They are also working with collaborators to start classifying the thousands of
types of neurons found in the brain.
This would allow connections to grow between multiple
types of neurons found in distant parts of the brain,» said Dr. Marianela Garcia Munoz, Group Leader of the Brain Mechanism for Behaviour Unit.
There is nothing extraneous here in this painting of two pyramidal cells,
a type of neuron found in the cerebellum and hippocampus.
Apparently our gut holds the same
type of neurons found in brain so the gut is indeed our second brain.
Not exact matches
The study
found an increased risk
of cardiac schwannoma, a tumor
type that typically originates from cells
found in
neurons.
The team cemented its
finding by noting the mice's
neurons» ability to undergo long - term potentiation — a
type of response to stimulation, which has been implicated in learning processes — after gene function was restored.
In the direct reprogramming, the researchers exposed the adult skin cells to a specific mix
of signaling molecules the scientists» past research had
found would convert healthy skin cells directly into a
type of brain cell called medium spiny
neurons, without intermediate steps along the way.
Then the researchers doused dengue - spreading mosquitoes with a chemical that shuts down the mosquitoes» ability to detect CO2 by blocking a receptor called
neuron — cpA, a
type of sensory cell
found on a small pair
of antennalike structures near the mouth called the maxillary palps.
In a 2016 study, for example, Dokholyan's lab
found evidence that «trimer» structures made
of just three copies
of the SOD1 protein are toxic to the
type of neuron affected in ALS.
«By observing entorhinal - hippocampal
neurons based on their birthdate, we realized that these cells were somehow special and very different from the other surrounding cell
types, which was instrumental to
find out how and to what extent they influenced the assembly
of the network.»
«Our
findings open up exciting opportunities for further studying the roles
of different
types of neurons in health and disease,» said joint first - author Kwang Lee, a UCLA postdoctoral researcher in neurobiology.
«If you had a hunch that a certain
type of neuron might be important for a particular behavior,» he says, «you could use this technique to see if that's the case — to
find out whether activating those
neurons elicits the behavior artificially.»
For the first time researchers have linked a group
of neurons to a specific
type of somatosensation, a
finding that can open the door for a heightened understanding about our sense
of touch.
Researchers should be able to cultivate iPS cells into cell
types they want to study — for example, dopamine
neurons in the case
of Parkinson's or pancreatic cells for diabetes — and
find out where and how they go wrong.
If the gene expression profile
of a neuronal
type is measured, then the model predicts where in the brain that
type of neuron can be
found.»
To conduct the study, scientists took dental pulp cells from donated baby teeth
of three children with diagnoses
of non-syndromic autism (part
of the on - going «Tooth Fairy Project») and reprogrammed the cells to become either
neurons or astrocytes, a
type of glia or support cell abundantly
found in the brain.
They
found that individual
neurons in mPFC became activated in response to both «go» and «stop» environmental cues, suggesting that it may play a role in both
types of control.
Mamelak and Rutishauser
found that if a
neuron's response to an image synchronizes with a
type of brain wave called a theta rhythm, the person is much more likely to remember what was shown.
«This
finding suggests that there are two different
types of neurons, ESP1 and predator
neurons, and only the former controls sexual behaviors in female mice,» explains Touhara.
«Here we examined the performance
of sensory and motor
neurons in short - term memory, and
found that both
neuron types had impaired performance in old Aplysia.»
A good example
of compartmentalization is observed in a specialized
type of light - sensing
neurons found in the retina, the photoreceptors, which are made up
of different compartments containing specific proteins essential for vision.
Linda Buck
of the Fred Hutchinson Cancer Research Center and Richard Axel
of Columbia University, both winners
of the 2004 Nobel Prize in Physiology or Medicine, have
found that the human nose contains about 1,000 different
types of olfactory
neurons, each
type able to detect a particular set
of chemicals.
Further, the researchers
found that MMP - 9 can be detected not just in lumbar 5
neurons, but also in other
types of motor
neurons affected by ALS.
By comparing hippocampal and cortical
neurons in mono - culture (with other cells
of the same
type) and in co-culture (both cell
types deposited within one device), the research showed that some features from hippocampal cells, like the percentage
of action potential spikes
found in bursts, were significantly higher when cultured together with cortical cells.
Generally, scientists try to
find a unique marker, a sort
of molecular signature, to distinguish one
type of neuron from the many others in the brain.
