Sentences with phrase «uncertain significance»

«We have been extremely conservative in not reporting back variants» of uncertain significance, she said.

However, when specifically asked about a variety of possible incidental findings, only 57 % wanted to know if they were found to have a gene variant that would cause an unpreventable and serious illness, and only 47 % wanted to know about a gene variant of uncertain significance.

Genetic testing labs, including Myriad, normally provide clients with information on gene variants that are known to increase the risk of disease (pathogenic), likely to be pathogenic, or of uncertain significance.

A block of text is titled «Variant of uncertain significance (VUS).»

This is the case at the level of loci (e.g. identifying causal variants underlying genome - wide associations), genes (e.g. understanding not only that mutations in gene X underlie a given phenotype, but also the how and why of it), and variants (e.g. variants of uncertain significance).

In addition, many laboratories do not routinely report variants of uncertain significance (VUS) related to carrier status results.

Researchers have identified disease - causing variants in about a quarter of human genes; many other variants are of uncertain significance.

We are studying the frequency of particular characteristics such as cancer diagnoses among those with PTEN alterations; working to clarify variants of uncertain significance; and exploring alternative mechanisms of disease in patients without identified mutations.

However, in view of the uncertain significance of the difference between the genders, the same protein EAR [i.e., Estimated Average Requirement, a foundation for the RDA] on a body weight basis for both men and women is chosen.

Additonally, the large number of minor characters of uncertain significance may mean some audience members will be left asking their friends to clarify their roles and intentions.