Sentences with phrase «uncertainty involved for»

Interest rates on personal loans are typically lower than those for personal lines of credit, because there is less uncertainty involved for the lender.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Certain statements in this press release regarding the Company's expected future shipment volumes, gross margins, and its ability to receive the required government approvals for the sale of six solar power projects in California, are forward - looking statements that involve a number of risks and uncertainties that could cause actual results to differ materially.

No one truly knows (legally) what the market is going to do next, and the risk involved in that uncertainty is what creates the potential for significant returns.

Both studies came to the same basic conclusion: that the risks and uncertainties involved in budget forecasting were simply too large to allow for a high level of forecast accuracy.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Successfully managing uncertainty involves neither predicting an outcome and hoping you're right or doing nothing with a «wait and see» attitude; rather, it involves laying the groundwork in advance for all likely eventualities.

There are uncertainties involved, so we included wide - ranging assessments of these, as well as pointers to the most promising avenues for improvement.

This new report, which was written by the International Institute for Strategic Studies (IISS), calls for military and intelligence personnel to have a prominent role in crafting climate policy, since that process involves a complex calculus of weighing uncertainties.

From the examples chosen a pattern emerges that requires a period of sober reflection by any minister or civil servant involved in the planning of major technological projects, for far from the comfort of scientific truth underpinning their decisions, the reality is that the degree of uncertainty involved would appear to reduce the process to a sophisticated form of gambling, with awesome consequences awaiting a wrong decision.

This means that (1) animals are directly involved in an oxygen - regulating cycle or feedback loop that has previously been overlooked, and (2) we can directly test the idea (despite the uncertainties associated with looking so far back in time) by looking for a decrease in ocean oxygenation in conjunction with the spread of bioturbation.

These forward - looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical development of its drug candidates and advance such candidates into clinical development, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as those relating to manufacturing, the regulatory process, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward - looking statements.

These involved calculating weights for the velocity time series from the measurement uncertainties and adjusting them in order to minimize the noise level of the combined data.

We wish to caution readers these statements involve risks and uncertainties that could cause actual results and outcomes for future periods to differ materially from any forward - looking statement or views expressed herein.

therefore is important for them to know the risks and uncertainty that involve decisions regarding investments.

Planning for incentive stock options always involves a level of uncertainty.

Planning for your future naturally involves facing some uncertainty about how the financial markets will perform.

This release contains forward - looking information that involves substantial risks and uncertainties about the intention to file a registration statement with the U.S. Securities and Exchange Commission for an initial public offering of a minority ownership stake in Pfizer's Animal Health business, including the anticipated timing of such a transaction and the potential benefits to Pfizer.

As similar clinics in other areas have done, we offer walk - in appointments for feral cat caregivers because we understand the uncertainties involved with trapping free - roaming cats.

The main reason for this is the degree of uncertainties involved in regional climate modelling, as discussed in a previous post.

All scientific questions involve some degree of uncertainties (error bars), and these can only be reduced if one can prove that they are influenced by an external factor («contamination») or if some of the data are not representative for the study.

There are many uncertainties involved and additional factors which some later theory might account for undoubtedly.

understood perfectly well that there were various degrees of approximation and uncertainty involved, including, for sure, the climate modelers.

I was hoping for a comment on where this paper fits in the scientific consensus, and what kind of uncertainties are involved.

Once this criterion for climate change has been met (and I contend that, at best, it has only barely done so), then we can begin to talk about the further uncertainties involved in attribution.

Scientific predictions of climate change for the next couple centuries, when we already know that CO2 and water vapor will be high, involves much less uncertainty than prediction of climate change when CO2 and water vapor are low.

For example, many projections that include carbon removal solutions involve the large - scale deployment of bioenergy systems, yet critical uncertainties remain around our estimates of:

Accounting for Both Random Errors and Systematic Errors in Uncertainty Propagation Analysis of Computer Models Involving Experimental Measurements with Monte Carlo Methods.

Now, add all those up, with all the uncertainties involved in trying to get a geographic average when, for example, large swaths of the earth are not covered by an official thermometer, and what is the error on the total?

