Sentences with phrase «uncertain results of»

Not exact matches

At the best of times, everything a CMO does is a gamble with ephemeral and uncertain results; that's a hundred times truer now, with marketing tools multiplying faster than anyone could truthfully claim to keep up with.

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

So while all of this creates great opportunity, 82 percent of CEOs say it is also resulting in deeply uncertain economic growth when the only predictable thing about the landscape is that it will keep shifting.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The gamble for a CEO is a risk that must be taken when aspiring to move the business forward, and you must accept the uncertain future of your bet in that it could also result in costing your job.

Many supporters of delay also argued that the President's Memorandum has rendered the ultimate fate of the Fiduciary Rule and PTEs uncertain and that proceeding with the April 10, 2017 applicability date in the face of this uncertainty would impose unnecessary costs and burdens on the financial services industry and result in unnecessary confusion to investors inasmuch as products, services, and advisory practices could change after completion of the examination.

The Greater Vancouver Board of Trade has released results from its first post-election Member Survey, which found that businesses across the Lower Mainland are anxious about the province's economic future given the uncertain political situation in Victoria.

The referendum results showed a majority of those voting in favour of leaving the European Union, although the next steps remain highly uncertain.

Moreover, our international expansion efforts have resulted and will continue to result in increased costs and are subject to a variety of risks, including increased competition, uncertain enforcement of our intellectual property rights, more complex distribution logistics, and the complexity of compliance with foreign laws and regulations.

As the industry evolves, the underlying ideals of progress and potential portend a steady march towards the stars — but the long - term results of this remarkable moment in time are uncertain.

VANCOUVER, B.C. — The Greater Vancouver Board of Trade has released a subset of results from its first post-election Member Survey, which found that businesses across the Lower Mainland are anxious about the province's economic future given the uncertain political situation in Victoria.

Results from APF Canada's 2012 National Opinion Poll indicate that 31 per cent of Canadians have never heard about the TPP, while 11 per cent are uncertain about their stance on the agreement.

As such, it is uncertain that use of an enhanced cell processing method will yield different results.

Although the path for negotiations on the United Kingdom's departure from the European Union (EU) remains uncertain, the French presidential election result has removed another potential political risk that may have been holding back activity in some parts of Europe.

But link building can seem like an onerous task to undertake, full of trade secrets and treacherous mistakes waiting for the uncertain beginner that may doom their efforts to rise in the search engine results pages (SERPs).

As a result, the US federal income tax consequences of investing in Shares are uncertain and alternative characterizations are possible.

Finally, preoccupation with the fascinations of progressive scientific discovery and with the material products of technology has turned man's attention away from the more uncertain and outwardly less rewarding results of the religious life.

Speaking about the timing of the walk so close to the General Election results, Linda Corrigan from the worldwide Christian community Maranatha told Premier: «Surely our nation needs the Body of Christ to give united leadership in these uncertain and turbulent times, especially following the recent atrocity in the city of Manchester.»

As a result, the status of signs set up by humankind is utterly uncertain, gratuitous, and vain.

Results: In the two groups uncertain about receiving intercessory prayer, complications occurred in 52 % (315/604) of patients who received intercessory prayer versus 51 % (304/597) of those who did not (relative risk 1.02, 95 % confidence interval 0.92 - 1.15).

The result of this international circus was a very uncertain voice at the Diet in Germany, presided over by the Emperor's brother Ferdinand, who attempted once again to get agreement to the formal execution of the decisions of the Diet of Worms.

Football like life is uncertain... What is certain however is that following the same failed strategy year after year and expecting a different result is a sign of ineptitude if not madness... Our best 11 ain't up to it largely because it doesn't threaten and unthreatened teams also mean there is more pressure on our defence as well... So a bit of tinkering in the middle of park ain't going to deliver titles that is for sure... Draxler plus a mobile striker is needed... So unless the idiote grenouille is willing to shelve out 80m can kiss titles goodbye now... He can recover 30 - 40m with obvious sales of mediocre attacking options so not too onerous but at this rate it's déjà vu all over again

Damien Delaney is entering the twilight of his career while the future of Scott Dann remains uncertain and as a result, Pardew is scouring the market in his search for a centre back.

Intrapartum ultrasonography has been used to increase the accurate diagnosis of fetal position when the digital examination results are uncertain (47).

