Sentences with phrase «tyrosine phosphatase»

A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2).

Currently there are several known genes associated with Hashimoto's thyroiditis: cytotoxic T - lymphocyte associated antigen 4 (CTLA - 4), human leukocyte antigens (HLA), protein tyrosine phosphatase 22 (PTPN22) and thyroglobulin receptor gene.

The protein tyrosine phosphatase 22 (PTPN22) like CTLA - 4 is an inhibitor of T cell activation.

Zinc is involved in insulin signaling by inhibiting the enzyme protein tyrosine phosphatase to increase phosphorylation of the insulin receptor.

The insulin receptor signaling cascade is inhibited by several phosphatases, including protein tyrosine phosphatase 1B (PTB 1B), phosphatase and tensin homolog on chromosome 10 (PTEN) and SH2 - domain - containing inositol phosphatase (SHIP2), all of which are inactivated by ROS.

Conjugated linoleic acid (CLA) up - regulates the estrogen - regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.

Foundation funding has had a great impact on Tonks» research, which has been largely focused on the protein tyrosine phosphatase (PTP) family of enzymes.

The low - molecular - weight protein tyrosine phosphatase (LMP...

PTPN22 is involved in the formation of a key protein known as lymphoid tyrosine phosphatase (LYP), which helps control the activity of T and B cells in the immune system.

I wanted to also introduce to you an important factor that's become a subject of great interest, and that is protein - tyrosine phosphatase 1B.

CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis.

Through a genetic screen in Drosophila, Igaki identified the ligand Sas and the receptor - type tyrosine phosphatase PTP10D as the cell - surface ligand - receptor system that drives tumor - suppressive cell competition.

Igaki identified the ligand Sas and the receptor - type tyrosine phosphatase PTP10D as the cell - surface ligand - receptor system that drives tumor - suppressive cell competition.

Protein Tyrosine Phosphatase - PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells.

Tyrosine phosphatase inhibitor triggers rodlet cell discharge in sunfish scale epidermis cultures.

Regulated expression of the receptor - like tyrosine phosphatase CD148 on hemopoietic cells.

Cutting edge: differential segregation of the SRC homology 2 - containing protein tyrosine phosphatase - 1 within the early NK cell immune synapse distinguishes noncytolytic from cytolytic interactions.

Ligand binding to inhibitory killer cell Ig - like receptors induce colocalization with Src homology domain 2 - containing protein tyrosine phosphatase 1 and interruption of ongoing activation signals.

When postdoctoral researcher and first author, Karen M. Doody, Ph.D., screened samples from rheumatoid arthritis patients for the expression of phosphatases, she discovered that an enzyme known as RPTPσ, short for receptor protein tyrosine phosphatase sigma, is highly expressed on the surface of FLS.

The complementary DNA that encoded the tyrosine phosphatase replaced the mitotic activator p80cdc25, closely associating the cdc25 (+)- activating pathway with tyrosine dephosphorylation of pp34.

In this study, it is shown that dephosphorylation of Tyr15 triggered activation of the pp34 - cyclin complex from fission yeast, that a human protein - tyrosine phosphatase can catalyze this event both in vitro and in vivo, and that activation of fission yeast pp34 does not require threonine dephosphorylation.

The drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which seems to contribute to cells losing their sensitivity to insulin.

In particular, protein tyrosine phosphatase, receptor type, F (PTPRF) may serve as a biomarker linking insulin resistance with insufficient milk supply.

It is an enzyme — one in a «superfamily» of 105 called protein tyrosine phosphatases (PTPs)-- that perform the essential biochemical task of removing phosphate groups from amino acids called tyrosines in other proteins.

Transmission of signals in a cell is controlled by the coordinated activity of two families of enzymes: protein tyrosine kinases, which add a phosphate group to proteins, and protein tyrosine phosphatases, which remove them.

Research Focus: My research projects are focused on the roles of protein tyrosine phosphatases (PTPs) in diabetes and rheumatoid arthritis.

Researchers have demonstrated that the enzymatic activity of R5 receptor - type protein tyrosine phosphatases is a requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells and could be a promising drug target for treatment.

While research in this area is still in the preliminary stage and remains mixed in terms of results, vanadium may help to increase our body's sensitivity to insulin by inhibiting a group of enzymes called protein tyrosine phosphatases.

Not exact matches

Navire Pharma is a new company aimed at developing novel small - molecule inhibitors of a tyrosine - protein phosphatase called SHP2 (also known as PTPN11) for genetically - driven and treatment - resistant cancer.

The University of Texas MD Anderson Cancer Center and BridgeBio Pharma today announced the launch of Navire Pharma, a biopharmaceutical company aimed at developing novel small - molecule inhibitors of a tyrosine - protein phosphatase called SHP2 for genetically driven and treatment - resistant cancer.

The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR.

In addition to causing the functional inactivation of these phosphatases, low concentrations of H2O2 or an oxidative shift in the GSH: GSSH redox status strongly increases the activity of the basic insulin receptor tyrosine kinase in the absence of insulin.