One example is the generation of different
types of blood cells from their precursors, the hematopoietic stem cells.
Not exact matches
It offers cardio protection, it helps lower bad cholesterol, it may help prevent the progression
of multiple sclerosis, it has the ability to regenerate brain
cells after a stroke, it has the ability to cross the
blood - brain barrier to potentially ward off Alzheimer's disease, apparently it's good at wiping amyloid plaque
from the brain (which studies haves linked to Alzheimer's), it may help to prevent certain
types of cancer, and studies have shown that it inhibits cancer
cell growth and metastases (meaning it keeps cancer
from spreading).
If your baby's jaundice happens because he has a different
type from his mom, your doctor may need to give him a
blood protein through an IV that helps stop the breakdown
of red
blood cells.
As the heart starts pumping a primitive
blood - like fluid around the body
of an embryo, the change in pressure
from the flowing liquid is the cue for
cells lining the aorta to change first into
blood stem
cells, then into all
blood -
cell types in the body.
Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes
from liquid to gas, the Johns Hopkins researchers calculated the probability distribution
of methylation along the genome in several different human
cell types, including normal and cancerous colon, lung and liver
cells, as well as brain, skin,
blood and embryonic stem
cells.
Today in
Cell and associated journals, 24 research studies
from the landmark BLUEPRINT project and IHEC consortia reveal how variation in
blood cells» characteristics and numbers can affect a person's risk
of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, celiac disease and
type 1 diabetes.
The researchers also found that arteries and veins
from the macaques» hearts grew into the new heart tissue, the first time it has been shown that
blood vessels
from a host animal will grow into and nurture a large stem -
cell derived graft
of this
type.
Smider and colleagues took serum —
blood with the
cells removed, leaving antibodies behind —
from four immunized cows and tested it against different
types of HIV virus in a test tube.
In their latest study, they tested compounds against
cells from nine different
types of human cancer, including common
types affecting
blood, colon, breast, prostate, ovaries, kidneys, and lungs.
They demonstrated that PS extracts protect
blood and immune
cells from infection by HIV - 1, the most widespread
type of HIV.
It is the stuff
of dreams for flu scientists, but it could be within reach if a new
type of vaccine that elicits an immune response
from white
blood cells is combined with traditional vaccines.
The researchers then took naïve immune
cells — which transform into different
types based on the invaders they encounter —
from the
blood of healthy individuals and exposed them to bacteria in the guts
of MS patients.
[Chinedu Nwokoro et al., «Inhaled black carbon in the lower airways
of London cyclists»] Researchers at the London School
of Medicine collected sputum samples
from healthy non-smokers who walk or bike to see how much black carbon was in airway macrophages — a
type of white
blood cell that takes in foreign material.
Lymphoma is a
type of blood cancer that affects the white
blood cells — called lymphocytes — that help protect the body
from infection.
Luster's team hopes to further investigate the characteristics
of joints that underlie the critical role
of C5a in initiating
type III hypersensitivity and whether specific molecules expressed on endothelial
cells lining joints play a role in transporting C5a and chemokines
from the joint space into adjacent
blood vessels.
Living in overcrowded conditions appears to protect children and young adults against developing a particular
type of Hodgkin lymphoma (HL), a cancer that originates
from the lymphocytes (white
blood cells).
In
type 1 diabetes, the pancreas stops making insulin, the hormone that facilitates absorption
of glucose
from the
blood into
cells.
Earlier mouse studies by Li and his collaborators had indicated that the expression
of several imprinted genes changes as hematopoietic stem
cells embark on their journey
from quiescent reserve
cells to multi-lineage progenitor
cells, which form the many highly specialized
cell types that circulate within the
blood stream.
Copeland's team also noted that these mice suffered
from a host
of immune - related problems, the most crippling being a flood
of macrophages — a
type of white
blood cell — damaging the lungs and other organs.
An international team
of scientists, led by Monash Biomedicine Discovery Institute researcher Dr Di Yu, and Dr Axel Kallies
from the Walter and Eliza Hall Institute, have discovered that killer T
cells, a specialised
type of white
blood cells, can find these «hidden» infected
cells in tissue and destroy them.
«He identified a
type of molecular sensor, which programmed T
cells isolated
from human
blood with customized instructions for thwarting attack.
(Left)
Blood smears from anemic mice indicate irregular shapes of red blood cells; (right) wild type mice indicate normal shapes of red blood c
Blood smears
from anemic mice indicate irregular shapes
of red
blood cells; (right) wild type mice indicate normal shapes of red blood c
blood cells; (right) wild
type mice indicate normal shapes
of red
blood c
blood cells.
But that production stops after a meal, when insulin is released by the pancreas and performs its main task
of removing sugar
from the
blood and shepherding the glucose to multiple
types of cells that absorb it for energy.
After 3 months, the researchers drew
blood samples
from the monkeys, purified five different
types of immune
cells, and measured gene expression across their entire genomes.
CEPH's idea was to develop a reference panel
of large families, taking
blood samples
from each
of their members to build up a
cell bank for genetic
typing.
Adds Liu: «With metastatic cancers accounting for around 90 %
of deaths
from solid tumors, the hope is that one day a device that can enable the analysis
of single tumor
cells circulating in the
blood could make a big difference in early diagnosis, detection and monitoring
of numerous
types of cancer, without invasive biopsies.»
