The gene was revealed only in the affected children, but not in
the unaffected children of the families studied.
Not exact matches
About 3,100
of the participants are from simplex
families, with a single
child affected by autism but
unaffected parents and siblings; the remaining are from multiplex
families, which have two or more affected siblings.
Cold Spring Harbor, NY — A clinically extensive and mathematically powerful study
of 1000
families with one autistic
child and one
unaffected sibling has validated a controversial theory
of autism's complex genetic causation.
Using a newly assembled sample population called the Simons Simplex Collection which included about 1000
families, consisting
of both birth parents and in most cases two
children, one with ASD and the other
unaffected, Wigler and colleagues saw the earlier - observed effect, only «this time on a much larger scale.»