Sentences with phrase «ubiquitin proteasome»

The ubiquitin proteasome pathway in neuropsychiatric disorders.

The 4 primary intracellular pathways that contribute to the regulation of skeletal muscle proteolysis are the autophagy / lysosomal, calpain - dependent, caspase - mediated, and ubiquitin proteasome (UP) systems.

When you get enough dietary protein, it reduces the activity of a complex inside cells called ubiquitin proteasome system.

Nurix is focused on discovering and developing therapies that modulate the ubiquitin proteasome system (UPS) for the treatment of a broad range of human disorders, most notably cancer.

Also of wide impact have been Goldberg's studies showing that the ubiquitin proteasome pathway is critical in the clearance of misfolded proteins and in muscle atrophy in many disease states, as well as in antigen presentation to the immune system.

Since 1997, it has been our mission to provide ubiquitin proteasome pathway (UPP) researchers with innovative tools that facilitate and accelerate drug discovery efforts.

His laboratory first demonstrated a new pathway for protein breakdown, now termed the ubiquitin proteasome pathway.

DUBs: The ubiquitin proteasome system represents an exciting and underexplored target class for treating many human diseases.

This research demonstrates that the technology combining BRET and ubiquitin proteasome system (UPS)- recognizable motifs is a breakthrough approach for fast and highly sensitive detection of tumours.

Not exact matches

They and others subsequently showed that ubiquitin then delivers the doomed proteins to the proteasome, a large complex that breaks down the chemical bonds holding proteins together and releases the amino acid building blocks for reuse.

Although some approved cancer drugs and others in development interfere with the same protein cleanup process, known as the ubiquitin - proteasome system, disulfiram targets only a specific molecular complex within this machinery.

The ubiquitin / proteasome system is known to regulate SMN protein levels; however whether autophagy controls SMN levels remains poorly explored.

As an example of our current studies, we have recently found that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by two kinases known as IKKβ and CK1α and consequently degraded by the proteasome via the SCFβTrCP ubiquitin ligase.

Progeria and lamin A processing in mammalian cells; ubiquitin - proteasome mediated protein quality control in yeast.

Palbociclib treatment increases proteasome activity independently of the ubiquitin pathway.

Cbl - b is an E3 ubiquitin ligase that targets multiple components of the TCR signal transduction pathway for degradation through the proteasome to facilitate termination of TCR signaling (19, 20).

Publication: A novel injectable BRET - based in vivo imaging probe for detecting the activity of hypoxia - inducible factor regulated by the ubiquitin - proteasome system.

Yeh TC, Bratton SB (2013) Caspase - dependent regulation of the ubiquitin - proteasome system through direct substrate targeting.

All cells depend on two main processes to clear excess proteins: the ubiquitin - proteasome system (UPS) and autophagy.

Ubiquitin ligases are involved in tagging proteins for degradation, they're very important in degradative mechanisms involving the proteasome.

Protein degradation: Two main mechanisms are involved in protein digestion, namely the lysosome — autophagy system and the proteasome — ubiquitin system [121].

Claudio Joazeiro Ph.D. studies the ubiquitin - proteasome system as a

This effect is mediated by an enhanced interaction of H2AX with the E3 ubiquitin ligase RNF168, which is associated with H2AX poly - ubiquitination and promotes its degradation by the proteasome.

Rick (Washington University, St. Louis) is an outstanding scholar and mentor who has made distinguished and sustained contributions to three broad areas of plant biology: the ubiquitin - proteasome system, autophagy, and phytochrome structure and signaling.

Since the ubiquitin - proteasome system (UPS) is another prominent mechanism for recycling of accumulated proteins, the observed upregulation of proteasomal genes may indicate diversion of protein catabolism towards the UPS.

The advantage of fish oil is that it seems to be doing both, as it has been shown to decrease the activity of the system that mediates muscle degradation, called ubiquitin - proteasome system.

It demonstrated an ability to inhibit the ubiquitin — proteasome pathway (UPP), the principal mechanism for protein catabolism.

«Skeletal muscle from animals randomized to PMI 5011 was demonstrated to have decreased 20S proteasome activity and reduced gene expression of specific proteins as part of the ubiquitin — proteasome system in skeletal muscle», they write.

BetaTOR decreases muscle protein breakdown through the ubiquitin - proteasome proteolytic pathway.

BetaTOR decreases the key regulative components and activity of the ubiquitin - proteasome proteolytic pathway, which results in less muscle protein loss.

Rigorous exercise has been shown to increase muscle protein breakdown through the ubiquitin - proteasome proteolytic pathway.

HMB results in decreasing the key regulating components of the ubiquitin - proteasome proteolytic pathway, which results in LESS muscle loss and damage.

HMB decreases protein breakdown caused by intense training at a molecular level by disrupting proteolysis through the ubiquitin - proteasome proteolytic pathway, the proteolytic enzyme that breaks muscle protein down.

Toll - like receptor 4 mediates lipopolysaccharide - induced muscle catabolism via coordinate activation of ubiquitin - proteasome and autophagy - lysosome pathways

Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin - proteasome systems by phosphatidylinositol 3 kinase

Amino acids and insulin act additively to regulate components of the ubiquitin - proteasome pathway in C2C12 myotubes