As a ciliated protozoan, Tetrahymena thermophila exhibits nuclear dimorphism: two
types of cell nuclei.
Not exact matches
First, an adult
cell would be removed from a patient and the DNA
of that
cell altered to control and direct the
types of gene expression the
nucleus is capable
of supporting.
This
cell -
type - specific analysis was essential to demonstrate that there is a close interplay between epigenetic mechanisms and the spatial folding
of the DNA in the cardiomyocytes»
nucleus.
Welte explains that the production
of certain proteins takes place along a
type of assembly line that carries raw materials from the
nucleus to the posterior end
of the egg
cell, where these proteins are then manufactured.
DNA from the
cell nucleus, which includes both maternal and paternal lines, tells a different story: The two
types of elephants are in fact separate species, leading recently to a proposed relisting
of the forest elephant as Loxodonta cyclotis.
To make sure she understood how
nuclei, dendrites, and axons came together to form different
types of brain
cells, she pulled out her crochet hook and went to work.
One group was born from eggs whose
nuclei had been replaced with genetic matter from a
type of cell called a cumulus
cell that surrounds the ovaries.
But like the medieval alchemists, today's cloning and stem
cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the
nucleus is still a mystery, and scientists have a lot to learn before they can direct a
cell's differentiation as smoothly as nature's program
of development does every time fertilized egg gives rise to the multiple
cell types that make up a live baby.
Before Katlyn showed up at NIH, the doctors there were already well prepared: They had inserted healthy human ADA genes into a modified mouse retrovirus — a
type of virus that can enter human
cells and transfer new genetic material right into the DNA strands in their
nuclei.
The researchers show that
cells of the same
type take up different amounts
of viral DNA into their
nucleus.
Packed into the
nucleus, DNA folds into a functional form that differs in various
types of cells.
We're manipulating genes in the
cell nucleus to produce specific proteins, changing the normal recipe for growth and maturation, and transforming adult
cells into a new
type of cell with the ability to morph into any other
cell type,» said Cooke, senior author and chair
of the Department
of Cardiovascular Sciences.
Organization
of the amplified
type I interferon gene cluster and associated chromosome regions in the interphase
nucleus of human osteosarcoma
cells.
Cell type specific chromosome territory organization in the interphase
nucleus of normal and cancer
cells.
With Dr. Bill Carlezon, Dr. McCullough is investigating the
cell -
type specific contributions
of neuron populations within the
nucleus accumbens to stress related pathologies.
Consequently, Spemann's work suggests that an embryonic
nucleus remains totipotent, or is able to develop into any
cell type of the adult body, even after several
cell divisions.
Due to the heterogeneous structure
of the brain, with many
nuclei and
cell -
types organized in complex networks, it is difficult to achieve a comprehensive overview in a 1 mm tissue sample.
Production
of a Quality Control Pipeline for Single
Nuclei RNA - seq and Its Application in the Analysis
of Cell Type Diversity
of Post-Mortem Human Brain Neocortex
The Society believes that research involving the transfer
of a human
nucleus into an animal egg will lead to important new knowledge about
cell nuclear replacement (CNR) technology and, if it were to prove possible to produce embryonic stem
cells by this route, would increase understanding
of how to programme these
cells to develop into different tissue
types.
Nuclei (green) from normal (wild
type, left) and mutant (crwn1, right) root
cells of Arabidopsis thaliana.