«uncertainty» equals no consensus but consensus is not proof this is just one classic example of just more humans trying to justify their existence and no the IPCC Judith Curry and everyone else involved continue dancing on the head of a pin whilst Mr Ordinary gets his wealth sequestrated in order to pay for these guys to indulge in their pet hobby when the person who is making their life possible derives no benefit whatsoever except higher and higher energy bills, more restrictions on their ability to travel whilst again the lauded few get to travel across the planet 1st class to tout their jaded theories of how what and where and all I hope and pray is that we get another five years of flat temperatures then you are all toast and in a great need of having to work for a living or get another hobby.

I was criticized for my early essays by colleagues because talking about even the broad issues of uncertainty, transparency, losing trust etc was viewed as insensitive to the feelings of the individual scientists involved (and not helping the»cause»).

Equally disturbing and unconscionable is the silence of scientists involved in the IPCC who know the vast difference between the scientific limitations and uncertainties and the certainties produced in the Summary for Policymakers (SPM).

Projections are distinguished from predictions in order to emphasize that projections involve assumptions concerning, for example, future socioeconomic and technological developments that may or may not be realized, and are therefore subject to substantial uncertainty.

Making a direct judgement on uncertainty would in most cases involve me getting a couple of new degrees and working in the given field for years.

Projections are distinguished from predictions in order to emphasize that projections involve assumptions concerning, for example, future socioeconomic and technological developments that may or may not be realised, and are therefore subject to substantial uncertainty.

Initial condition uncertainty arises due to errors in the estimate of the starting conditions for the forecast, both due to limited observations of the atmosphere, and uncertainties involved in using indirect measurements, such as satellite data, to measure the state of atmospheric variables.

Example - Contrarian misuse of uncertainty and temperature sensitivity to argue for no action: A good example involves 1.

In addition to having failed on qualitative and quantitative expressions of uncertainty, being susceptible for noble cause corruption, InterAcademy Council seem to have been heavily involved with United Nations and IPCC — both politically, economically, personally and otherwise.

Subsequent work will involve development of uncertainty estimates for the climatologies and the establishment of regular updates to the monthly maps.

My hope there would simply be not to blur the line between science and policy, backing - off on claims of consensus, using review processes that call for a show of expert's hands and paying more attention to the uncertainties involved in their results and predictions.

As Pekka points out, there is considerable uncertainty associated with the magnitude of projections, but paleoclimatologic data indicate that they are likely to be sufficient to impair the calcification processes essential for the integrity of many marine species involved in the food chain, and thus of concern to us to the extent that our civilization is linked to the welfare of ocean biology...

Yes, there is data analysis involved and there are uncertainties... but if you want to call them «guestimates» for this reason, you'd have to call basically every measurement in the universe a guestimate.

Moreover, using long time periods for averaging makes it impossible to avoid major volcanic eruptions, which involve uncertainty as to the large forcing excursions involved and their effects.

The present paper reviews existing knowledge with regard to Organic Aerosol (OA) of importance for global climate modelling and defines critical gaps needed to reduce the involved uncertainties.

Given the risks and costs involved and the likely changes to contractual provisions required to reflect the position, arguably it would be difficult for contracts to be negotiated fully against a background of uncertainty as to the contractor's amenability to FIA 2000.

For some time all those involved in buying and selling insolvent businesses were faced with uncertainty when one division of the Employment Appeal Tribunal (EAT) suggested that intention had to be judged case by case, depending on the facts.

Implementing regulation also removes uncertainty for investors as well as the companies who are involved in ICO's.

The opening of insolvency or debt - restructuring proceedings can lead to considerable uncertainties for the parties involved.

If you have been involved in a car accident in Bakersfield, you are likely experiencing uncertainty about how to recover compensation for your losses.

The series examines the legal uncertainties facing landlords and property managers seeking to respond to domestic violence involving their tenants, as identified in the Centre for Public Legal Education Alberta (CPLEA) report on Domestic Violence: Roles of Landlords and Property Managers.