers to detect the spread of a type of melanoma.

Acute alcohol - treated FOXO3 - deficient mice developed more severe liver injury than that of wild - type mice, and this was attributed to decreased expression of autophagy - related genes.

The scientists note that certain specialized types of cells in the liver could also have limited virus reproduction and put a damper on systemic inflammation and blood clotting problems in resistant mice.

Further experiments identified new therapeutic options: Mice that are unable to produce Type - 1 interferon were protected against Listeria infection despite the migration of the gut bacteria into the liver, because their immune cells didn't produce high levels of Type - 1 interferon and IL - 10 after Listeria infection.

THS has been shown, in mice, to cause type 2 diabetes, hyperactivity, liver and lung damage, and wound - healing complications.

Differential response of the liver to bile acid treatment in a mouse model of Niemann - Pick disease type C

While scientists have successfully reprogrammed different types of mouse cells (fibroblasts, liver and intestinal cells), skin fibroblasts were the only human cell type they had ever tried their hands on.

By studying the stem cells in two types of tissue, namely skin, muscle, and in liver, in young (three months old) and aged (18 to 22 months old) mice every four hours, «we observed that the core components of the circadian clock had no changes in their rhythm with age».

The mice given the Nobiletin flavonoid avoided these issues, while those that did not became obese, developed type 2 diabetes, and had atherosclerosis and fatty liver issues.