Sentences with phrase «uncertain resulting in»

The Court of Appeal upheld a lower court's decision that the testator intended to create a trust but the trust failed since the objects of the trust were uncertain resulting in an intestacy.

Not exact matches

«The overall atmosphere in the small - business community is uncertain regarding SBA lending,» says Solomon, and that results in business owners putting the brakes on expansion plans and holding off on making the next hire.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

So while all of this creates great opportunity, 82 percent of CEOs say it is also resulting in deeply uncertain economic growth when the only predictable thing about the landscape is that it will keep shifting.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The gamble for a CEO is a risk that must be taken when aspiring to move the business forward, and you must accept the uncertain future of your bet in that it could also result in costing your job.

Many supporters of delay also argued that the President's Memorandum has rendered the ultimate fate of the Fiduciary Rule and PTEs uncertain and that proceeding with the April 10, 2017 applicability date in the face of this uncertainty would impose unnecessary costs and burdens on the financial services industry and result in unnecessary confusion to investors inasmuch as products, services, and advisory practices could change after completion of the examination.

The Greater Vancouver Board of Trade has released results from its first post-election Member Survey, which found that businesses across the Lower Mainland are anxious about the province's economic future given the uncertain political situation in Victoria.

The referendum results showed a majority of those voting in favour of leaving the European Union, although the next steps remain highly uncertain.

Investing in a volatile and uncertain commodities market may cause a portfolio to rapidly increase or decrease in value, which may result in greater share - price volatility.

Moreover, our international expansion efforts have resulted and will continue to result in increased costs and are subject to a variety of risks, including increased competition, uncertain enforcement of our intellectual property rights, more complex distribution logistics, and the complexity of compliance with foreign laws and regulations.

As the industry evolves, the underlying ideals of progress and potential portend a steady march towards the stars — but the long - term results of this remarkable moment in time are uncertain.

VANCOUVER, B.C. — The Greater Vancouver Board of Trade has released a subset of results from its first post-election Member Survey, which found that businesses across the Lower Mainland are anxious about the province's economic future given the uncertain political situation in Victoria.

Investing in a volatile and uncertain commodities market may cause a portfolio to rapidly increase or decrease in value which may result in greater share price volatility.

Mathematics is ordinarily considered as producing precise and dependable results; but in the stock market the more elaborate and abstruse the mathematics the more uncertain and speculative are the conclusions we draw therefrom.

Although the path for negotiations on the United Kingdom's departure from the European Union (EU) remains uncertain, the French presidential election result has removed another potential political risk that may have been holding back activity in some parts of Europe.

But link building can seem like an onerous task to undertake, full of trade secrets and treacherous mistakes waiting for the uncertain beginner that may doom their efforts to rise in the search engine results pages (SERPs).

As a result, the US federal income tax consequences of investing in Shares are uncertain and alternative characterizations are possible.

Speaking about the timing of the walk so close to the General Election results, Linda Corrigan from the worldwide Christian community Maranatha told Premier: «Surely our nation needs the Body of Christ to give united leadership in these uncertain and turbulent times, especially following the recent atrocity in the city of Manchester.»

Harry Angstrom is indeed caught in the hard passage from youth to age, and he negotiates the narrow divide between the angels and the apes with only uncertain results.

Results: In the two groups uncertain about receiving intercessory prayer, complications occurred in 52 % (315/604) of patients who received intercessory prayer versus 51 % (304/597) of those who did not (relative risk 1.02, 95 % confidence interval 0.92 - 1.15In the two groups uncertain about receiving intercessory prayer, complications occurred in 52 % (315/604) of patients who received intercessory prayer versus 51 % (304/597) of those who did not (relative risk 1.02, 95 % confidence interval 0.92 - 1.15in 52 % (315/604) of patients who received intercessory prayer versus 51 % (304/597) of those who did not (relative risk 1.02, 95 % confidence interval 0.92 - 1.15).

The result of this international circus was a very uncertain voice at the Diet in Germany, presided over by the Emperor's brother Ferdinand, who attempted once again to get agreement to the formal execution of the decisions of the Diet of Worms.

Football like life is uncertain... What is certain however is that following the same failed strategy year after year and expecting a different result is a sign of ineptitude if not madness... Our best 11 ain't up to it largely because it doesn't threaten and unthreatened teams also mean there is more pressure on our defence as well... So a bit of tinkering in the middle of park ain't going to deliver titles that is for sure... Draxler plus a mobile striker is needed... So unless the idiote grenouille is willing to shelve out 80m can kiss titles goodbye now... He can recover 30 - 40m with obvious sales of mediocre attacking options so not too onerous but at this rate it's déjà vu all over again

As a result Kolarov faces an uncertain future at City according to the Manchester Evening News but he did feature in the pre-season friendly against Borussia Dortmund.

