Sentences with phrase «type mouse model»

Not exact matches

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diet.

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

A new mouse model of a genetically - linked type of autism reveals more about the role of genes in the disorder and the underlying brain changes associated with autism's social and learning problems.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

Sinclair thinks that these mouse models indicate that resveratrol may be effective in preventing age - related diseases in humans, like cancer, heart disease and type 2 diabetes.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

«It's very difficult to produce a mouse model of a solid tumor of the type we see in most women who are diagnosed with cervical cancer.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

The latest findings build on previous work by Dr. Habib's lab showing that the same combination of drugs was successful in a mouse model of glioblastoma, a deadly type of brain cancer.

In a paper published in Nature Immunology in 2011, Dr. Rostami and colleagues showed that the Th - 17 cells also produced another cytokine called GM - CSF, which created a chain reaction with another cell type ultimately increasing the GM - CSF levels in the brain of mouse models significantly.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

The patch, which feels like a mosquito bite when applied, has already proved effective in mouse models with type 1 diabetes for up to 9 hours, scientists report online before print in the Proceedings of the National Academy of Sciences.

The research of different types of cancer and the testing of new treatments depends on accurate mouse models.

Studies in mouse models suggest that BL - 9020 can inhibit beta cell death in the pancreas, thus preventing full maturation of Type 1 diabetes.

- like cells, which produce insulin, to partially rescue a mouse model of type 1 diabetes.

The next steps will be to test these combinations in more human cancer cell types and eventually in mouse models.

The team showed in mouse models that these two types of cells originate from a common precursor stem cell in the embryo.

Next, the team used other mouse models in which part of the lung was removed and single cell culture to study the plasticity of cell types during lung regrowth.

Morgan Fullerton, lead author of the study, added: «Unlike the majority of studies using genetic mouse models, we haven't deleted an entire protein; we have only made a very minor genetic mutation, equivalent to what might be seen in humans, thus highlighting the very precise way metformin lowers blood sugar in Type 2 Diabetes»

An important caveat is that the new research was conducted in a single type of mouse model of Alzheimer's.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

«In the study we found that the nerve cells in the mouse models of Alzheimer face a type of metabolic stress.

Because the anticancer compound works by binding to troublesome expansions in DNA, the researchers decided to test whether it would work in cells and a mouse model of myotonic dystrophy type 1.

Eliette Touati, joint last author of the paper and a scientist at the Institut Pasteur, adds: «We have observed in a mouse model that this type of damage is associated with a worsening of gastric lesions.

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

The combination was significantly toxic to pancreatic cancer cells and disrupted tumor growth and extended survival in several types of advanced pancreatic cancer mouse models.

In a mouse model of type 1 diabetes, RGS1 affects the population of one type of T cell called a «T follicular helper cell» that is critical for B cells and antibody production, Dr. Kissler and his colleagues reported recently in Genes and Immunity.

They examined behaviors of the following types of mice: normal mice, AS model mice, mice that had reduced levels of the Na / K - ATPase, and AS model mice in which expression of the subunit of Na / K - ATPase was reduced.

Tests on mouse models for type 1 diabetes show that one injection works for a minimum of 14 hours, during which time it can repeatedly and automatically lower blood sugar levels after mice are given amounts of sugar comparable to what they would consume at mealtime.

To determine whether treatment with Osteolectin could reverse bone loss after the onset of osteoporosis, the CRI research team used mice that had their ovaries removed to model the type of osteoporosis that develops in postmenopausal women.

They targeted two cell types in a mouse model for Parkinson's disease: PV - GPe neurons and Lhx6 - GPe neurons.

Now we want to extend this technology to animal models, such as cancer bearing mice, to verify its practical use in different types of tumors,» explains Park.

In the laboratory arm of the Joslin study, researchers studied a mouse model of human type 1 diabetes.

In their new paper in Journal of Immunology, Mandy Ford, Craig Coopersmith and colleagues show that 2B4 levels are increased on certain types of T cells (CD4 + memory cells) in human sepsis patients and in a mouse model of sepsis called CLP (cecal ligation + puncture).

In the present study, the scientists created a genetically mutant mouse model deficient in type 1A BMP - receptor (BMPR1A), a key receptor for BMP - 7 which has been shown to be associated with obesity in human populations.

In mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new host.

Kissler and his research team are using a mouse model of type 1 diabetes to see what the genes do in a living animal.

We are currently profiling inhibitory interneuron cell types in mouse models of AD to identify potential molecular mechanisms of interneuron dysfunction and potential targets of intervention.

Traditionally, this type of research would be conducted in animal models, most often mice.

In the current study, researchers used a mouse model of congenital elastin insufficiency — the rare condition of being born with abnormally low levels of elastin — to determine how minoxidil, a type of potassium channel opener, improves vascular health.

Up - regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimer's disease.

In academia, researchers often create the mice as live mammalian models of whatever type of cancer they are studying.

For example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic disease models (for example in mouse) by mapping to human or other systems.

In the Joslin study, scientists first examined gene expression in the hypothalamus of a mouse model of insulin - deficient (type 1) diabetes.

Such techniques have the potential to enhance research into the origins of neurodevelopmental and neuropsychiatric disorders such as microcephaly, lissencephaly, autism and schizophrenia, which are thought to affect cell types not found in the mouse models that are often used to study such diseases.

Differential response of the liver to bile acid treatment in a mouse model of Niemann - Pick disease type C

With the help of conditional and function - selective knockout mice for the glucocorticoid receptor (GR) the lab identified critical cell types and novel mechanisms for anti-inflammatory activities of glucocorticoids in different inflammatory disease models.

We exposed BALB / c mice to mutant strains and the wild - type strain in an aerosol challenge model using lethal B. mallei doses.

Using her mouse model, Stromnes watched as pancreatic tumors developed and noticed that one type of regulatory immune cell stood out.