Sentences with phrase «uncertainty changes the environment»

Not at all, but deep uncertainty changes the environment for making robust decisions, relative to optimal decision making.

In the next slide you answer «Not at all, but deep uncertainty changes the environment for making robust decisions, relative to optimal decision making».

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These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Uncertainty around the policy path of President - elect Trump, coupled with a changing interest rate landscape and rising PBGC premiums create a challenging environment for plan sponsors.

It is an indispensable tool profiling the state of the market and how investor demographics, preferences and behaviors have changed in a world economic environment where markets are volatile and uncertainty prevails.

These factors — many of which are beyond our control and the effects of which can be difficult to predict — include: credit, market, liquidity and funding, insurance, operational, regulatory compliance, strategic, reputation, legal and regulatory environment, competitive and systemic risks and other risks discussed in the risk sections of our 2017 Annual Report; including global uncertainty and volatility, elevated Canadian housing prices and household indebtedness, information technology and cyber risk, regulatory change, technological innovation and new entrants, global environmental policy and climate change, changes in consumer behavior, the end of quantitative easing, the business and economic conditions in the geographic regions in which we operate, the effects of changes in government fiscal, monetary and other policies, tax risk and transparency and environmental and social risk.

Meanwhile, uncertainty and change (new governments, a changing economy, potential Euro crises) will modify the players» incentives, priorities and the political environments where they make decisions.

Cooney himself made 294 edits to the administration's 364 - page Strategic Plan for the U.S. Climate Change Science Program posted July 24, 2003, «to exaggerate or emphasize scientific uncertainties or to deemphasize or diminish the importance of the human role in global warming,» and Cooney and the CEQ played a role in eliminating climate change sections in the EPA's draft Report on the Environment as well as its National Air Quality and Emissions Trends RChange Science Program posted July 24, 2003, «to exaggerate or emphasize scientific uncertainties or to deemphasize or diminish the importance of the human role in global warming,» and Cooney and the CEQ played a role in eliminating climate change sections in the EPA's draft Report on the Environment as well as its National Air Quality and Emissions Trends Rchange sections in the EPA's draft Report on the Environment as well as its National Air Quality and Emissions Trends Report.

We could change our current course and try to work carefully with the natural dynamics of the planet and the uncertainties of the environment, especially when it comes to our own inadvertent effects.

The predictability has the potential to make TEL environments ideal for pupils on the autism spectrum who typically experience discomfort at unexpected change and the uncertainty of face - to - face communication.

Actual results may differ materially from those expected because of various known and unknown risks and uncertainties, including, but not limited to, the continuing effects of the U.S. recession and global credit environment, other changes in general economic and industry conditions, the award or loss of significant client assignments, timing of contracts, recruiting and new business solicitation efforts, currency fluctuations, and other factors affecting the financial health of our clients.

Uncertainty around the policy path of President - elect Trump, coupled with a changing interest rate landscape and rising PBGC premiums create a challenging environment for plan sponsors.

Uncertainty and change in the environment affect animals, presenting new stresses and dangers.

Yet, shelter life can be very stressful, and Purrnino is a cat who has been challenged with the constant change and uncertainty of his environment.

Professor Curry has led debate in the science community about the process of reviewing climate change, including giving testimony before the US house subcommittee on environment this year, remarking on the many large uncertainties in forecasting future climate.

In an interview with Yale Environment 360, the Wesleyan University economist talked about why the world needs to start taking steps to adapt to climate change and why strong action must be taken despite uncertainty about the extent of the warming and its ultimate effects.

White House officials and political appointees in the agencies censored congressional testimony on the causes and impacts of global warming, controlled media access to government climate scientists, and edited federal scientific reports to inject unwarranted uncertainty into discussions of climate change and to minimize the threat to the environment and the economy.

Robert Lempert characterizes the decision making environment surrounding climate change as one of deep uncertainty, owing to long time horizons, substantial uncertainty in our understanding of the climate system, and the potential for surprises.

Working in an environment with skin in the game dramatically changed my perspective on uncertainty and confidence.

These perceptions result from the complexities and uncertainties of a changing economic, professional, and competitive environment in which most law firms now find themselves.

The most common challenges that foreign investors and clients face when setting up a business in my country are: qualifying for the complex bidding processes for major projects; finding reliable partners to form partnerships or consortiums; and cultural nuance and legal uncertainty & insecurity caused by changing its regulatory environment and not having legal advisors with the capacity to offer them comprehensive and trustable legal services.

However, the changing regulatory environment brings uncertainties to crypto market.

I seek employment with a company that has a sound business strategy for growing profits in this environment of change and uncertainty, where my skills and competencies can enhance its ability to win in the marketplace.

Parents can help children manage these intense feelings by creating a safe environment for them, and reducing the level of uncertainty around the change.