Sentences with phrase «types of tumors by»

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Male rats developed heart tumors when exposed to high levels of a type of radiation used by the wireless telephone industry, according to the draft studies released Friday.

Goji's are reported to have anti-aging properties and show anti-tumor activities against various types of skin cancer cells by inhibiting tumor growth and inducing apoptosis.

For example, TCGA, with genomic data on 33 tumor types taken from samples from 11,000 patients, is finishing 2018 by publishing a series of papers and holding a symposium.

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

New research led by Li Ding, Ph.D., of Washington University School of Medicine in St. Louis, shows that current approaches to genome analysis systematically miss detecting a certain type of complex mutation in cancer patients» tumors.

The tumors in Sand's lab might be explained by the high dose, the fact that the mice were newborns, and the type of mouse, suggests Kay, who was involved with a past clinical trial administering AAV to the liver to treat hemophilia.

The stem cell model says that tumor growth is more hierarchical, mainly driven by a subset of cells that can make new copies of themselves and give rise to the other cell types the tumor contains.

Because different types of tissue absorb emissions from the nanotubes differently, the scanner took readings from many locations to triangulate the tumor's exact location, as confirmed by later MRI scans.

The researchers also note that more investigation is needed to fully understand all the mechanisms by which HOXC10 mediates cell proliferation and death, and the roles it may play in different types of tumors.

«Enzyme could protect against type of colorectal cancer by suppressing tumors, study finds.»

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

If it is malignant, you need to know what type of tumor it is to choose the best treatment and that treatment needs to be carried out by specialist gynaecological cancer surgeon»

An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to a new study.

In a study published today in the British Medical Journal, an international team led by Imperial College London and KU Leuven, Belgium describe a new test, called ADNEX, which can discriminate between benign and malignant tumors, and identify different types of malignant tumor, with a high level of accuracy.

Low doses of aspirin, an anti-platelet drug, have been shown to reduce the risk of some types of gastrointestinal cancers, but the process by which aspirin hampers tumor growth has been unclear.

«Our findings suggest a simple strategy to kill metastatic melanoma — regardless of cell type within the tumor — by combining anticancer drugs with diabetes drug,» Herlyn said.

Patients were stratified by number of brain metastases (1 vs. 2 - 3), primary cancer type (melanoma vs. other histology) and pre-operative tumor size (less than vs. greater than three centimeters).

It is known that the genes that accumulate the most mutations are linked to the tumor type, and we found this too, however we showed that the mutational spectrum of a tumor is determined by breed type,» says Dr. Ingegerd Elvers, a researcher with Professor Kerstin Lindblad - Toh at both Uppsala University and Broad Institute.

«A number of other types of tumors have been shown to be driven by chimeras, but this one is unique — it codes for a kinase, an enzyme that modifies other proteins, that has not been identified in cancers.»

The research, published online May 26 by Nature Immunology, shows that GATA - 3 is required for the maintenance and function of CD8 + T - cells, a T - cell type mediating the immune response to clear pathogens, eradicate tumors and promote inflammation.

Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.

IL - 6 is a cytokine, a signal molecule that is produced and secreted both by immune cells and by tumor cells and binds specifically to a receptor (IL - 6R) that is found on the surfaces of many cell types.

The type of neuroblastoma studied by the investigators is distinguished by a glut of MYCN protein in the tumor cells.

These studies revealed that the void's physical characteristics — the type and location of missing bone — were consistent with a fibrous dysplastic neoplasm, a tumor caused by a bone growth disorder, the scientists report online today in PLOS ONE.

It also may have helped several others by boosting the power of a new type of cancer drug that uses a different mechanism to unleash an immune attack on the tumor.

So, for example, if one type of immunotherapy is used to knock out an inhibitory signal produced by a cancer, and the tumor responds by upregulating a second signal, an additional therapy could then be used to target this one as well, Lu says.

The study further suggests that NSAIDs such as aspirin, ibuprofen and naproxen have a particularly advantageous effect when taken after diagnosis by colorectal, or CRC, patients without tumor mutation in the KRAS gene (KRAS wild - type tumors): The study shows that NSAID use by this group is associated with a survival benefit of 40 percent.

However, despite this success, the use of immunotherapy remains limited by the scarcity of tumor - specific antigens — substances that can trigger an immune system response to a particular type of cancer.

Researchers leading the largest genomic tumor profiling effort of its kind say such studies are technically feasible in a broad population of adult and pediatric patients with many different types of cancer, and that some patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.

The types of tumor that can be particularly responsive to immunotherapy generally happen in older people, or people who have genetic factors that allow their tumors to acquire a lot of mutations — so that the tumor has a lot of different antigens that are recognized by the immunotherapy.

«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.

After identifying three different types of resistance to a promising investigational lung cancer drug in a phase 1 trial, a team of researchers led by Dana - Farber Cancer Institute scientists say new targeted inhibitors and combinations are urgently needed to stay ahead of tumors» constant and varied molecular shape - shifting.

By analyzing a dataset of human immune cells stimulated with interferon — a signaling protein created in response to pathogens or tumor cells — the team could precisely identify which genes were switched on in each of 13 responding cell types.

To verify these results, the researchers also used mice with APC deleted by traditional methods, and found the same types of tumors.

Scientists have known that LPA is secreted by many types of cancer cells, appears to promote the growth and spread of tumor cells, and that immune cells known as CD - 8 «killer» T cells have several receptors for LPA.

This made them suspect that by sharing exposure to various types of bacteria, the TAC mice had acquired microbes from JAX mice that somehow enhanced their immunity to tumors.

In the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph ntumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nTumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nodes.

In mouse models, carcinogen - induced tumors that arise in immunodeficient mice, when transplanted to wild - type mice, are usually eliminated by the intact immune system of the new host.

An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various types of cancer, the treatment shrank tumors in 28 percent of melanoma patients, 30 percent of patients with kidney cancer, and 18 percent of patients with advanced non-small cell lung cancer.

Molecular testing: Some primary brain tumors, including some of the most common types of gliomas, are defined by their key molecular features resulting from tumor cell mutations.

The current portfolio includes 12 clinical trials across 14 tumor types, led by world experts at centers of excellence throughout the U.S., E.U., and Australia.

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So, the researchers forced expression of a dominant - negative TGF - β receptor type 2 (DNRII) onto LMP - specific T cells (DNRII - LSTs) that were specially designed to seek out and destroy proteins derived from the Epstein - Barr virus expressed by the tumor cells.

There was also variation based on histology, with the highest rate of local recurrence at about a year after surgery seen in malignant peripheral nerve sheath tumors (MPNST), followed by myxofibrosarcoma; both those types saw persistently elevated rates compared to other subtypes out beyond 5 years.

Triple - negative breast cancer (TNBC), a tumor type defined by its lack of estrogen receptor, progesterone receptor, and Her2 (ERBB2) amplification, accounts for 16 % of breast cancers.

Tens of thousands of Americans with tumors from certain types of lung cancer have mutations that might be treated by...

«The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type,» by Mariia O. Yuneva et al., Cell Metabolism, Feb. 8, 2012.

The knowledge about how this cancer form arises and develops is still limited but new results from a research team led by Lene Uhrbom, Uppsala University / SciLifeLab, shows that disease progress and the malignancy are affected by the cell type from which the tumor originates as well as the age of the patient.