Sentences with phrase «uncertain future changes»

Specification now of a CO2 target more precise than < 350 ppm is difficult and unnecessary, because of uncertain future changes of forcings including other gases, aerosols and surface albedo.

Our framework links innovative approaches for (1) generating high - resolution, probabilistic projection of future climate and sea - level changes and (2) empirically identifying robust statistical relationships characterizing how humans have responded to past climate variability and past climate change, in order to (3) project how humans may respond to uncertain future changes.

Specification now of a CO2 target more precise than < 350 ppm is difficult and unnecessary, because of uncertain future changes of forcings including other gases, aerosols and surface albedo.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Why should Connecticut legislators change the law this year when Tesla is still a fairly young company with an uncertain financial future, the car dealers say.

The entry of Amazon and its partners adds to the upheaval in an industry where much is changing, from government programs after the overhaul of the tax law to the uncertain future of the Affordable Care Act.

However, what does not change in our investment process is the constant application of fundamental research to identify the best stocks and bonds with which to confront an ever - changing and uncertain future.

The future of bitcoin is uncertain, but with continuous positive gains over the past several years and an expanding interest in the development of blockchain, the technology is set to bring change to society in one way or another.

The Coptic Church faces an uncertain future in the wake of the recent departure of its leader, Pope Shenouda III, and the sweeping political change occurring in Egypt.

«As a people we are more confused, lacking in moral ideals, dreading the future, uncertain what to do to change things or how to rescue our own inner life.»

In the event that they are forced into a managerial change though, the report claims that Spalletti has emerged as a real possibility as with his contract running down in the Italian capital, he may well face an uncertain future of his own.

Wenger is ding to please fund for the first time, if that's the case, let him hurry with the deal so that we are free from contradicting statements always, remember we as well need lemar coz Alexis future is uncertain, he may change his mind anytime....

Alexis has been the stand - out star in North - London over the past couple of seasons, and that doesn't look set to change despite his uncertain future.

«While ozone depletion from dichloromethane is currently quite modest, it is uncertain how the amount of this gas in the atmosphere will change in the future.

Instead of providing a nice, neat and clear answer, the findings showed that the effect of future climate change on agriculture is wildly uncertain.

«Future land transitions are uncertain but relatively small changes in afforestation from agriculture resulted in substantial decrease in accumulation rates,» said Coulston.

The future impacts of anthropogenic global change on marine ecosystems are highly uncertain, but insights can be gained from past intervals of high atmospheric carbon dioxide partial pressure.

That suggests the white - coated, massive bears have weathered previous natural climate changes, and may predate the Arctic ice that is their preferred — and only — habitat today, which is why the species future remains uncertain presently.

The researchers warn, however, that the future evolution of the AMO remains uncertain, with many factors potentially affecting how it interacts with atmospheric circulation patterns, such as Arctic sea ice loss, changes in solar radiation, volcanic eruptions and concentrations of greenhouse gases in the atmosphere.

Of the many inane arguments that are made against taking action on climate change, perhaps the most fatuous is that the projections climate models offer about the future are too uncertain to justify taking steps that might inconvenience us in the present.

This combination of uncertain projections, local and global effects, and potential for human adaptation makes it difficult to attribute current, much less future, changes and trends in Montana agriculture solely to climate change.

It is of interest to scientists because it is changing rapidly; it is thinning, accelerating and receding3, all of which contribute directly to sea level, and its future under a warming climate is uncertain.

Sugarcane has brought wealth to the world's last absolute monarchy, but climate change spells an uncertain future for this thirsty crop

The second thread links uncertain projections of future changes to statistical and process models of human systems to assess the risks posed by climate change.

When change strikes, it's easy to let your mind spin out, worrying about what the uncertain future will bring.

Last month I still wrote about how uncertain my future is and then June showed me how fast everything can change!

«But the uncertain future of the system - weighted average, as well as radical changes to the fee expectations for Catholic primary schools, means principals and families are increasingly worried about the affordability of Catholic schools in coming years.»

Young people today face an uncertain future: changing political and economic alliances, the impact of Brexit and shifting global alliances.

Today's learners face an uncertain present and a rapidly changing future that demands far different skills and knowledge than we needed in the 20th century.

However it is important that any decisions about a change of status for a school are taken for sound educational reasons, not because of misunderstanding over the current law or fear of an uncertain future.

But at a time of funding pressure and curriculum changes, the future of arts education in schools is uncertain.

2016 is clearly a year of change and in times where the future is uncertain, knowledge and understanding of human history and behavior become more important than at other times.

An unnamed source tells Bloomberg that the company normally would have had an upgrade plan for BlackBerry 10 in place by now but that the firm did not want to commit to a platform that faces an uncertain future now that BlackBerry is pondering a change in direction.

The future of the Stafford loan program is uncertain (as is just about any federal aid program for higher education) but it does appear that Congress is looking at a proposal to change the Stafford Loan interest rates from a fixed rate to a variable rate and making 6.8 % the maximum percentage rate that will be allowed to be imposed on borrowers.

According to a new Morningstar report, the Obama - era Department of Labor (DOL) conflict of interest reforms, while facing an uncertain future, have already promoted real change among advice and investment product providers working under the Employee Retirement Income Security Act (ERISA).

With another interest rate hike now on the books, the change has some Canadians uncertain about their financial future.

The landscape of retirement has changed dramatically over the last few decades, however, and with traditional pension plans dwindling, the future of Social Security uncertain, the rising costs of health care, and now retirement right around the corner, people are rethinking their approach to retirement income.

Greco acknowledged the support of the county freeholders and administration as the shelter faced an uncertain future with increased costs due to recent court rulings and health code changes.

Our Xbox show dissects the radical shift at EA that's resulted in the closure of Visceral Games, a change in direction for their Star Wars game, and an uncertain future at EA for Amy Hennig.

«Our future is uncertain, they will eventually make us move out... I'm not afraid of changes, I just hope I can afford them,» said Shamim from Robin Hood Gardens in London, currently under demolition.

Vague fears, barely palpable anxieties and underlying threats shape an attitude to life that has lost a lot of its serenity somewhere between a changing present and an uncertain future.

This panel discussion will address questions of how artists use digital technology to mark current conditions and evoke uncertain futures — How can we make future climate change seem real to the present?

Future changes in the polar vortex appear to be quite model dependent, and so predictions of this aspect of polar change are highly uncertain.

This failure is a little strange as the assessed scale of future permafrost CH4 emissions are plain within the paper's Fig 6 while Section 6.4 — Sensitivity of Permafrost Methane Fluxes to Climate Change concludes «The potential strength of the permafrost CH4 feedback may be considered small through to 2100 but remains uncertain at these and longer timescales.»

This could then lead to a wider debate about how best to respond to climate change risks in a complex world with an uncertain future.

I'm not a climate change denier, but at the same time I think we sometimes fail to recognize how uncertain the future is.

it seems that your conclusion:» the observed relationship between increased intensity of TCs and rising ocean temperatures appears to be robust» is in direct contradiction with your conclusion «our knowledge of likely future changes in hurricanes or tropical cyclones (TCs) remains an uncertain area of science».

Maybe he considers the significant effects of climate change to be uncertain enough, or far enough in the future as to not be relevant to his topic of discussion.

We should think of climate change mitigation as an investment for which the fair price and future yield is uncertain but presumed positive.

Of the many inane arguments that are made against taking action on climate change, perhaps the most fatuous is that the projections climate models offer about the future are too uncertain to justify taking steps that might inconvenience us in the present.