Sentences with phrase «tyrosine phosphorylated»

The role of tyrosine phosphorylated caveolin - 1 in regulating focal adhesion dynamics and cancer cell migration.

Induction by EGF and interferon - gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei

Administration of interferon - gamma (IFN - gamma) resulted in the appearance in liver nuclei of two tyrosine phosphorylated proteins (84 and 91 kilodaltons).

Not exact matches

Consequently, the STATs are phosphorylated at a single tyrosine site, become activated and dimerize.

Unlike IFNα - activated ISGF3 complex in which tyrosine - phosphorylated STAT proteins are required, IRF - 9 could successfully interact with either wt STAT2 or mutant STAT2 - Y690F in the absence of IFNα, although the interaction between IRF - 9 and wt STAT2 could be obviously enhanced by IFNα via tyrosine phosphorylation of STAT2 (Fig. 2A).

In addition, no tyrosine - phosphorylated STAT1 was detected in NB4 cells treated either by IFNα for 6 hours or by ATRA for 72 hours (Fig. 1A), further suggesting that the RIG - G gene expression was most likely activated through a novel mechanism.

To exclude this possibility, we constructed a phosphorylation - deficient STAT6 mutant in which the potential phosphorylated tyrosine at position 641 was mutated to a tryptophan (STAT6Y641W).

In contrast, the level of tyrosine - phosphorylated STAT1 increased rapidly, peaking at 10 minutes to 1 hour after IFNα treatment and then returning to the levels characteristic of untreated cells, whereas the level of tyrosine - phosphorylated STAT2 followed a similar time course but with a much slower decline (Fig. 1A).

Activated JAK kinases in turn phosphorylate - specific tyrosine motifs found in receptor domains, which then recruit the specific monomeric STATs to the receptor complex.

We also found Gasp was not tyrosine - phosphorylated upon TCR stimulation or PMA + ionomycin stimulation (Fig.