Consider Cushing's disease, in which any of several
types of tumors produce astronomically high glucocorticoid levels.
Not exact matches
«It's very difficult to
produce a mouse model
of a solid
tumor of the
type we see in most women who are diagnosed with cervical cancer.
With that knowledge, they screened more than four dozen monoclonal antibodies — unique agents that can stop cells from growing or forming
tumors and can be mass
produced — before finding two that block
tumor creation in both
types of cancer.
In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a
type of cell that lines the blood vessels), a perivascular macrophage (a
type of immune cell found near blood vessels), and a
tumor cell that
produces high levels
of Mena, a protein that enhances a cancer cell's ability to spread.
IL - 6 is a cytokine, a signal molecule that is
produced and secreted both by immune cells and by
tumor cells and binds specifically to a receptor (IL - 6R) that is found on the surfaces
of many cell
types.
So, for example, if one
type of immunotherapy is used to knock out an inhibitory signal
produced by a cancer, and the
tumor responds by upregulating a second signal, an additional therapy could then be used to target this one as well, Lu says.
When they compared the two
types of tumor — the localized ones lacking only the PTEN gene versus the metastatic
tumors lacking both genes — the researchers found that the metastatic
tumors produced huge amounts
of lipids, or fats.
Over 95 %
of colorectal cancers are adenocarcinomas, a
type of tumor that originates in the mucus -
producing glands
of the colon or rectum.
As we have previously suggested, since
tumor angiogenesis is very complex and involves a number
of different cell
types, a multi-target approach for the anti-angiogenic treatment
of cancer could be expected to
produce better results [18].
Morgridge computational biologist John Steill, another co-author
of the KinderMining study, is using the KinderMiner tool to improve gene marker lists, which have numerous uses such as classifying cells or samples by cell
type and identifying samples that may
produce tumors.
Pituitary
tumors are a
type of brain
tumor that can often mimic the function
of this gland,
producing extra hormones that your body doesn't need (and throwing your other hormones into disarray).