Sentences with phrase «tyrosine phosphorylation level»
The idea that both STAT2 and IRF - 9 were basic components necessary for RIG - G expression was also supported by the fact that ATRA could not only induce the total amounts of STAT2 and IRF - 9 proteins but also increase the tyrosine phosphorylation level of STAT2 in NB4 cells (Fig. 1A).
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At a molecular level, loss of insulin signaling in astrocytes impaired tyrosine phosphorylation of Munc18c.
The results revealed that the supernatant of 72 - hour ATRA - treated NB4 cells was sufficient to induce the tyrosine phosphorylation of STAT2 and the endogenous RIG - G level in U3A cells, in comparison with the relative consistent level of total STAT2 (Fig. 3B).
Similarly, increased level of STAT2 tyrosine phosphorylation was detected as well in IRF - 1 — transfected HT1080 cells (Fig. 4B).