Sentences with phrase «types of allele»

In his paper, Mr Gellatly demonstrates that it is likely men carry two different types of allele, which results in three possible combinations in a gene that controls the ratio of X and Y sperm;

There are two types of alleles, called A and G. Among the people with at least one A allele, 80 % benefited from the drug, while only 62 % of those with 2 G alleles did well.

Not exact matches

Dr. Kshirod K. Jena, a principal scientist at IRRI whose research has been on breaking the yield barrier of rice using genomics strategy, and his team discovered that the gene Gn1a - type 3 allele had not been very effective in indica cultivars.

Finally, in a group of Hispanic children, the researchers found that the C allele (CT, CC types) was associated with a higher BMI score.

But human leukocyte antigens — a group of genes that encode proteins essential to the human immune system — in the samples showed that a few individuals had a type, or allele, found among only Native Americans.

As shown in Table 1, the presence of one or two Mstn mutant alleles in combination with the F66 transgene resulted in increasingly more muscle mass than seen in F66 transgenic mice that were wild type for Mstn.

In transient transgenic reporter studies of zebrafish embryos, the +254 kb element holds up: the wild - type allele had enhancer activity in 41/82 embryos (50 %), whereas the mutant allele had enhancer activity in 3/83 embryos (3.6 %).

Both experiments showed that the wild - type allele had greater DNA - binding capacity, and drove higher expression of the reporter gene.

By comparing gene expression changes induced upon expression of wild - type and mutant alleles, we inferred the activity of specific alleles.

By injecting pairs of TALEN - encoding mRNAs into wild - type embryos, we generated the CCHa2 - RTAL - 34 frameshift allele (Figs 3B and S2B and S2C).

Here, we identify three additional novel mutant alleles of the SHELL gene, which encode a type II MADS - box transcription factor, and determine oil yield via control of shell fruit form phenotype in a manner similar to two previously identified mutant SHELL alleles.

The latter work addresses questions including whether infection with different serotypes is associated with distinct types of T cell responses, whether any HLA alleles are associated with pathogenesis or protection, and whether vaccination with a formulation in clinical trials is associated with T cell responses similar to those following infection that might serve as correlates of protection.

Our objective is to generate a resource that facilitates research into human immune - related diseases by creating a comprehensive database of cell type - and allele - specific epigenomic and transcriptomic data for the immunology community.

HLA class II alleles and haplotypes in Icelandic Type I diabetic patients: comparison of Icelandic and Norwegian populations Diabetologia (Vol.

Given a file of read alignments, VarScan detects sequence variants, combines them by position and type, and then computes the read counts, average base quality, and number of strands supporting each allele.

In cfDNA isolated from plasma after treatment resistance, at a local read depth of 968x, 459 reads (44 %) bore the wild - type allele.

The location and frequency of the p.K1872X / wild - type allele are noted in gold / blue.

At a local read depth of 200x, 48 DNA reads (24 %) bore the p.K1872X allele, whereas 38 reads (19 %) bore the wild - type allele.

The number of distinct reads bearing each type of reversion allele ranged from 22 to 1, with deletion sizes ranging from 1 to 42 bp.

Using quantitative PCR, we compared the levels of Hex transcript from the wild - type and transgenic alleles to those from the transgenic allele only.

Espinasa, L., Centone, D. M., and Gross, J. B. (2014) A contemporary analysis of a loss - of - function of the oculocutaneous albinism type II (Oca2) allele within the Micos Astyanax cave fish population.

Alleles associated with lower levels of low density lipoprotein cholesterol (LDL - C) have recently been associated with an increased risk of type 2 diabetes (T2D), highlighting the complex relationship between LDL - C and diabetes.

After three days, they tested each cell in every embryo to learn how many had two copies of the wild - type allele.

The benefit seemed to be particularly pronounced in individuals with the apolipoprotein E-e4 allele, a genetic marker associated with late - onset Alzheimer's, which usually happens after the age of 65, and is the most common type of the disease

15 In fact, type 2 diabetes (T2D)-- a condition stemming from broken glucose metabolism and insulin signaling — has been identified as an additional risk factor for developing AD.16, 17 Moreover, the pathological changes that occur in AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factype 2 diabetes (T2D)-- a condition stemming from broken glucose metabolism and insulin signaling — has been identified as an additional risk factor for developing AD.16, 17 Moreover, the pathological changes that occur in AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key facType 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factor.

Although training may play a role in causing fiber type shifts, there is likely a large genetic component in the determination of fiber type (possibly including the ACTN3 R allele).

Vincent et al. (2007) took muscle biopsies from the vastus lateralis and reported that individuals with the R allele displayed a type I, type IIA and type IIX distribution of 50 ± 2 %, 37 ± 2 %, and 14 ± 2 %, while individuals with the XX allele displayed a type I, type IIA and type IIX distribution of 55 ± 3 %, 35 ± 2 %, and 9 ± 1 %.

Per Allele Association of a Sexually Dimorphic Instrument Testing if Waist - to - Hip Ratio Adjusted for Body Mass Index Associates With Type 2 Diabetes and / or Coronary Heart Disease

This provides a logical genetic indicator and explains why it is likely that certain dilute or patterned dogs, such as extreme piebalds, or other types of homozygous dilutes common in the APBT, as well as those that may be carrying the Merle pattern are prone to psychological, neurological and / or immunological problems found in other breeds that carry these alleles.

All the Labradoodles in the litter will have similar coat types (in this case, wavy and low shedding), the result of the combination of the different alleles of their two parents.

There is no direct test for the Wild type (think wolf pattern) allele which is designated aw.Any dog which has at least one copy of Ay (and no KB) will be fawn or sable, either with or without brindling.Any dog that is «aa» (and no KB) will be black.

Normally, capital letters are used to represent the most dominant of each series, and the subcase letters under them refer to progressively less - dominant (recessive) forms or alleles of each type of gene.

The minor allele of rs25532 significantly decreased luciferase reporter gene expression levels by 15 — 80 %, depending on 5 - HTTLPR allele background and cell type.

Although an interaction was established between the type of care (institutional vs. family) and genetic moderation factors, with a protective factor of the 5HTT / allele genotype for high scores on attachment disorganisation in institutionalized children, the authors noted that it is not clear if genetic factors can protect some children in adverse environments or if the experience of being raised in these environments can alter the expression of the gene.