Not exact matches
Instead, after several days, researchers harvest embryonic
stem cells, which theoretically can develop
into any
type of cell and, according to many researchers, may someday be used to treat neurodegenerative diseases or other conditions.
The researchers dialed the skin
cells back, developmentally speaking, to produce induced pluripotent
stem cells (iPSCs)-- a special
type of cell that can both self - renew, making more iPSCs, and differentiate, specializing
into almost any other
cell type.
To develop their «disease in a dish» model, the team took skin
cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them
into induced pluripotent
stem cells, which then can be developed
into any
type of tissue in the body.
Because they can differentiate
into almost any
cell type in the body,
stem cells have the potential to be used to create healthy
cells to treat a number
of diseases.
Neuronal
stem cells are marked by their ability to differentiate
into other
types of cells.
Further ahead, he is looking to an emerging technology known as induced pluripotent
stem cells (iPSCs), in which adult
cells are reprogrammed to be like embryonic
stem cells so they can transform
into any
type of cell.
Bioengineers at the University
of California, San Diego have proven that when it comes to guiding
stem cells into a specific
cell type, the stiffness
of the extracellular matrix used to culture them really does matter.
The project's goals were to explore and describe the range
of epigenetic changes that take place in bone marrow as
stem cells develop
into different
types of mature blood
cell.
Slight modifications in their genome sequences play a crucial role in the conversion
of pluripotent
stem cells into various differentiated
cell types.
As the heart starts pumping a primitive blood - like fluid around the body
of an embryo, the change in pressure from the flowing liquid is the cue for
cells lining the aorta to change first
into blood
stem cells, then
into all blood -
cell types in the body.
The molecules — called SMAD2 and SMAD3 — can enhance the efficiency
of converting mature
cells into induced pluripotent
stem cells, which have the distinctive ability to become any
type of cell found in the body.
Some
of the researchers at the centre will study the differentiation
of stem cells into other
cell types, one group by using human embryonic
stem cell biology and another by studying early embryo development.
The researchers also found that arteries and veins from the macaques» hearts grew
into the new heart tissue, the first time it has been shown that blood vessels from a host animal will grow
into and nurture a large
stem -
cell derived graft
of this
type.
«Just as normal
cells with the same genome differentiate
into many different
cell types, a single tumor characterized by specific genetic mutations can contain many different
types of cells —
stem - like and more differentiated
cells — with the difference being rooted in their epigenetic information.
This summer Wagers published research [subscription required] showing that when muscle
stem cells were transferred
into mice with a
type of muscular dystrophy, the rodents» muscle function improved.
Other adult
stems cells exist — such as hematopoietic
stem cells, which can generate all
types of blood
cell and mesenchymal
stem cells, which can turn
into bone, fat and cartilage
cells.
Wells's team first turned human skin
cells into pluripotent
stem cells, which can grow
into any
type of tissue.
But getting pluripotent
stem cells to differentiate
into a particular
type of cell that can function inside the body is not simple.
Progenitor
cells are early descendants
of stem cells that can differentiate
into one or more specific
cell types.
«Disturbances to these processes may cause neuronal
stem cells to develop
into different
types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»
Badylak soon suspected that the recruits were
stem cells, the all - purpose
cells that can develop
into any
type of tissue.
They then tried to reprogram skin
cells from the animals, turning them
into induced pluripotent
stem cells (iPS), which are capable
of forming other
types of cell.
► The U.S. National Institutes
of Health (NIH) has put funding on hold for experiments that involve «mixing human
stem cells into very early animal embryos and letting them develop» while it «reconsiders its rules» for this
type of research, Gretchen Vogel reported Wednesday.
They then encouraged the
stem cells to grow
into neurons, a
type of brain
cell.
The Karlssons were referred to the Karolinska University Hospital in Stockholm, where physicians proposed a radical strategy: Harvest a specific
type of stem cell from the liver
of an aborted fetus and infuse it through the umbilical vein
into the fetus that Madeleine was carrying.
