Not exact matches
Most experiments with human
stem cells have only shown that the
cells can acquire the phenotype
of various differentiated
cell types, but have not shown that the
cells are functional at the
transplantation site.
Horwitz et al 79 reported that donor MSC contributed to bone remodelling after allogeneic
stem cell transplantation (SCT) in 3 children with osteogenesis imperfecta, a rare genetic disorder
of type I collagen.
The current study involved monitoring the patients for one year after completed
stem cell transplantation and used mass cytometry to study the different
cell types of the immune system and the so called ProSeek method for simultaneous protein analysis.
Role
of hematopoietic
stem cells in steady state hematopoiesis It is remain not very clear if all blood
cell types are developed from one hematopoietic
stem cell (HSC) in normal hematopoiesis, because
of limitations
of conventional
transplantation models.
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The major gains in behavioral recovery and neuronal survival achieved by pre-differentiation
of glial precursors to specific, beneficial astrocytic
cell types prior to
transplantation stresses the need to consider such manipulations as a critical component in the optimization
of stem / precursor
cell transplantation based therapies.
Embryonic
stem cells derived from human blastocysts have the key advantage
of pluripotency, meaning that they form nearly all
cell types but also have the disadvantage
of forming tumors in vivo, which may limit clinical application to tissue engineering rather than
cell transplantation.
«Two decades
of discoveries in the fields
of stem cell biology, cortical brain development, and
cell transplantation have revealed the potential for particular
types of neurons to repair the nervous system, representing a possible breakthrough therapy for patients with devastating neurological diseases,» said Cory Nicholas, Co-Founder, VP
of Research at Neurona.
While there's growing interest in the use
of stem cell transplantation for treating
type 2 diabetes, not much research has looked at the use
of stem cells derived from bone marrow.
Their research focused on evaluating the safety and efficacy
of autologous bone marrow - derived
stem cell transplantation in individuals with
type 2 diabetes with good glycemic control as well, which emerged as an important aspect in the
transplantation group as well as in the non-transplanted group.
The other
type of therapy is autologous mesenchymal
stem cell transplantation.
One
type of stem cell transplant, autologous hematopoietic
stem cell transplantation, uses
stems cells from your own bone marrow, or from external umbilical cord blood.
Numerous studies have shown that
transplantation of a variety
of stem cell types into an injured spinal cord is safe and effective.