However, much of this evidence relates to singleton infants; although some studies include multiples, results are not usually reported separately, therefore applicability to infants from multiple pregnancies is uncertain (Renfrew 2009).

The prospect of a referendum with an uncertain result has already caused a great deal of disarray, and those who count the costs of a possible Brexit...

The result of the referendum on 18 September is very uncertain, but its effects have already been felt.

The vote in 2007 was itself an FPTP vote on the future of the Lords, rather than a preferential vote, and I remember it being couched in no uncertain terms at the time as 100 % being the obstreperous option that would result in Lords reform progressing the slowest; indeed, despite wide - ranging support in the Commons for 100 % elected Lords, the Labour government indeed made no progress whatsoever on such legislation.

The potential quantity and grade is conceptual in nature, there has been insufficient exploration to define a Mineral Resource and it is uncertain if further exploration will result in discovery of a Mineral Resource.

With the results still uncertain in Rep. Charlie Rangel's most difficult primary battle so far, attention has turned to the opening of absentee and affidavit ballots by the city Board of Election.

But the recent fluctuations in prices that were likely the result of the drastic increase in residents» power bills point to an uncertain future.

The prospects for any of those reforms passing both legislative houses is uncertain, especially considering the bad blood between Cuomo and lawmakers that was exacerbated by the scuttling of plans for a proposed December special session, which could have resulted in the first legislative pay increase since 1999.

The authors note that the contribution of ribavirin to SVR12 remains uncertain because of the small sample sizes; results suggest that inclusion of ribavirin with the regimen may be considered for patients with genotype 1a infection.

The results for breast cancer are in line with previous research, but the true effect of alcohol on risk of ischaemic heart disease remains uncertain, say the editorial authors.

The company receives up to 40 requests a day for test results, and «99.9 % of them,» Rogers says, are for the usual pathogenic or uncertain variants, the kind included in the company's patient reports.

«Terrorism and human - caused disasters can have strong impacts on communities because of their uncertain and long - lasting nature, resulting in long - term stress and disruption,» Watson notes.

As a result, the number, size, location and organization of workshops involved in producing the emperor's ceramic troops remain uncertain.

The results of his study have now been published in the journal Developmental Psychology, and the title of the paper, «It's Payback Time,» answers the question in no uncertain terms.

However, the results on severe and serious adverse events (e.g. pain), on discontinuation due to such events and on occurrence of diarrhea were uncertain.

Though focused on end uses of natural gas, the paper also shows how results are affected by highly uncertain leak rates from natural gas production and delivery.

The impact of these mutations remains uncertain, but many scientists say it is plausible that our temperament or reasoning abilities shifted as a result.

A review of the finds from the Troisième caverne of Goyet combined results from various disciplines; it identified 99 previously uncertain bone fragments as Neanderthal bones.

Ory said of the more than 5,000 samples they tested, only one required the longer test to clarify an uncertain result.

Climate change effects on the geographical distribution and incidence of vector - borne diseases in other countries where these diseases are already found can also affect North Americans, especially as a result of increasing trade with, and travel to, tropical and subtropical areas.63, 197 Whether climate change in the U.S. will increase the chances of domestically acquiring diseases such as dengue fever is uncertain, due to vector - control efforts and lifestyle factors, such as time spent indoors, that reduce human - insect contact.

Many aspects of this extreme glaciation remain uncertain, but it is widely thought that the breakup of the supercontinent Rodinia resulted in increased river discharge into the ocean.

Those pollsters who do seek a more thorough understanding of public attitudes find a marked lack of knowledge of the basic facts and even an acknowledgment of that ignorance — resulting in uncertain and highly malleable opinions.

Long - term (decadal and multi-decadal) variation in total annual streamflow is largely influenced by quasi-cyclic changes in sea - surface temperatures and resulting climate conditions; the influence of climate warming on these patterns is uncertain.

Dozens of studies have shown that flowering times for many spring - flowering plants have become earlier as a result of recent climate change, but it is uncertain if flowering times will continue to advance as temperatures rise.

This lack of positive communication allows the voices of those opposed to animal research to dominate public discourse; «alternative facts» become perceived truths with the result that public and political opinion is often uncertain on the use of animals in research.

The study did not compare treadmill walking to different types (or different intensities) of exercise, so it's uncertain whether harder or easier workouts would produce similar results.