"Unaffected parents" refers to parents who are not influenced or emotionally impacted by a particular situation or event. They remain calm and unaffected regardless of what happens.
Full definition
Where unaffected parents were sequenced as well as the child, researchers saw a 10-fold reduction in the number of variants needing clinical evaluation.
two
unaffected parents and an affected offspring?
About 3,100 of the participants are from simplex families, with a single child affected by autism but
unaffected parents and siblings; the remaining are from multiplex families, which have two or more affected siblings.
There is little doubt that certain genetic mutations carried by
an unaffected parent can be transmitted to a child and cause the illness.
Since you are looking at inherited variation, will you be sequencing (perhaps in a targeted way)
unaffected parents, siblings or other relatives?
Here we applied whole - genome sequencing to 50 patients with severe ID and
their unaffected parents.
Unaffected parents can have affected offspring and if affected animals are bred together the offspring may not be affected.
Only 3 of the affected dogs had an affected parent, and breedings between an affected and
an unaffected parent could produce either all unaffected offspring or a mix of affected and unaffected offspring in the same litter.
The heritability index for the affected dogs, their littermates and
unaffected parents was 0.87.
In 37 of the litters born to
unaffected parents, one of the unaffected parents was related to other affected dogs.