Sentences with phrase «type of amyloid»

«It could also be used to identify new types of amyloids and presymptomatic patients who are at risk of developing the disease,» says Hammarström and collaborator professor Peter Nilsson.

Another limitation of this study is that the method the scientists used to detect the amyloid beta has not been thoroughly tested for detecting the types of amyloid beta present in the brains of healthy people.

PURPOSE: We had previously reported that certain of our murine (m) antihuman light chain monoclonal antibodies (mAbs) recognized an epitope common to AL and other types of amyloid fibrils.

These reagents, prepared against human light chain - related fibrils, recognize an epitope common to the beta - pleated structure of AL and other types of amyloid proteins and can effect rapid amyloidolysis when administered to mice injected with human AL amyloid extracts.

Not exact matches

It offers cardio protection, it helps lower bad cholesterol, it may help prevent the progression of multiple sclerosis, it has the ability to regenerate brain cells after a stroke, it has the ability to cross the blood - brain barrier to potentially ward off Alzheimer's disease, apparently it's good at wiping amyloid plaque from the brain (which studies haves linked to Alzheimer's), it may help to prevent certain types of cancer, and studies have shown that it inhibits cancer cell growth and metastases (meaning it keeps cancer from spreading).

There are new types of tools that can be used to allow doctors to view the amyloid plaque while a person is still alive and see the interactions that are taking place.

«None of the neurotrophic factor manipulations influenced amyloid deposition, while they all had effects on memory function, also in wild - type mice without amyloid beta pathology,» says Susanna Kemppainen, MSc, who presented the results in her doctoral thesis.

«This study has allowed us to sort out, in mice, which effects of the different types of APOE were most important to variation in amyloid plaque deposition,» says Eloise Hudry, PhD, of MGH - MIND, lead author of the Science Translational Medicine report.

People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin - producing pancreatic beta cells.

The study also confirmed similarities between Type 2 diabetes and Alzheimer's and other neurodegenerative diseases that are marked by an accumulation of toxic forms of amyloid proteins, she said.

But researchers in Italy and the United Kingdom reported in April that many different types of normal proteins — with no known link to diseases — can also fold into shapes indistinguishable from the dreaded amyloid fibrils.

Both types of dementia (memory and language) can be caused by an accumulation of beta - amyloid, an abnormal toxic protein in the brain.

Ambrosia also reported a 20 per cent fall in the level of amyloids — a type of protein that forms sticky plaques in the brains of people with Alzheimer's disease.

The team developed the test by comparing ratios of beta - amyloid types in 41 people's blood — some of whom had Alzheimer's — with PET scans showing how much beta - amyloid had aggregated in their brains.

Until now, scientists haven't thought this build - up was important to the disease process because it looked different from the types of protein accumulations — such as tau, amyloid and alpha synuclein — that are clearly toxic and always found in patients with Alzheimer's, Parkinson's and some forms of dementia.

Other researchers later showed that the brains of men with CTE had a second type of protein deposit called amyloid, another hallmark of Alzheimer's.

Type 2 diabetes (T2D) mellitus is characterized by hyperglycemia, insulin resistance, defective insulin secretion, loss of β cell function and mass, and accumulation of amyloid in the islets of Langerhans (Stumvoll et al., 2005).

C. elegans expressing a modified form of human amyloid - β survived three or four more days following infection in the gut with Candida albicans, compared to wild - type worms that did not express the peptide.

Such scans could help researchers determine if people with type 2 diabetes have elevated amounts of amyloid which may contribute to their increased risk for Alzheimer's disease.

Young mice that expressed high levels of human amyloid - β (but did not have pathological plaques) infected in the brain with Salmonella typhimurium were more likely to survive the infection compared to wild - type mice that did not express the peptide, Tanzi, Moir, and their colleagues found.

These «clinical trials in a dish» have advanced the search for treatments for inherited conditions, such as Huntington's disease, Parkinson's disease, amyloid lateral sclerosis, and types of cardiovascular disease.

NPT088 utilizes NeuroPhage's novel and proprietary GAIM (General Amyloid Interaction Motif) technology to simultaneously target multiple types of misfolded proteins found in many diseases of aging, including Alzheimer's and Parkinson's diseases, as well as peripheral diseases, including the systemic amyloidoses.

The 37 - amino - acid polypeptide amylin is the principal constituent of the amyloid deposits that form in the islets of Langerhans in patients with type - 2 diabetes mellitus, but its role in the pathogenesis of this disease is unresolved.

Four of the mAbs, 2T5C9, 2G9C, T1F11, and TB2H7, demonstrated diagnostic potential in enzyme - linked immunosorbent assays (ELISA) by their low to sub-nanomolar cross-reactivity with recombinant wild - type (WT) and mutant TTR aggregates and lack of binding to native TTR or amyloid fibrils formed by other peptides or proteins.

Demonstration of the therapeutic efficacy of this amyloid - reactive mAb would provide an important proof - of - principle that this form of immunotherapy also could benefit individuals with other types of inherited or acquired amyloid - associated disease.

Pancreatic islet amyloid, formed from islet amyloid polypeptide, is found in 96 % of Type II (non-insulin-dependent) diabetic patients.

Sup35 is a prion — a type of protein that can form tangled clumps known as amyloids.

Besides, AD researchers are still unsure whether eliminating beta - amyloid deposits (by any type of intervention) is the key to treating or stopping Alzheimer's.»

We can hope that as the first effective therapies make it into the clinic, most likely for the clearance of forms of amyloid, there will be a growing enthusiasm for work on ways to remove other types of metabolic waste.

SAN FRANCISCO, CA — Scientists from the Gladstone Institute of Neurological Disease (GIND), UCSF, and Stanford have discovered that a certain type of collagen, collagen VI, protects brain cells against amyloid - beta (Aβ) proteins, which are widely thought to cause Alzheimer's disease.

Beta - amyloid has been proven to be a definitive indicator of the early onset of Alzheimer's disease, which means that sleep deprivation is preventing the brain from removing this type of compound.

In animal studies it seems that it may affect levels of cholesterol, which may serve as a potential modulator of Alzheimer - type amyloid formation.

They then added either an active type of the omega - 3 fatty acid DHA known as resolvin D1 or an active type of vitamin D3 known as 1alpha,25 - dihydroxyvitamin D3 to a few of the cells to evaluate the effect that they had on amyloid - beta absorption and inflammation.

The researchers were looking for two specific types of protein: deposits of beta - amyloid plaque and knotted threads of tau protein tangles.

At the same time, curcumin binds to amyloid proteins, a type of improperly-folded protein whose excessive accumulation is linked to neurodegenerative disorders.

One study presented by Dr. Donald Weaver, from the Krembil Research Institute of the University of Toronto, found that an extract of maple syrup may help prevent the misfolding and clumping of two types of proteins found in brain cells - beta amyloid and tau peptide.

OTHER TYPES OF AMYLOIDOSIS include localized amyloid, b2 micro globulin amyloid, and Alzheimer's disease.