Sentences with phrase «ubiquitin system»

Protein degradation: Two main mechanisms are involved in protein digestion, namely the lysosome — autophagy system and the proteasome — ubiquitin system [121].

Because all the itchy mice had a defective version of the E3 ligase, Copeland suspects that their ubiquitin systems fail to tag immune - related defense proteins or foreign substances called antigens for disposal — both of which then might pile up and attract too many helper macrophages to the scene, wreaking havoc with the immune response.

Like many viruses, MERS works by hijacking the ubiquitin system in human cells composed of hundreds of proteins that rely on ubiquitin to keep the cells alive and well.

The Guardavaccaro group studies the functions of the ubiquitin system in normal cells and how deregulation of this system leads to oncogenesis.

Research in our laboratory focuses on studying the molecular mechanisms through which the ubiquitin system controls cell growth and proliferation and understanding how deregulation of this network contributes to malignant transformation.

He spent fifteen years there, studying first the structure and replication of chromosomes, before changing focus to the ubiquitin system, a new area of study at the time.

The work also illustrates yet another way that novel drugs may emerge from tinkering with the ubiquitin system.

Eric is a molecular and cellular biologist studying functions of the ubiquitin system, which, selectively targets proteins to be degraded by the proteasome, orchestrates responses to various stresses, and controls protein trafficking.

Recently, he has been focusing on the regulation of a family of yeast purine - cytosine permeases, including the transcriptional controls over their expression, and how, after these proteins bind to their cargo, they are targeted by the ubiquitin system for endocytosis and delivery to the vacuole.

For example, the ubiquitin system plays a key role in mounting the inflammatory response that combats microbial invaders and may, in addition, contribute to autoimmune disorders.

Some viruses, for example, exploit the ubiquitin system.

Achieving a detailed understanding of the design and functional significance of the ubiquitin system would require some means to perturb the ubiquitin system in cells.