Sentences with phrase «ubiquitin tags»

On its own, the released module becomes overactive, removing too many ubiquitin tags.

Aaron Ciechanover and Avram Hershko of the Rappaport Institute at the Technion - Israel Institute of Technology in Haifa and Irwin Rose of the University of California, Irvine, share this year's prize for work that established how a protein called ubiquitin tags other proteins for recycling.

This appears to be the first example of how the ubiquitin tagging mechanism found by Rose, Ciechanover, and Hershko is responsible for rendering a genetic switch ambiguous in a human embryo (or any other animal).

Not exact matches

PTEN tagged with multiple ubiquitin molecules can then be recognized and destroyed by the cell's protein degradation machinery.

Because all the itchy mice had a defective version of the E3 ligase, Copeland suspects that their ubiquitin systems fail to tag immune - related defense proteins or foreign substances called antigens for disposal — both of which then might pile up and attract too many helper macrophages to the scene, wreaking havoc with the immune response.

They added proteins that had been bound to the ER membrane, reasoning that only proteins involved in tagging would bind to the ubiquitin - tagging machinery in the filter.

To identify other proteins involved in the ubiquitin - tagging pathway, Sommer and his colleagues prepared special filters with ubiquitin.

In yeast that lack the gene for either Cue1p or Ubc7p, the misfolded protein remained in the ER and was never tagged with ubiquitin.

Phosphoarginine functions as a protein degradation tag in Gram - positive bacteria analogous to ubiquitin in eukaryotes.

If — as in the eukaryotic ubiquitin - based system — the access to the protease depends on a specific tag that must be carried by the substrate, then the important decision who and when should be eliminated boils down to the timely and selective attachment of tags.

It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as «the molecular kiss of death.»

His experiments showed that Ataxin - 7 anchors one of the complex's enzymatic modules, which is responsible for removing chemical tags called ubiquitin from DNA - packing proteins.

The signal for such destruction is provided by attachment of a small ubiquitous protein tag, called ubiquitin.

THE GREAT DIVIDE Young brain stem cells (one shown dividing, left) pack old proteins tagged with ubiquitin (red) into one daughter cell.

In this study, the researchers found that macrophages from mice lacking Smurf1 were unable to attach the death - tagging protein ubiquitin to intracellular bacteria, resulting in a failure of the autophagy pathway and runaway growth of the bacteria inside the cells.

During antibacterial autophagy, the bacteria get tagged with the protein ubiquitin, marking them for destruction by an organelle called the lysosome.

SUMOylation occurs when an enzyme attaches a molecular tag called a Small Ubiquitin - like Modifier (SUMO) to a protein, altering its activity and location in the cell.

«In the wake of our discovery, this kind of atypical ubiquitin - tagging by TRIM enzymes was found to be fairly common in antiviral immunity, and many TRIM proteins are now implicated in immune sensing and signaling,» says Gack.

Using biochemical methods, Gack found that an enzyme called TRIM25 activates RIG - I by tagging it with a protein called ubiquitin.

Ubiquitin ligases are involved in tagging proteins for degradation, they're very important in degradative mechanisms involving the proteasome.

Adding a tag called ubiquitin to the alpha synuclein prevents it sticking together into clumps (huntingtin does this too).

The Steffan laboratory is being funded by the Hereditary Disease Foundation to investigate how the Huntingtin protein interacts with the ubiquitin - tagged trash in order to scaffold it to the lysosome for degradation, and to figure out what kinds of trash may be cleaned up by Huntingtin.