In order for these unspecialized
cells to acquire the characteristics that make a leaf
cell different
from a root
cell or a
blood cell different
from a muscle
cell, they must turn on different subsets
of genes to produce the proteins responsible for each
cell type's distinctive properties.
In the newly published study, Mount Sinai researchers
from The Mindich Child Health and Development Institute and the Jaffe Food Allergy Institute report that by counting the numbers
of one
type of immune
cell activated by exposure to a food, a simple, safe
blood test can accurately predict the severity
of each person's allergic reaction to it.
«Our group pioneered the development
of cell culture technology for harvesting large numbers
of stem
cells from human bone marrow and human umbilical cord
blood,» Dr. Yeh said, noting that stem
cells from these two sources are abundant and can be guided into different
types of cells using tissue engineering.
Although myeloma is, like leukemias and lymphomas, a cancer involving white
blood cells known as lymphocytes, myeloma
cells don't traditionally express CD19 on their surface because they arise
from the most mature
type of lymphocytes — plasma
cells.
Research
from the 1980s found that there are actually four
types of sickle red
blood cells, and not all
of them are rigid and sickle - shaped.
In general, founder
cells are easy to acquire
from a donor and come in one
of four
types: fibroblasts, keratinocytes, peripheral and umbilical cord
blood, and dental pulp
cells.
Haruko Obokata
of the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan, and colleagues at other Japanese institutions and at Harvard Medical School in Boston reported that simply subjecting
blood cells from newborn mice to a moderately acidic environment for 25 minutes and then tweaking culture conditions could generate pluripotent stem
cells capable
of developing into nearly all
of a body's
cell types.
Overall, including all genomic variations present in most if not all tumor
cells (clonal) as well as those present only in subsets
of the cancer
cells (subclonal)
from tumor tissue, the researchers detected a total
of 864 genetic changes in tissue samples across the three tumor
types, and 627 (73 %)
of those were also found in the
blood.
To create the repository, the researchers are taking
blood cells from Gulf War veterans and «reprogramming» them into their «pluripotent» state, which can then be transformed into any
type of cell,
from a kidney to a neuron.
Johannes Scheid, a student in Nussenzweig's lab, isolated it several years ago
from an HIV - infected patient whose immune system had an exceptional ability to neutralize HIV in the
blood by preventing the virus
from infecting and destroying a specific
type of immune
cells, called CD4
cells, in patients.
At that key point, Takebe added two more
types of cell known to help to recreate organ - like function in animals: endothelial
cells, which line
blood vessels, taken
from an umbilical cord; and mesenchymal
cells, which can differentiate into bone, cartilage or fat, taken
from bone marrow.
UH researchers have identified a unique epigenetic footprint in specific
types of immune
cells from blood that can identify individuals with HIV that have a range
of impairments in cognitive function.
Hungerford, a predoctoral fellow, was writing his doctoral thesis on chromosomes in a genetics lab at Fox Chase Cancer Center, and detected a tiny flaw in chromosomes
from the
blood cells of patients with a
type of leukemia.
Both
of the
cell types come originally
from the
blood and can be considered immune
cells.
And if it wasn't hard enough, I heard more reports
of somatic mosaicism (mutations present only in certain
cell or tissue
types) underlying disease susceptibility, meaning that DNA
from blood cells may not be informative in some patients for some diseases.
• Detect Zika virus in
blood and urine samples within hours and distinguish between its African and American strains • Distinguish between Zika and dengue • Discriminate different
types of bacteria, like E. coli • Detect cancer
cell mutations • Detect antibiotic resistance genes • Read human genetic information
from saliva sample
Role
of hematopoietic stem
cells in steady state hematopoiesis It is remain not very clear if all
blood cell types are developed
from one hematopoietic stem
cell (HSC) in normal hematopoiesis, because
of limitations
of conventional transplantation models.
Plasma
cells develop
from B lymphocytes (B
cells), a
type of white
blood cell that is made in the bone marrow.
The study seeks to establish induced microglia - like
cells (iMGCs)
from monocytes, another
type of white
blood cell, and validate iMGCs through their signature and function.
Unlike embryonic stem
cells from earlier in development, fetal stem
cells from umbilical cord
blood are multipotent - they can develop into a limited number
of cell types.
Examining the genomic and epigenetic makeup
of major
types of immune
cells from nearly 200
blood donors in the U.K., IHEC researchers found that genetics explain most
of the epigenetic variation among individuals.
The team analyzed the frequency
of different
types of immune
cells in
blood collected
from 110 one year - old study participants, the presence
of immune - stimulatory components in the subjects» house dust and asked whether any
of the factors correlated with an increased
of asthma at age seven.
We found that it is very selective and potent at stopping the growth
of blood vessel
cells without having negative effects on the growth
of other
cell types from the eye and elsewhere in the body.
In their latest work, reported online in the Journal
of Clinical Investigation, the scientists analyzed
blood from such mice and identified two
types of autoimmune response directed specifically against the protein, with the first response directed by a specialized kind
of immune system
cells called T
cells and the second by antibodies.