Another disappointing result, this time against Swansea City, leaves Paul Lambert's future in doubt but he is not the only one who is uncertain...

Damien Delaney is entering the twilight of his career while the future of Scott Dann remains uncertain and as a result, Pardew is scouring the market in his search for a centre back.

The vote in 2007 was itself an FPTP vote on the future of the Lords, rather than a preferential vote, and I remember it being couched in no uncertain terms at the time as 100 % being the obstreperous option that would result in Lords reform progressing the slowest; indeed, despite wide - ranging support in the Commons for 100 % elected Lords, the Labour government indeed made no progress whatsoever on such legislation.

The potential quantity and grade is conceptual in nature, there has been insufficient exploration to define a Mineral Resource and it is uncertain if further exploration will result in discovery of a Mineral Resource.

With the results still uncertain in Rep. Charlie Rangel's most difficult primary battle so far, attention has turned to the opening of absentee and affidavit ballots by the city Board of Election.

But the recent fluctuations in prices that were likely the result of the drastic increase in residents» power bills point to an uncertain future.

The prospects for any of those reforms passing both legislative houses is uncertain, especially considering the bad blood between Cuomo and lawmakers that was exacerbated by the scuttling of plans for a proposed December special session, which could have resulted in the first legislative pay increase since 1999.

She has written to Mr Cameron and the five leadership candidates to say EU citizens in Scotland are «understandably anxious and uncertain» about what the referendum result means for them.

The results for breast cancer are in line with previous research, but the true effect of alcohol on risk of ischaemic heart disease remains uncertain, say the editorial authors.

The company receives up to 40 requests a day for test results, and «99.9 % of them,» Rogers says, are for the usual pathogenic or uncertain variants, the kind included in the company's patient reports.

«Terrorism and human - caused disasters can have strong impacts on communities because of their uncertain and long - lasting nature, resulting in long - term stress and disruption,» Watson notes.

As a result, the number, size, location and organization of workshops involved in producing the emperor's ceramic troops remain uncertain.

«Future land transitions are uncertain but relatively small changes in afforestation from agriculture resulted in substantial decrease in accumulation rates,» said Coulston.

The results of his study have now been published in the journal Developmental Psychology, and the title of the paper, «It's Payback Time,» answers the question in no uncertain terms.

Climate change effects on the geographical distribution and incidence of vector - borne diseases in other countries where these diseases are already found can also affect North Americans, especially as a result of increasing trade with, and travel to, tropical and subtropical areas.63, 197 Whether climate change in the U.S. will increase the chances of domestically acquiring diseases such as dengue fever is uncertain, due to vector - control efforts and lifestyle factors, such as time spent indoors, that reduce human - insect contact.

Many aspects of this extreme glaciation remain uncertain, but it is widely thought that the breakup of the supercontinent Rodinia resulted in increased river discharge into the ocean.

Those pollsters who do seek a more thorough understanding of public attitudes find a marked lack of knowledge of the basic facts and even an acknowledgment of that ignorance — resulting in uncertain and highly malleable opinions.

Long - term (decadal and multi-decadal) variation in total annual streamflow is largely influenced by quasi-cyclic changes in sea - surface temperatures and resulting climate conditions; the influence of climate warming on these patterns is uncertain.

This lack of positive communication allows the voices of those opposed to animal research to dominate public discourse; «alternative facts» become perceived truths with the result that public and political opinion is often uncertain on the use of animals in research.

I'm neurotic about finishing what I start but I've been equally fervent in avoiding actions where I'm uncertain of the result.

More experienced surgeons were less likely to overreact, but even one out of four doctors in that group said they would treat uncertain results the same as a BRCA mutation.

For many women, when it's time to date again, they're uncertain of the steps they need to take for doing the work that results in finding Quality Men to date.

For many women, when it's time to date again, they're uncertain of the steps they need to take to do the work that results in finding Quality Men to date.

Whether such material has captivated readers and viewers as much as Katniss» relatable plight, the result of a noble volunteering in her younger sister's place, and her love triangle with Peeta and local heartthrob Gale Hawthorne (Liam Hemsworth) is uncertain.

The surprise is that this kind of personality - based trick has resulted in the most searching and affecting performance of the actor's career: his Ivan is an organized, surface - only wastrel who has admitted to his limitations and made peace with them, beautifully balancing the title character's uncertain yearnings.

Whether the shared systematic model would produce similar results in district schools serving different families is uncertain.