Sentences with phrase «tyrosine kinase enzymes»

Howard Hughes Medical Institute researchers have combed through a catalog of all known tyrosine kinase enzymes to identify new gene mutations that occur in a significant fraction of colon cancers...

It inhibits two tyrosine kinase enzymes called Jak1 and Jak2, which rev up production of immune cells.

Not exact matches

Although the enzyme itself is inhibited in this state, it can be more easily re-activated through other tyrosine kinases.

The target for ibrutinib, an enzyme called Bruton's tyrosine kinase (BTK), is a key component of B - cell receptor signaling.

Based on the current study results, the team believes a particular enzyme, «dual specificity tyrosine - regulated kinase - 1a (DYRK1A),» is the likely target of harmine.

One reason may be that DDRs are protein enzymes known as tyrosine kinases that act as on and off switches of the cell self - cleaning process known as autophagy.

Transmission of signals in a cell is controlled by the coordinated activity of two families of enzymes: protein tyrosine kinases, which add a phosphate group to proteins, and protein tyrosine phosphatases, which remove them.

Regorafenib is one of a new generation of anti-cancer therapies that attack tyrosine kinases — enzymes that activate other proteins.

Some of those hits affect tyrosine kinases, enzymes that promote cancer by stimulating abnormal cell growth and proliferation.

Tyrosine is an amino acid present in proteins that contains a hydroxyl moiety, and kinases are enzymes that catalyze phosphorylation (addition of a phosphate group) of various substrates in the cell.

The researchers first identified the kinase domains of 138 tyrosine kinases and similar enzymes from the kinome database.

This reagent, an antibody that detects the phosphotryosine product of the tyrosine kinase reaction, proved crucial to Lydon's enzyme - activity measurements in cells.

In fact, numerous animal studies show that soy isoflavones interfere with an enzyme called tyrosine kinase in the hippocampus, a brain region involved with learning and memory.

One of soy's primary isoflavones, genistein, has been shown to inhibit the enzyme tyrosine kinase in the brain.