Sentences with phrase «uncertain changes in the rate»

From the past few years, the state has faced uncertain changes in the rate of employment.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«Future land transitions are uncertain but relatively small changes in afforestation from agriculture resulted in substantial decrease in accumulation rates,» said Coulston.

The timing of these tax rate changes is still uncertain, but many believe they will be effective in 2016.

Further growth of Nevada's distributed PV sector, however, is uncertain because Nevada's Public Utility Commission recently approved several changes to the net - metering tariffs, including phasing in lower net - metering compensation rates and higher monthly fixed charges for distributed PV customers.

«Given the uncertain political climate after the elections and the start of the new «rate - payer impact statement» next year, we worry the window to achieve some of the most meaningful climate change legislation in over a decade will close at midnight Wednesday.»

My personal views are: (1) Yes, it is true that increasing greenhouse gas concentrations will tend to warm the Earth's surface and atmosphere; (2) Yes, human production of CO2 is producing significant increases in CO2 concentration; (3) The rates of change of temperature in the previous two millennia are uncertain because proxies have been misapplied by the hockey stick crowd.

In addition, the rate of warming for a given CO2 trajectory is sensitive to both positive (CO2) and negative (aerosol) forcings, and so higher sensitivity to both will change in the trend in an uncertain direction depending on the balance of these forcingIn addition, the rate of warming for a given CO2 trajectory is sensitive to both positive (CO2) and negative (aerosol) forcings, and so higher sensitivity to both will change in the trend in an uncertain direction depending on the balance of these forcingin the trend in an uncertain direction depending on the balance of these forcingin an uncertain direction depending on the balance of these forcings.

Thus absent dramatic changes in water resource management the long term prognosis is clearly one of acceleration — albeit at an uncertain rate.

Because the basics of anthropogenic global warming are fairly straightforward — CO2 is a greenhouse gas, because of the lapse rate water vapor condenses or freezes out in the troposphere and acts mainly to amplify the effect of CO2, humans are burning a lot of fossil C and increasing the CO2 in the atmosphere, the surface of the earth is warming, the cryosphere is retreating, the climate that supports civilization is rapidly changing, and consequently we are facing an uncertain future — but the details are complex, it's easy to «misunderestimate» the way climate works in detail.

Definitional variation over time also means that we are uncertain as to how much of the change in the cumulative risk for confirmed maltreatment is due to actual changes in rates of maltreatment vs changes in definitions of maltreatment.

While these two variables — how much the interest rate will change and over what period of time — remain uncertain in each cycle, what is absolutely certain is that interest rates will rise and drop over time as the interest rate cycle completes itself.