These so - called pluripotent
stem cells can be derived from a variety
of adult
cells and be guided
into almost any other tissue
type.
First produced only in the past decade, human induced pluripotent
stem cells (iPSCs) are capable
of developing
into many or even all human
cell types.
Stem cells have the prized ability to divide and replenish themselves, as well as turn
into different
types of tissues.
One
of the many mysteries
of stem cells is how they morph from a universal
cell type, full
of possibility,
into one that's tailored for a specific job.
By turning on a several genes in adult
cells, scientists can transform skin or blood
cells into stem cells that can become every
cell type in the body — without the ethical and practical complications
of using embryos or oocytes.
The blood ancestors are usually called hematopoietic
stem cells; these
cells were classically defined as a specific category
of multipotent
cells at the top
of the hierarchy that can differentiate
into any blood
cell type by following a deterministic program.
Semenza says methylation leads to the destruction
of NANOG's mRNA so that no protein is made, which in turn causes the embryonic
stem cells to abandon their
stem cell state and mature
into different
cell types.
Johns Hopkins researchers have developed a method to efficiently turn human
stem cells into retinal ganglion
cells, the
type of nerve
cells located within the retina that transmit visual signals from the eye to the brain.
Looking further
into the intestinal crypts
of both the transgenic and wild -
type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the
stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number
of Paneth
cells, a
type of niche
cell known to support intestinal
stem cells.
Researchers also plan to modify the genetic set up
of induced pluripotent
stem cells (iPS), which can be differentiated
into specialized
cell types or tissues.
What he instead plans to do is turn the iPSCs
into blood - forming
stem cells, which when transplanted
into the body would give rise to all
of the
cell types found in the blood.
Although primed, post-implantation embryonic
stem cells can still turn
into any
type of human
cell, they are more difficult to work with than the pre-implantation, naive
cells.
Embryonic
stem cells: They can turn
into any
of the body's 220 different
cell types, meaning they are pluripotent.
In Arabidopsis, as in most plants, there is a specific zone near the tip
of the root where
stem cells transition from a stage
of proliferation to one where they differentiate
into specific tissue
types.
One
of the reasons pluripotent
stem cells are so popular in medical research is that they can be differentiated
into any
cell type.
Since embryonic
stem cells can differentiate
into any
type of tissue, they have the potential to treat an almost unending array
of medical conditions — replacing damaged or lost body parts or tissues, slowing degenerative diseases, even growing new organs.
Adult
stem cells: They have less flexibility and «stemness» to change
into different
cell types, but they can still produce new
cells, specialized to become part
of a particular organ or tissue, such as muscle
cells or neural
cells.
This ball
of cells contains «pluripotent
stem cells» — blank slates that can be programed
into any
type of cell in the body — and researchers are hoping to use these
stem cells to treat various conditions, including infertility.
In the last few years, researchers have learned how to turn embryonic
stem cells into all sorts
of different
cell types, such as skin
cells, heart
The skin's ability to grow back after a wound led scientists to assume that it must contain
stem cells, immature
cells that can rapidly differentiate
into many different
types of tissue.
«Because
of the Harvard
Stem Cell Institute, we were able to work with other researchers to make patient
cells into any
type of neuron,» said Young - Pearse, whose lab spent two years fine - tuning protocols with collaborators to generate the neurons needed for her early onset Alzheimer's study.
The researchers traced
stem cells as they matured
into motor neurons, which are the
type of nerve
cells that control muscle movement.
These
stem cells — known as induced pluripotent
stem cells or iPS
cells — can be turned
into almost any specialised
cell type of the human body, including the
cells we need to see.
Stem cells have two important capabilities: they can develop into a wide range of cell types and simultaneously renew themselves, creating fresh stem ce
Stem cells have two important capabilities: they can develop
into a wide range
of cell types and simultaneously renew themselves, creating fresh
stem ce
stem cells.
«Use
of induced pluripotent
stem cell (iPSC) technology» — which involves taking skin
cells from patients and reprogramming them
into embryonic - like
stem cells capable
of turning
into other specific
cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie
of KU Leuven.