Sentences with phrase «ubiquitination process»

«If this same alternative ubiquitination process occurs in humans, perhaps an engineered ubiquitin - editing protein could be developed to target and control processes critical to the development of many diseases, including infection,» Luo said.

The team found another unique aspect of the ubiquitination process is the use of a molecule named nicotinamide adenine dinucleotide, or NAD, as a source of energy.

Disease - causing pathogens have been shown to manipulate or attack the ubiquitination process to disarm immune cells and evade the body's defense mechanisms, he said.

Not exact matches

Moffitt researchers found that SIRT1 is modified by a process called ubiquitination, in which a small residue called ubiquitin is added to SIRT1.

Proteins can be regulated by a process called ubiquitination, in which an ubiquitin molecule is added to a protein.

In humans, there are about 100 proteins associated with ubiquitination, the process by which a protein labelled with ubiquitin is removed from the cell by specific cell machinery known as the proteosome.

This stepwise process, called ubiquitination, is critical for the cell to determine which proteins need to be removed.

The common cellular energy source Adenosine Triphosphate, or ATP, had been used in all other observed ubiquitination and was thought necessary for the process, he said.

Luo and Qiu lead a research team that identified an enzyme that could independently accomplish ubiquitination, an important cellular signaling process being pursued as a therapeutic target.

Given their in vivo role in pathogenicity, and based on the yeast two - hybrid interaction data, these results point to the importance of these pathogen proteins in modulating host ubiquitination pathways, phagosomal escape, and actin - cytoskeleton rearrangement processes.

The latter is responsible for wasting of skeletal muscle as the innate proteasomes destroy specific proteins through the process of ubiquitination.