Not exact matches
Together with team members Dr. Rouzanna Istvánffy and Dr. Baiba Vilne, Oostendorp used mixed cultures
of tissue and
stem cells to investigate how the two
cell types interact.
By designing synthetic proteins that can only
interact with a pre-determined partner, and introducing them into
cells, the team revealed a key interaction that regulates the ability
of embryonic
stem cells to change into other
cell types.
The experiment shows that β1 - integrin — one
of 28
types of integrin — maintains a link between the
stem cell and its environment, and
interacts biochemically with a growth factor called fibroblast growth factor [FGF] to promote
stem cell growth and restoration after muscle tissue injury.