In the newly published study, Mount Sinai researchers from The Mindich Child Health and Development Institute and the Jaffe Food Allergy Institute report that by counting the numbers of one
type of immune cell activated by exposure to a food, a simple, safe blood test can accurately predict the severity of each person's allergic reaction to it.
When the team compared
the types of immune cells activated in the fetus with those in the mother, there were clear differences, suggesting that fetuses generate an independent immune response to CMV (Journal of Experimental Medicine, DOI: 10.1084 / jem.20090348).
Not exact matches
By administering a complementary antibody, they blocked the function
of two such
immune checkpoints, whereby different
types of endogenous T -
cells were
activated.
Without the regulatory influence
of PD - 1, the over
activated and over stimulated T
cells result in disruption
of a crucial balance between different T
cell types that leads to an overall greatly reduced
immune response.
One advantage
of this method is that it only
activates a certain
type of immune cell, the dendritic
cell or T -
cell, and only in one part
of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.
Hoping to develop a more potent approach, medical oncologist Ron Levy
of Stanford University in Palo Alto, California, and colleagues used mice to test the cancer - fighting capabilities
of some 20 molecules, including several
types of antibodies that
activate immune cells.
THC
activated two
types of cannabinoid receptor on
immune cells, called CB1 and CB2.
The researchers studied two
types of cells called effector T
cells, which
activate the
immune system to defend our body against different pathogens, and regulatory T
cells, which help control the
immune system and prevent it from attacking healthy parts
of its environment.
Current thinking regarding
type III hypersensitivity is that
immune cells within tissues sense the presence
of these
immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that
activate the endothelial
cells lining adjacent blood vessels to promote the recruitment
of neutrophils.
Coussens and her U.C.S.F. colleagues Douglas Hanahan and Zena Werb reported in 1999 that mice engineered with
activated cancer genes but without mast
cells (another
type of innate
immune cell) developed premalignant tissue that did not progress to full malignancy.
A few years ago, Chawla's group had reported that cold exposure
activated macrophages, a
type of immune cell, in white adipose tissue.
Two teams
of scientists suggest that
activating immune cells in fat can convert the tissue from a
type of fat that stores energy to one that burns it, opening up potential new therapies for obesity and diabetes.
Moffitt researchers wanted to determine if it would be possible to
activate the cancer - fighting properties
of T
cells indirectly by targeting another
type of immune cell called a dendritic
cell.
Once the intruder has been bound by the BCR, the B
cell is
activated and, together with other
immune cells, can fight off a range
of different
types of pathogens.
Older studies have shown that certain compounds can
activate iNKT
cells in mice by stimulating the response
of another
type of immune cell called cytokines.
Her aim is to understand, at the molecular level, the mechanisms that control communication between the brain,
immune system, and blood vessels — with the ultimate goal
of designing new therapies that slow, stop, or reverse the progression
of a wide range
of neurological disorders, such as MS. Recently, Dr. Akassoglou's lab identified how microglia — a
type of immune cell that acts as the brain's first line
of defense — are
activated when fibrinogen enters the brain or spinal cord.
Until now, however, achieving a similar feat in human
cells has eluded scientists — partly because
activating iNKT
cells released different
types of cytokines: some stimulated an
immune response, while others inhibited it.
In doing so, specific
cell types may
activate immune responses to fine tune
cell - fate decisions at the organismal level; for instance, DNA damage in germ
cells induces an innate
immune response in worms that promotes endurance
of somatic tissues to allow delay
of progeny production when germ
cells are hit by DNA damage.
For decades, scientists have been seeking a new
type of vaccine that
activates another player in the
immune system called a T
cell to fight off infections within different organs.
Reishi has been shown to
activate several
types of human
immune cells such as macrophages and natural killer
cells.
ACT -
activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT -
activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band
cell —
type of white blood
cell Baso basophil —
type of white blood
cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating
cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood
cell antibody test (
immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil —
type of white blood
cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake
of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver,
immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup
of white blood
cells Hb, Hgb hemoglobin — iron rich protein bound to red blood
cells that carries oxygen (anemia, red
cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed -
cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte —
type of white blood
cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red
cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed -
cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part
of the C&S that determines antimicrobial selection Mono monocyte —
type of white blood
cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood
cell — immature red blood
cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed -
cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet —
cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood
cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood
cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil —
type of white blood
cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood
cell count (infection, inflammation, bone marrow suppression)