Sentences with phrase «types of tumors t»

Different CARs determine what types of tumors T cells target.

Not exact matches

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

Since the cancer cells in both types of tumors were the same, the researchers compared the noncancerous cells present in the induced and transplanted tumors to explore what might be causing the T cell apoptosis.

One advantage of this method is that it only activates a certain type of immune cell, the dendritic cell or T - cell, and only in one part of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.

OX40 functions as a throttle for T cells, another type of immune cell crucial for battling tumors, and the anti-OX40 antibodies rev up these cells.

«Not only did we find that LIGHT expression promoted tumor regression, upon further study we also identified the specific type of T - cell — CD8 — that was responsible for shrinking the tumor,» Maker said.

Tumors are home to diverse immune cell types, some of which remain much less explored than T cells and could also control cancer progression» says Mikael Pittet, PhD, director of the Cancer Immunology Program in the MGH Center for Systems Biology and senior author of the Science paper.

Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.

The research, published online May 26 by Nature Immunology, shows that GATA - 3 is required for the maintenance and function of CD8 + T - cells, a T - cell type mediating the immune response to clear pathogens, eradicate tumors and promote inflammation.

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumor develops, and how its progression is regulated,» says Ingegerd Elvers.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

Cells of the latter cancer types contain many DNA mutations, which are thought to make distinctive «neoantigens» that help the patient's immune system recognize and attack tumors, and make the cancer cells» «microenvironment» hospitable to tumor - fighting T cells.

«The apparent ability to change immunosuppressive T cells within the tumor into T cell types that are more active and potentially helpful against cancer was a really exciting finding, and one that we're continuing to investigate,» says Poznansky, who is an associate professor of Medicine at Harvard Medical School (HMS).

Immunity is key to long - term responses Knowing that the immune system is capable of recognizing distinctive features of cancer cells and launching a T cell attack against those tumor antigens, and that checkpoint blockade removes a roadblock to that attack, it's logical that these drugs should work against many tumor types.

While the study focused on the T - cells around a lymphoma tumor, this research is pertinent to all types of cancer.

Scientists have known that LPA is secreted by many types of cancer cells, appears to promote the growth and spread of tumor cells, and that immune cells known as CD - 8 «killer» T cells have several receptors for LPA.

Interestingly, p21 - deficient mice did not develop T - cell lymphomas, which is one of the most common tumor types in p53 - null mice (36, 37, 38).

Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T - cell response against different types of tumors.

It is interesting to note that p21 - deficient mice did not develop T - cell lymphomas, which is one of the most common tumor types in p53 - null and p19ARF - null mice (36, 37, 38, 42, 43).

So, the researchers forced expression of a dominant - negative TGF - β receptor type 2 (DNRII) onto LMP - specific T cells (DNRII - LSTs) that were specially designed to seek out and destroy proteins derived from the Epstein - Barr virus expressed by the tumor cells.

To get there, researchers will need to resolve certain obstacles associated with CAR - T, including further customization of the technology to recognize specific / other tumor types, and predicting and limiting cross-reactivity, where CAR - T immune cells start attacking healthy cells as well.

In cancer, Tregs are recruited by tumors and prevent other types of T cells, including cytotoxic T cells (also called CD8 cells) from attacking and destroying cancer cells.

For example, new data has shown that tumors that are infiltrated by T cells — a type of white blood cell that plays an important role in immunity — translate to better outcomes in response to immunotherapy.

T - VEC, recently approved for the treatment of advanced melanoma, is an oncolytic herpes simplex virus type 1 engineered to replicate selectively in tumor cells and express human granulocyte - macrophage colony - stimulating factor.

The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor necrosis factor and interleukin - 6, which stimulates the activity of macrophages, responsible for killing potentially harmful cells.

The tumors in the active mice contained more of two types of cancer - killing cells, explains Quartz, «double the number of T - cells and five times the number of natural killer cells.»