The researchers have tested the probe with many
types of tissue samples, but because it is currently designed for forward view mode, the primary applications of the probe would likely include skin, brain or head and neck surgery.
Not exact matches
Iwasaki and colleagues next added
type I interferon to
samples of human placental
tissue in dishes.
Using
tissue samples from five wild Amur tigers that died or were destroyed due to neurological disease in 2001, 2004, or 2010, McAloose and her colleagues proved that infection with CDV, a
type of morbillivirus, is to blame for the deaths
of two
of the tigers and caused a serious infection in a third.
To streamline this process, Uhlén's team has created standardized arrays containing microscopic
samples from 48 kinds
of normal human
tissue and 20
types of tumors.
The authors acknowledge that «tumor
tissue should be considered the preferred
sample type when available, however, our encouraging results suggest that a single plasma - derived ctDNA
sample may be considered appropriate for assessment
of EGFR mutation status when tumor
tissue is unavailable or exhausted.»
Instead, one
of the most challenging
types of samples is also the kind biomedical researchers are most likely to find interesting: formalin - fixed, paraffin - embedded (FFPE)
tissue.
The researchers next will turn to analyzing the presence
of myoferlin in
samples from numerous human tumor
types available in an Ohio State
tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the
samples.
«We can apply this method to any
type of clinical
sample and all
types of human
tissues, including normal and cancerous
tissues,» said co-lead author Yongxin Zhao, PhD,
of MIT's Media Lab.
In the illustration, each
tissue type is followed by the number
of genes whose level
of activity is controlled by nearby genes on the same chromosome (cis); those whose activity is associated with genes on other chromosomes (trans); and the number
of tissue samples studied.
The researchers profiled the microRNA in
samples of blood and heart
tissue from healthy people and people suffering from one
of two
types of heart failure, which develops when the heart's pumping action weakens, making it unable to deliver blood throughout the body.
Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets
of the cancer cells (subclonal) from tumor
tissue, the researchers detected a total
of 864 genetic changes in
tissue samples across the three tumor
types, and 627 (73 %)
of those were also found in the blood.
After analysing 113
samples of pancreatic cancer
tissue, the team found that 86 were infected with
types of bacteria that could make the long form
of the enzyme.
«Our subsequent examination
of these artificial
tissue samples revealed that various cell
types characteristic
of the midbrain had developed,» says Jens Schwamborn.
Clariom Pico assays can extract data from as little as 100 pg
of total RNA, from common and challenging
sample types (including formalin - fixed, paraffin - embedded
tissues and whole blood) without the need for globin messenger RNA reduction or ribosomal RNA removal.
Steve Horvath at the University
of California, Los Angeles, performed an analysis
of methylation in 7844
samples from 51 different
types of tissue.
For setting cancer in the context
of ageing
tissue, study
of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands
of non-cancerous cells and
samples from a range
of tissue types, in health and disease.
Root, sheath, and 4th leaf
tissues were
sampled from each
of three individual A10.1 wild -
type seedlings at 20 DAS (each representing a biological replicate).
Similar to other Unyvero Applications, Unyvero UTI allows the rapid detection
of pathogens and genetic resistance markers in a broad range
of routinely available patient
sample types, such as midstream urine, catheter urine, suprapubic aspiration, and
tissue.
Lappalainen is a collaborator on the Genotype -
Tissue Expression (GTEx) database (see table on opposite page), which includes genotyping and RNA sequencing from postmortem samples of multiple tissue
Tissue Expression (GTEx) database (see table on opposite page), which includes genotyping and RNA sequencing from postmortem
samples of multiple
tissue tissue types.
WISH The ideal way to do this kind
of analysis would be with large family data sets with diverse
tissue types, so that the researchers know the parental genotypes, but Lappalainen says only data sets from blood
samples are currently available.
Previous studies
of this
type relied on microscopic examination
of tissue samples from sacrificed animals, but this new approach allows researchers to watch the life or death
of cells in real time.
Tissue microarrays are used to show antibody staining in samples from 144 individuals corresponding to 44 different normal tissue types, and samples from 216 cancer patients corresponding to 20 different types of cancer (movie about tissue microarray production and immunohistochemical stai
Tissue microarrays are used to show antibody staining in
samples from 144 individuals corresponding to 44 different normal
tissue types, and samples from 216 cancer patients corresponding to 20 different types of cancer (movie about tissue microarray production and immunohistochemical stai
tissue types, and
samples from 216 cancer patients corresponding to 20 different
types of cancer (movie about
tissue microarray production and immunohistochemical stai
tissue microarray production and immunohistochemical staining).
Due to the heterogeneous structure
of the brain, with many nuclei and cell -
types organized in complex networks, it is difficult to achieve a comprehensive overview in a 1 mm
tissue sample.
The next step is to beef up the database
of molecular profiles with many more
samples of cancer
tissue beyond the four varieties that Eberlin and her team studied initially, including
types like brain cancer and melanoma.
In a study published recently in Cell, researchers at the University
of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree
of similarity between tumor
samples and pluripotent stem cells (cells that can differentiate into nearly any
type of tissue in the body).
Researchers looked at
tissue samples from the intestinal walls
of «447 newly affected and 221 non-affected people» and found an overabundance
of certain bacteria
types was linked to inflammation levels.
If your horse has an abnormal growth or abnormal appearing skin near his or her eye the best way to decide appropriate treatment is taking a
sample of this
tissue (a biopsy) and sending this to a pathologist to confirm the
type of mass or if the
tissue is abnormal on the cellular level.
Definitive diagnosis
of tumor
type relies upon microscopic examination
of tissue samples.
To tell the amount and
type of disease that is occurring in your pet's intestine requires a complicated intestinal biopsy.This is an intricate procedure that requires the use
of an endoscope to retrieve
tissue samples.
However, there can NEVER be a definitive diagnosis
of cancer
of any
type without a
sample of tissue being submitted to a pathologist for specialized testing.
One means
of determining the
type of cells involved in a mass is to do a fine needle aspirate (a needle is attached to syringe and inserted into the mass to collect a tiny
tissue or fluid
sample) and cytology (microscopic evaluation
of the cells).
She arranged for
tissue samples from the 4 affected dogs to be examined by the University
of California, Davis Neuromuscular Lab and although they originally diagnosed 4 different
types of muscular dystrophy, this was viewed with skepticism as 4
types would be highly unlikely (especially since 1 affected dog was a female and true muscular dystrophy does not affect females).
All standardization is a mathematical kludge necessitated by growth geometry and
sampling method (radial increment at two points — it would be preferable to know the volume
of tissue added each year and its allocation amongst the various
tissue types).
(ii) Except as permitted by paragraph (f)(2)(i)
of this section, the covered entity may not disclose for the purposes
of identification or location under paragraph (f)(2)
of this section any protected health information related to the individual's DNA or DNA analysis, dental records, or
typing,
samples or analysis
of body fluids or
tissue.
Comment: Several law enforcement agencies requested that the provision be broadened to permit disclosure
of additional pieces
of identifying information, such as ABO blood
type and Rh factor, DNA information, dental records, fingerprints, and / or body fluid and
tissue typing,
samples and analysis.
However, as explained below, protected health information associated with DNA and DNA analysis; dental records; or
typing,
samples or analyses
of tissues and bodily fluids other than blood (e.g., saliva) can not be disclosed for the location and identification purposes described in this section.