Sentences with word «tyrosine»

The jury remarked that the three laureates have participated independently in a chain of advances running from «the basic discoveries of tyrosine kinase proteins to clinical applications that save lives.»

The amino acid tyrosine found in protein sources like meat and fish is needed to make DOPA, which is then converted to dopamine in the body.

When postdoctoral researcher and first author, Karen M. Doody, Ph.D., screened samples from rheumatoid arthritis patients for the expression of phosphatases, she discovered that an enzyme known as RPTPσ, short for receptor protein tyrosine phosphatase sigma, is highly expressed on the surface of FLS.

Most common is the increased amount of tyrosine in the blood of premature infants, which is marked by decreased motor activity, lethargy and poor feeding.

Calcitriol, the hormonally active form of vitamin D, accumulates in the adrenals, and this stimulates the production of the gene for tyrosine hydroxylase, which is involved in serotonin production.

Approximately 10 - 15 % of Caucasian and 30 - 35 % of Asian patients with NSCLC have a mutation in the epidermal growth factor receptor (EGFR), which can be successfully targeted with EGFR inhibitors called tyrosine kinase inhibitors (TKI), such as erlotinib, gefitinib and afatinib.

CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis.

Physicians at Harvard Medical School have pioneered the use of 1 to 6 grams of tyrosine for the effective treatment of medication - resistant depression.

In this regard, one of the best models is IFN - stimulated JAK - STAT pathways, in which both STAT1 and STAT2 are activated by tyrosine phosphorylation in response to IFNs (4).

W Krzysciak at the Department of Medical Diagnostics at the Jagiellonian University in Poland, talks about aromatic amino acids like tyrosine, and that some of the diseases that are tied to amino acids include the diagnosing and treating of «social disorders, such as cancers; psychiatric disorders: depression, anxiety states, schizophrenia, bipolar affective disorders; neurodegenerative, and cardiovascular diseases; chronic kidney insufficiency or diabetes.»

[35] Additional animal studies confirm that cyanidin is four times more powerful an antioxidant than vitamin E. [36] The anthocyanin pelargonidin protects the amino acid tyrosine from the highly reactive oxidant peroxynitrite.

The thyroid gland converts the amino acid tyrosine into thyroglobulin, and attaches one to four iodine atoms to create T4 (thyroxine), the inactive storage hormone, T3 (triidothyronine), or metabolically active thyroid hormone, and two thyroid hormones whose clinical significance is less known, T2 and T1.

Almonds, avocados, lima beans, pumpkin seeds and sesame seeds also contain tyrosine.

TPA / capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR / WT, but not EGFR / KO cells.

He served as a member of the graduate faculty in the Department of Molecular Biology at Princeton University and spent 10 years at NIH where he madesignificant contributions to the discovery of a class of proteins known as tyrosine kinase oncogenes as key regulators of the immune system.

So, how much tyrosine do cats need?

He has done important research on tyrosine kinase receptors, most famously on HER2, which affects how tumors respond to chemotherapy in breast cancer patients.

Since many human cancers are driven by mutations increasing tyrosine kinase activity, these proteins and the molecules they interact with have come center stage as therapeutic targets.

In particular, the ones involved include Tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC)(9).

Binding to ephrin ligands on the surface of neighboring cells induces canonical signaling involving receptor clustering, autophosphorylation on tyrosine residues, and kinase activity - dependent downstream signaling.

An approach often used in treating CML is to block the Bcr - Abl activity using tyrosine kinase inhibitors (TKIs).

Induction by EGF and interferon - gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei

You can find tyrosine in red meat, chicken, fish, seafood, and seaweed.

Today, it is estimated that about a third of pharmaceutical research and development effort goes into targeting tyrosine kinase receptors and their signaling pathways for cancer therapies.

Howard Hughes Medical Institute researchers have combed through a catalog of all known tyrosine kinase enzymes to identify new gene mutations that occur in a significant fraction of colon cancers...

L - tyrosine also enhances the production of many crucial anti-aging hormones in the pituitary gland.

The use of tyrosine supplements leads to alertness and mental arousal.

(Moussa is listed as an inventor on a patent application that Georgetown University filed related to nilotinib and the use of other tyrosine kinase inhibitors for the treatment of neurodegenerative diseases.)

We also found Gasp was not tyrosine - phosphorylated upon TCR stimulation or PMA + ionomycin stimulation (Fig.

The cellular functions that Finch studied for his «second Ph.D.» included the activation of the gene that encodes tyrosine aminotransferase (TAT).

The newly uncovered pathway depends on activity of a protein called FER, a member of a family of proteins (called non-receptor tyrosine kinases) that add phosphate groups to other proteins.

Plants and microbes engineered to convert tyrosine into L - dopa may therefore serve as a source of this valuable material.

Many antipsychotic medications apparently function by inhibiting tyrosine metabolism.

During the past decade, data on the putative roles of STAT proteins in mediating gene expression without tyrosine phosphorylation have been accumulating.

Drugs like yohimbine which prolong the effects of tyrosine products have been used as an aphrodisiac.

A number of genetic errors of tyrosine metabolism occur.