Howard Hughes Medical Institute (HHMI) scientists have profiled key features
of the genetic material inside three
types of brain cells and
found vast differences in the patterns
of chemical modifications that affect how the genes in each
type of neuron are regulated.
«Our main challenge was to
find the right timing and concentration
of the signaling molecules that would yield V2a interneurons instead
of other neuronal cell
types, such as motor
neurons,» said first author Jessica Butts, a graduate student in the McDevitt lab.
In June the team announced that the cells had given rise to almost every
type of tissue —
neurons, blood, liver, muscle, and more (researchers have not yet spotted sperm or egg tissue but hope to
find them).
The cortex is the thin layer
of cells on the surface
of the brain that governs many functions, and in elephants it contains a greater variety
of cell
types (such as the extensively branched
neuron pictured above) than is
found in more frequently studied animals such as rodents and primates.
Using genetic tools to activate these two
neuron types with light, the scientists
found that stimulating one
neuron type caused mice to stop breathing completely, trapping them in a state
of exhalation.
Early in postnatal development, before this bouquet
of cells makes connections with other
types of neurons, the cells engage in cross-talk among themselves, Michael Hausser has
found.
A unique feature
of this DREADD system not
found in other methods is that it is not limited to the control
of neurons — activity levels
of certain enzymes in almost every tissue
type can be controlled to probe mechanisms
of basic cellular function.
They
found that the combination
of the transcription factors Brn3a plus Ngn1, or Brn3a plus Ngn2, reprogrammed a significant percentage
of the embryonic mouse fibroblasts into what looked — and acted — like mature DRG -
type sensory
neurons.
These problems are caused by a
type of white blood cells called T cells that, after becoming activated,
find their way into the brain and attack the protective covering — myelin —
of neurons in the brain and spinal cord, causing inflammation and damage to the central nervous system.
The ability
of scientists to convert human skin cells into other cell
types, such as
neurons, has the potential to enhance understanding
of disease and lead to
finding new ways to heal damaged tissues and organs, a field called regenerative medicine.
«New
type of neuron that plays key role in nicotine addiction
found.»
For the first 5 years, Spalding worked on
finding an effective way
of separating the roughly 20 million
neurons in the dentate gyrus from other
types of hippocampal cells and then extracting their DNA.
They also
found that the disruption
of the connectivity
of these cells during brain development causes alterations in brain oscillatory activity and disturbs the function
of place cells, a
type of pyramidal
neuron that becomes active when an animal is located in a particular place in its environment.
In studies
of neural development in mice, Stahl
found that TRNP1 produces a protein that determines whether neural stem cells self - replicate, leading to a balloonlike expansion
of cortical surface area, or whether they differentiate into a plethora
of intermediate stem cell
types and
neurons, thickening the cortex and forming more complex brain structures.
These cells also showed early markers that are specific to developing Purkinje cells, granule cells, or deep cerebellar projection
neurons — all
types of neurons only
found in the cerebellum.
How much
of it a cell sends across the synapse varies with the
type of neuron on the receiving end, they
found.
«So the total yield
of graft - derived
neurons and glia (a
type of brain cell that supports
neurons) were much higher than the number
of implanted cells, and we
found that in both the young and aged hippocampus, without much difference between the two.»
By selectively manipulating the different
types of neurons in this region, they
found that one set
of neurons controlled pursuit, and another controlled the kill.
He has
found that different receptors and
neurons contribute to different
types of olfactory behaviors, which are further modified with experience.
For example, they
found that the genes cut and numb, among others, influence the identity and
type of neurons made by their progenitors, and that the fruit fly gene atonal is implicated in vision and hearing.
We've been able to bridge those
findings to human studies, developing ways to both look for those
neurons in the retina, see whether or not they're sick using imaging techniques that Alf and Vivek have developed, and clinical tests along with Jeff Goldberg in order to detect whether or not patients are losing an excessive amount
of those kinds
of neurons by virtue
of different
types of field testing.
Jin
found that
types of neurons damaged in Parkinson's disease and Huntington's disease can broadcast the signals for starting or stopping newly learned action sequences.
Some cells differentiated themselves into various
types of the nerve cells (
neurons)
found in several brain regions, while others remained «neural progenitors,» creating a reservoir
of potential
neurons to be used later.
The site was able to
find many expected similarities between the different
types of neurons, and some similarities that were a surprise to researchers.
The text mining software
found the portions
of each paper that identified the
type of neuron studied and then isolated the electrophysiological data related to the properties
of that neuronal
type.