Sentences with phrase «type of estrogen receptor»

Sometimes they increase estrogenic activity — depending on the type of estrogen receptor present in this kind of tissue, say, in this case, the skin — and sometimes they increase it, like in the ovaries.

The researchers are collaborating with investigators at the University of Pennsylvania that have found that turning on a very specific type of estrogen receptor on melanoma makes it vulnerable to immunotherapy.

Not exact matches

A second type is a point mutation in the part of the receptor that binds estrogen, causing the receptor to become active even without estrogen.

Researchers at the Icahn School of Medicine at Mount Sinai have identified a protein that can be targeted to suppress growth of a common type of breast cancer known as «estrogen receptor positive» (ER +), including ER + cancers that are resistant to standard treatments.

And the third type is a translocation, in which half of the estrogen receptor gene is swapped for a completely unrelated gene from a different part of the genome.

«And we found all three types of «gain - of - function» mutations in the estrogen receptor gene ESR1 in the tumor samples.»

Perhaps shedding light on this mystery, the researchers found three different types of mutations in the estrogen receptor in patients whose cancer was resistant to anti-hormone therapy.

Currently, there are no molecularly targeted therapies aimed at triple - negative breast cancer, which is a type of cancer negative for estrogen receptor, progesterone receptor and the HER2 protein — all key targets for current therapies.

TNBC is deadly because, unlike other types of breast cancers such as estrogen receptor (ER) positive or HER2 amplified breast tumours which have effective targeted therapy, TNBC tumours do not respond to targeted therapy.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

Triple - negative breast cancer (TNBC), a tumor type defined by its lack of estrogen receptor, progesterone receptor, and Her2 (ERBB2) amplification, accounts for 16 % of breast cancers.

«The treatment for breast cancer is currently dependent on the type of breast cancer, defined by the estrogen receptor, progesterone receptor, and HER2 status.

Triple negative breast cancer is a type of breast cancer that does not express receptors for the hormones estrogen and progesterone, or for human epidermal growth factor.

«We found a strong reduction in the risk of estrogen - receptor - negative [ER --RSB- breast cancer in particular, which is exciting because that type of tumor, while rarer than estrogen - receptor - positive [ER +] tumors, tends to be aggressive.»

Two types of anti-estrogen drugs Tamoxifen (Nolvadex) and raloxifene (Evista) are part of a drug class called selective estrogen receptor modulators (SERMs).

A xenoestrogens will be recognized by the body as an estrogen, and it will attach to the same receptors as estrogen, like a key fitting one type of lock.