Sentences with phrase «type of tumor into»

A network of transcription factors may drive different subtypes of aggressive bladder cancer, allowing researchers to turn one type of tumor into another

Not exact matches

In 2009 he had been diagnosed with a type of rapidly growing brain tumor called a high - grade astrocytoma that, despite aggressive treatment, eventually evolved into a glioblastoma — the highly malignant brain tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.

«The traditional way to deliver drugs to tumors is to put the drug inside some type of nanoparticle and inject those particles into the bloodstream,» said Jian Yang, professor of biomedical engineering, Penn State.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

With the approval of the local ethics committee, a 16 - year - old boy with a rare type of liver cancer called fibrolamellar hepatocellular carcinoma was given infusions of 3BP into the blood vessels supplying the tumor, formulated in a proprietary and patented fashion.

A common feature of cancer across many tumor types is that patients fall back into the state of illness after apparent recovery.

For each patient, the suitable combination treatment could then be designed, which, in the first step, would turn the variety of different tumor cells into a mass of cancer cells of the same type.

«These results provide an unprecedented window into the cellular dynamics of tumor evolution and suggest that interactions between subpopulations of tumor cell types contribute to metastatic progression from initial tumors,» Stanger said.

Apart from the tumor type, the choice of treatment sometimes has to take into account implications for the woman's fertility.

A major challenge in creating any type of organoid is determining the unique mixture of nutrients, growth factors, and tissue culture techniques that will transform patient tumor cells into miniature tumor organoids in a petri dish.

BETs have been fast - tracked into clinical trials and have shown impressive slowing of tumor growth in multiple cancer types.

They also showed that drugs against a type of breast tumor called HER2 positive breast cancer — such as the dual ERBB2 / EGFR inhibitor lapatinib — potentially could benefit more patients than currently receive them, if analysis of the tumor proteins is taken into consideration.

«The apparent ability to change immunosuppressive T cells within the tumor into T cell types that are more active and potentially helpful against cancer was a really exciting finding, and one that we're continuing to investigate,» says Poznansky, who is an associate professor of Medicine at Harvard Medical School (HMS).

Injected into rodents, the cells don't form tumors; rather, they migrate through the animals» brains, where they differentiate into various types of neural cells including the cells that create the myelin that protects nerve fibers.

The important next step for the field, Cibelli says, is to find reliable ways to differentiate the cells into a variety of useful cell types and to be sure that no undifferentiated cells remain to cause potential tumors.

«We also need to integrate PIK3CA mutation analysis of breast tumors into routine practice so that we can ensure women receive the most appropriate neoadjuvant therapy for their tumor type.»

The tumor cells were all undifferentiated and hence provided a homogeneous peripheral field, in contrast to the cells of the normal limb bud, which were destined to differentiate into many types of tissue.

Bethesda, Md., Wed., May 1, 2013 - A comprehensive genomic analysis of nearly 400 endometrial tumors suggests that certain molecular characteristics - such as the frequency of mutations - could complement current pathology methods and help distinguish between principal types of endometrial tumors, as well as provide insights into potential treatment strategies.

In the same opening plenary session, George Coukos, M.D, Ph.D., of Ludwig Cancer Research and the University Hospital of Lausanne, discussed some cutting - edge insights into ovarian cancer, a tumor type that's typically resistant to immunotherapy.

Transplanting non-cardiac stem cells also increases the risk for tumor formation, as many of the cells turn into other cell types besides the target heart cells.

These cells are cancerous yet have properties of stem cells: self - renewal and the ability to differentiate into multiple cell types that occurs in tumors.

Yoon says the presence of these cells could be a marker for tumor growth and metastasis. Because tumors often metastasize along lymph ducts and into lymph nodes, studying this type of cells could lead to new targets for blocking tumor metastasis.

«Using single - cell signatures, colorectal cancers can be further divided into subgroups based on cell - type composition of tumors,» JAX research scientist and paper co-author Elise Courtois, said in a statement.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

Interestingly, when parental d42m1 sarcoma cells were transplanted into wild - type mice, around 20 % of recipients developed «escape» tumors which evaded immune destruction and progressed (escape clones).

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Determining the optimal treatment plan takes a number of factors into consideration, including the patient's preferences, the type, number, location and aggressiveness of the tumor (s) as well as the overall health of the patient.

We identify and advance therapeutics into clinical trials for children with brain cancer, with increasing focus on types of brain tumors that are uncommon and have the greatest need for translational research.

In a study published recently in Cell, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the body).

Physicians who treat neuroblastoma must take many factors into account: location of the tumor, its size, whether or not the patient was treated with other therapies in the past and the type of therapies.

Pituitary tumors are a type of brain tumor that can often mimic the function of this gland, producing extra hormones that your body doesn't need (and throwing your other hormones into disarray).

Clinicians also conduct clinical research and three current, ongoing studies include investigations into canine osteosarcoma, the most common bone cancer in dogs; soft tissue sarcomas, the most common type of solid tumors in dogs; and feline fibrosarcoma, injection - site tumors in cats.

We don't know if this tumor will develop into something more serious, but the vet said that spayed female dogs are far less likely to have those types of tumors and thus, fewer cancers.

After irradiating the tumor, veterinarians collect a particular type of the dog's white blood cells, known as Natural Killer (NK) cells, then stimulate and grow the cells in a laboratory before injecting them back into the dog's tumor.

There are various types of bladder tumors like squamous cell carcinoma (arise in the epithelial cells), adenocarcinoma (arise in the glandular epithelium), undifferentiated carcinoma, rhabdomyosarcoma (tumor of the striated muscle - form of fibers combined into parallel fibers like the skeletal and the cardiac muscles), fibroma (tumors made of fibrous or connective tissue.

We will also perform needle aspirates, which is a form of biopsy where a needle is inserted into the tumor to collect cells for use in determining tumor type.